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Gene Gene information from NCBI Gene database.
Entrez ID 81875
Gene name Interferon stimulated exonuclease gene 20 like 2
Gene symbol ISG20L2
Synonyms (NCBI Gene)
HSD38
Chromosome 1
Chromosome location 1q23.1
Summary This gene encodes a 3`-5` exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]
miRNA miRNA information provided by mirtarbase database.
524 Show/Hide all (524)
miRTarBase ID miRNA Experiments Reference
MIRT046613 hsa-miR-222-3p CLASH 23622248
MIRT036818 hsa-miR-877-3p CLASH 23622248
MIRT687838 hsa-miR-562 HITS-CLIP 23313552
MIRT687837 hsa-miR-552-3p HITS-CLIP 23313552
MIRT687836 hsa-miR-5697 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-RNA exonuclease activity IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0004518 Function Nuclease activity IEA
GO:0004527 Function Exonuclease activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611930 25745 ENSG00000143319
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H9L3
Protein name Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-)
Protein function 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.
PDB 7YW5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00929 RNase_T 180 → 335 Exonuclease Family
Sequence
MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPSK
KGETPTVDGTWKTPSFPKKKTAASSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLG
EFQSALPKINSHPTRSQKKSSQKKSSKKNHPQKNAPQNSTQAHSENKCSGASQKLPRKMV
AIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNA
TPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENAT
MSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELY
KLVEVEWEEHLARNPPTD
Sequence length 353
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Major pathway of rRNA processing in the nucleolus and cytosol