ISM2 (isthmin 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 145501
• Gene name: Isthmin 2
• Gene symbol: ISM2
• Synonyms (NCBI Gene): TAIL1, THSD3
• Chromosome: 14
• Chromosome location: 14q24.3
• Summary: The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript varian

miRNA Show/Hide all (50)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049167	hsa-miR-92a-3p	CLASH	23622248
MIRT042370	hsa-miR-484	CLASH	23622248
MIRT1072762	hsa-miR-103a	CLIP-seq
MIRT1072763	hsa-miR-107	CLIP-seq
MIRT1072764	hsa-miR-1207-3p	CLIP-seq
MIRT1072765	hsa-miR-1281	CLIP-seq
MIRT1072766	hsa-miR-1302	CLIP-seq
MIRT1072767	hsa-miR-150	CLIP-seq
MIRT1072768	hsa-miR-1587	CLIP-seq
MIRT1072769	hsa-miR-2467-3p	CLIP-seq
MIRT1072770	hsa-miR-298	CLIP-seq
MIRT1072771	hsa-miR-3127-5p	CLIP-seq
MIRT1072772	hsa-miR-3141	CLIP-seq
MIRT1072773	hsa-miR-3150b-3p	CLIP-seq
MIRT1072774	hsa-miR-3173-3p	CLIP-seq
MIRT1072775	hsa-miR-3662	CLIP-seq
MIRT1072776	hsa-miR-3678-3p	CLIP-seq
MIRT1072777	hsa-miR-378g	CLIP-seq
MIRT1072778	hsa-miR-3918	CLIP-seq
MIRT1072779	hsa-miR-4267	CLIP-seq
MIRT1072780	hsa-miR-4298	CLIP-seq
MIRT1072781	hsa-miR-4327	CLIP-seq
MIRT1072782	hsa-miR-4436b-3p	CLIP-seq
MIRT1072783	hsa-miR-4488	CLIP-seq
MIRT1072784	hsa-miR-4489	CLIP-seq
MIRT1072785	hsa-miR-4492	CLIP-seq
MIRT1072786	hsa-miR-4498	CLIP-seq
MIRT1072787	hsa-miR-4529-5p	CLIP-seq
MIRT1072788	hsa-miR-4656	CLIP-seq
MIRT1072789	hsa-miR-4667-5p	CLIP-seq
MIRT1072790	hsa-miR-4675	CLIP-seq
MIRT1072791	hsa-miR-4685-5p	CLIP-seq
MIRT1072792	hsa-miR-4697-5p	CLIP-seq
MIRT1072793	hsa-miR-4700-5p	CLIP-seq
MIRT1072794	hsa-miR-4741	CLIP-seq
MIRT1072795	hsa-miR-4784	CLIP-seq
MIRT1072796	hsa-miR-637	CLIP-seq
MIRT1072797	hsa-miR-762	CLIP-seq
MIRT1072798	hsa-miR-765	CLIP-seq
MIRT1072799	hsa-miR-885-3p	CLIP-seq
MIRT2553261	hsa-miR-3117-3p	CLIP-seq
MIRT2553262	hsa-miR-3169	CLIP-seq
MIRT1072784	hsa-miR-4489	CLIP-seq
MIRT2553263	hsa-miR-4740-5p	CLIP-seq
MIRT2553264	hsa-miR-4759	CLIP-seq
MIRT2553261	hsa-miR-3117-3p	CLIP-seq
MIRT2553262	hsa-miR-3169	CLIP-seq
MIRT1072784	hsa-miR-4489	CLIP-seq
MIRT2553263	hsa-miR-4740-5p	CLIP-seq
MIRT2553264	hsa-miR-4759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA

Other IDs

• MIM: 612684
• HGNC: 23176
• e!Ensembl: ENSG00000100593

Protein

• UniProt ID: Q6H9L7
• Protein name: Isthmin-2 (Thrombospondin and AMOP domain-containing isthmin-like protein 1) (Thrombospondin type-1 domain-containing protein 3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03782	AMOP	400 → 563	AMOP domain	Domain
  PF00090	TSP_1	330 → 370	Thrombospondin type 1 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at high levels in the placenta and at moderate levels in the pancreas, kidney, heart, liver, lung, brain and skeletal muscle. {ECO:0000269|PubMed:15194193}.
• Sequence:

  MRALRDRAGLLLCVLLLAALLEAALGLPVKKPRLRGPRPGSLTRLAEVSASPDPRPLKEE
  EEAPLLPRTHLQAEPHQHGCWTVTEPAAMTPGNATPPRTPEVTPLRLELQKLPGLANTTL
  STPNPDTQASASPDPRPLREEEEARLLPRTHLQAELHQHGCWTVTEPAALTPGNATPPRT
  QEVTPLLLELQKLPELVHATLSTPNPDNQVTIKVVEDPQAEVSIDLLAEPSNPPPQDTLS
  WLPALWSFLWGDYKGEEKDRAPGEKGEEKEEDEDYPSEDIEGEDQEDKEEDEEEQALWFN
  GTTDNWDQGWLAPGDWVFKDSVSYDYEPQKEWSPWSPCSGNCSTGKQQRTRPCGYGCTAT
  ETRTCDLPSCPGTEDKDTLGLPSEEWKLLARNATDMHDQDVDSCEKWLNCKSDFLIKYLS
  QMLRDLPSCPCAYPLEAMDSPVSLQDEHQGRSFRWRDASGPRERLDIYQPTARFCLRSML
  SGESSTLAAQHCCYDEDSRLLTRGKGAGMPNLISTDFSPKLHFKFDTTPWILCKGDWSRL
  HAVLPPNNGRACTDNPLEEEYLAQLQEAKEY

• Sequence length: 571

Related Genes

No strongly related genes found yet for ISM2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ISM2.