INSM2 (INSM transcriptional repressor 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84684
• Gene name: INSM transcriptional repressor 2
• Gene symbol: INSM2
• Synonyms (NCBI Gene): IA-6, IA6, mlt1
• Chromosome: 14
• Chromosome location: 14q13.2

miRNA Show/Hide all (25)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018669	hsa-miR-335-5p	Microarray	18185580
MIRT1067769	hsa-miR-1200	CLIP-seq
MIRT1067770	hsa-miR-1236	CLIP-seq
MIRT1067771	hsa-miR-200b	CLIP-seq
MIRT1067772	hsa-miR-200c	CLIP-seq
MIRT1067773	hsa-miR-3140-5p	CLIP-seq
MIRT1067774	hsa-miR-3616-5p	CLIP-seq
MIRT1067775	hsa-miR-3647-5p	CLIP-seq
MIRT1067776	hsa-miR-429	CLIP-seq
MIRT1067777	hsa-miR-4427	CLIP-seq
MIRT1067778	hsa-miR-4635	CLIP-seq
MIRT1067779	hsa-miR-514	CLIP-seq
MIRT1067780	hsa-miR-514b-3p	CLIP-seq
MIRT1067781	hsa-miR-562	CLIP-seq
MIRT1067782	hsa-miR-573	CLIP-seq
MIRT1556576	hsa-miR-186	CLIP-seq
MIRT1556577	hsa-miR-3133	CLIP-seq
MIRT1556578	hsa-miR-3686	CLIP-seq
MIRT1556579	hsa-miR-4742-3p	CLIP-seq
MIRT2016438	hsa-miR-1208	CLIP-seq
MIRT2016439	hsa-miR-144	CLIP-seq
MIRT2016440	hsa-miR-425	CLIP-seq
MIRT2016441	hsa-miR-4420	CLIP-seq
MIRT2248688	hsa-miR-1224-3p	CLIP-seq
MIRT2248689	hsa-miR-3591-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010564	Process	Regulation of cell cycle process	IBA
GO:0017053	Component	Transcription repressor complex	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030182	Process	Neuron differentiation	IBA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 614027
• HGNC: 17539
• e!Ensembl: ENSG00000168348

Protein

• UniProt ID: Q96T92
• Protein name: Insulinoma-associated protein 2 (Zinc finger protein IA-6)
• Protein function: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	426 → 448	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	291 → 313	Zinc finger, C2H2 type	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in
• Sequence:

  MPRGFLVKRTKRTGGLYRVRLAERVFPLLGPQGAPPFLEEAPSASLPGAERATPPTREEP
  GKGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGREGPGPSPSPSPSPAKPAGAEL
  RRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPGEQFLLPLRAPFPEPALQPD
  PAPLSAALQSLKRAAGGERRGKAPTDCASGPAAAGIKKPKAMRKLSFADEVTTSPVLGLK
  IKEEEPGAPSRGLGGSRTPLGEFICQLCKEQYADPFALAQHRCSRIVRVEYRCPECDKVF
  SCPANLASHRRWHKPRPAAANAATVSSADGKPPSSSSSSSRDSGAIASFLAEGKENSRIE
  RTADQHPQARDSSGADQHPDSAPRQGLQVLTHPEPPLPQGPYTEGVLGRRVPVPGSTSGG
  RGSEIFVCPYCHKKFRRQAYLRKHLSTHEAGSARALAPGFGSERGAPLAFACPLCGAHFP
  TADIREKHRLWHAVREELLLPALAGAPPETSGPSGPSDGSAQQIFSCKHCPSTFFSSPGL
  TRHINKCHPSESRQVLLLQMPLRPGC

• Sequence length: 566

Related Genes

No strongly related genes found yet for INSM2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to INSM2.