ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57611
• Gene name: Immunoglobulin superfamily containing leucine rich repeat 2
• Gene symbol: ISLR2
• Synonyms (NCBI Gene): LINX
• Chromosome: 15
• Chromosome location: 15q24.1

miRNA Show/Hide all (104)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039768	hsa-miR-615-3p	CLASH	23622248
MIRT571101	hsa-miR-6815-5p	PAR-CLIP	20371350
MIRT571099	hsa-miR-6865-5p	PAR-CLIP	20371350
MIRT571098	hsa-miR-3689d	PAR-CLIP	20371350
MIRT571097	hsa-miR-6851-5p	PAR-CLIP	20371350
MIRT571095	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT571096	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT571094	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT571093	hsa-miR-6802-5p	PAR-CLIP	20371350
MIRT571092	hsa-miR-425-3p	PAR-CLIP	20371350
MIRT528995	hsa-miR-4282	PAR-CLIP	21572407
MIRT528994	hsa-miR-5692a	PAR-CLIP	21572407
MIRT528993	hsa-miR-3163	PAR-CLIP	21572407
MIRT528992	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT528995	hsa-miR-4282	PAR-CLIP	22012620
MIRT528994	hsa-miR-5692a	PAR-CLIP	22012620
MIRT528993	hsa-miR-3163	PAR-CLIP	22012620
MIRT528992	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT528991	hsa-miR-8485	PAR-CLIP	22012620
MIRT528990	hsa-miR-603	PAR-CLIP	22012620
MIRT528989	hsa-miR-4640-3p	PAR-CLIP	22012620
MIRT528988	hsa-miR-3162-3p	PAR-CLIP	22012620
MIRT528987	hsa-miR-6798-3p	PAR-CLIP	22012620
MIRT571101	hsa-miR-6815-5p	PAR-CLIP	20371350
MIRT571099	hsa-miR-6865-5p	PAR-CLIP	20371350
MIRT571098	hsa-miR-3689d	PAR-CLIP	20371350
MIRT571097	hsa-miR-6851-5p	PAR-CLIP	20371350
MIRT571095	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT571096	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT571094	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT571093	hsa-miR-6802-5p	PAR-CLIP	20371350
MIRT571092	hsa-miR-425-3p	PAR-CLIP	20371350
MIRT528995	hsa-miR-4282	PAR-CLIP	21572407
MIRT528994	hsa-miR-5692a	PAR-CLIP	21572407
MIRT528993	hsa-miR-3163	PAR-CLIP	21572407
MIRT528992	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT528995	hsa-miR-4282	PAR-CLIP	22012620
MIRT528994	hsa-miR-5692a	PAR-CLIP	22012620
MIRT528993	hsa-miR-3163	PAR-CLIP	22012620
MIRT528992	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT528991	hsa-miR-8485	PAR-CLIP	22012620
MIRT528990	hsa-miR-603	PAR-CLIP	22012620
MIRT528989	hsa-miR-4640-3p	PAR-CLIP	22012620
MIRT528988	hsa-miR-3162-3p	PAR-CLIP	22012620
MIRT528987	hsa-miR-6798-3p	PAR-CLIP	22012620
MIRT1072731	hsa-miR-2110	CLIP-seq
MIRT1072732	hsa-miR-3126-5p	CLIP-seq
MIRT1072733	hsa-miR-3127-3p	CLIP-seq
MIRT1072734	hsa-miR-3132	CLIP-seq
MIRT1072735	hsa-miR-3150a-3p	CLIP-seq
MIRT1072736	hsa-miR-3175	CLIP-seq
MIRT1072737	hsa-miR-3179	CLIP-seq
MIRT1072738	hsa-miR-3202	CLIP-seq
MIRT1072739	hsa-miR-3649	CLIP-seq
MIRT1072740	hsa-miR-376c	CLIP-seq
MIRT1072741	hsa-miR-4446-5p	CLIP-seq
MIRT1072742	hsa-miR-4505	CLIP-seq
MIRT1072743	hsa-miR-4646-5p	CLIP-seq
MIRT1072744	hsa-miR-4648	CLIP-seq
MIRT1072745	hsa-miR-4681	CLIP-seq
MIRT1072746	hsa-miR-4690-5p	CLIP-seq
MIRT1072747	hsa-miR-4704-3p	CLIP-seq
MIRT1072748	hsa-miR-4747-5p	CLIP-seq
MIRT1072749	hsa-miR-4749-3p	CLIP-seq
MIRT1072750	hsa-miR-4761-5p	CLIP-seq
MIRT1072751	hsa-miR-4802-5p	CLIP-seq
MIRT1072752	hsa-miR-485-5p	CLIP-seq
MIRT1072753	hsa-miR-609	CLIP-seq
MIRT1072754	hsa-miR-885-3p	CLIP-seq
MIRT1072755	hsa-miR-939	CLIP-seq
MIRT1550227	hsa-miR-4717-5p	CLIP-seq
MIRT2249707	hsa-miR-3134	CLIP-seq
MIRT2249708	hsa-miR-570	CLIP-seq
MIRT2553181	hsa-miR-1273	CLIP-seq
MIRT2553182	hsa-miR-141	CLIP-seq
MIRT2553183	hsa-miR-1827	CLIP-seq
MIRT2553184	hsa-miR-1908	CLIP-seq
MIRT2553185	hsa-miR-200a	CLIP-seq
MIRT2553186	hsa-miR-218	CLIP-seq
MIRT2553187	hsa-miR-3121-3p	CLIP-seq
MIRT2553188	hsa-miR-4252	CLIP-seq
MIRT2553189	hsa-miR-4271	CLIP-seq
MIRT2553190	hsa-miR-4432	CLIP-seq
MIRT2553191	hsa-miR-4684-5p	CLIP-seq
MIRT2553192	hsa-miR-4706	CLIP-seq
MIRT2553193	hsa-miR-4725-3p	CLIP-seq
MIRT2553194	hsa-miR-4730	CLIP-seq
MIRT1072748	hsa-miR-4747-5p	CLIP-seq
MIRT2553195	hsa-miR-4749-5p	CLIP-seq
MIRT2553196	hsa-miR-4793-3p	CLIP-seq
MIRT2553197	hsa-miR-508-5p	CLIP-seq
MIRT2553198	hsa-miR-548c-3p	CLIP-seq
MIRT2553199	hsa-miR-636	CLIP-seq
MIRT2553200	hsa-miR-663	CLIP-seq
MIRT2553201	hsa-miR-766	CLIP-seq
MIRT2553181	hsa-miR-1273	CLIP-seq
MIRT2553183	hsa-miR-1827	CLIP-seq
MIRT2553187	hsa-miR-3121-3p	CLIP-seq
MIRT2553188	hsa-miR-4252	CLIP-seq
MIRT2553191	hsa-miR-4684-5p	CLIP-seq
MIRT2553196	hsa-miR-4793-3p	CLIP-seq
MIRT2553197	hsa-miR-508-5p	CLIP-seq
MIRT2553198	hsa-miR-548c-3p	CLIP-seq
MIRT2553201	hsa-miR-766	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	ISS
GO:0016020	Component	Membrane	IEA
GO:0045773	Process	Positive regulation of axon extension	IBA
GO:0045773	Process	Positive regulation of axon extension	ISS

Other IDs

• MIM: 614179
• HGNC: 29286
• e!Ensembl: ENSG00000167178

Protein

• UniProt ID: Q6UXK2
• Protein name: Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein)
• Protein function: Required for axon extension during neural development.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	51 → 111	Leucine rich repeat	Repeat
  PF13855	LRR_8	123 → 183	Leucine rich repeat	Repeat
  PF13855	LRR_8	76 → 135	Leucine rich repeat	Repeat

• Sequence:

  MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSA
  NKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLR
  NLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYH
  NPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAE
  PPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEG
  EGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNE
  LGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQ
  GLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELK
  PHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAA
  VQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFL
  LVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPA
  GGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYS
  DRLPLGAEAVNIAQEINGNYRQTAG

• Sequence length: 745

Related Genes

No strongly related genes found yet for ISLR2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ISLR2.