IGSF8 (immunoglobulin superfamily member 8)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 93185
• Gene name: Immunoglobulin superfamily member 8
• Gene symbol: IGSF8
• Synonyms (NCBI Gene): CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL
• Chromosome: 1
• Chromosome location: 1q23.2
• Summary: This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with t

miRNA Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025764	hsa-miR-7-5p	Microarray	17612493
MIRT051892	hsa-let-7b-5p	CLASH	23622248
MIRT040653	hsa-miR-92b-3p	CLASH	23622248
MIRT037601	hsa-miR-744-5p	CLASH	23622248
MIRT025764	hsa-miR-7-5p	PAR-CLIP	27292025
MIRT1062810	hsa-miR-3129-3p	CLIP-seq
MIRT1062811	hsa-miR-4436a	CLIP-seq
MIRT1062812	hsa-miR-4757-5p	CLIP-seq
MIRT1062813	hsa-miR-548ae	CLIP-seq
MIRT1062814	hsa-miR-548aj	CLIP-seq
MIRT1062815	hsa-miR-548am	CLIP-seq
MIRT1062816	hsa-miR-548x	CLIP-seq
MIRT1062817	hsa-miR-665	CLIP-seq
MIRT2247117	hsa-miR-1321	CLIP-seq
MIRT2247118	hsa-miR-2110	CLIP-seq
MIRT2247119	hsa-miR-2276	CLIP-seq
MIRT2247120	hsa-miR-3179	CLIP-seq
MIRT2247121	hsa-miR-3184	CLIP-seq
MIRT2247122	hsa-miR-3202	CLIP-seq
MIRT2247123	hsa-miR-3612	CLIP-seq
MIRT2247124	hsa-miR-3622a-5p	CLIP-seq
MIRT2247125	hsa-miR-3661	CLIP-seq
MIRT2247126	hsa-miR-423-5p	CLIP-seq
MIRT2247127	hsa-miR-4271	CLIP-seq
MIRT2247128	hsa-miR-4481	CLIP-seq
MIRT2247129	hsa-miR-4533	CLIP-seq
MIRT2247130	hsa-miR-4696	CLIP-seq
MIRT2247131	hsa-miR-4725-3p	CLIP-seq
MIRT2247132	hsa-miR-4739	CLIP-seq
MIRT2247133	hsa-miR-4745-5p	CLIP-seq
MIRT2247134	hsa-miR-4747-5p	CLIP-seq
MIRT2247135	hsa-miR-4756-5p	CLIP-seq
MIRT2247136	hsa-miR-491-5p	CLIP-seq
MIRT2247137	hsa-miR-631	CLIP-seq
MIRT2247138	hsa-miR-650	CLIP-seq
MIRT2550623	hsa-miR-150	CLIP-seq
MIRT2550624	hsa-miR-4314	CLIP-seq
MIRT2550625	hsa-miR-4713-5p	CLIP-seq
MIRT2550626	hsa-miR-532-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11504738, 25416956, 32296183
GO:0005886	Component	Plasma membrane	IC	17785435
GO:0005886	Component	Plasma membrane	IEA
GO:0007338	Process	Single fertilization	NAS	11504738
GO:0007399	Process	Nervous system development	NAS	11504738
GO:0007519	Process	Skeletal muscle tissue development	NAS	11504738
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	11504738
GO:0016020	Component	Membrane	IEA
GO:0030335	Process	Positive regulation of cell migration	IDA	17785435
GO:0038023	Function	Signaling receptor activity	IDA	17785435
GO:0042734	Component	Presynaptic membrane	IEA
GO:0048870	Process	Cell motility	NAS	11504738
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:2000145	Process	Regulation of cell motility	IEA

Other IDs

• MIM: 606644
• HGNC: 17813
• e!Ensembl: ENSG00000162729

Protein

• UniProt ID: Q969P0
• Protein name: Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
• Protein function: Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, PubMed:14662754). Acts as an inducible rec
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	33 → 149	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells (PubMed:12708969). Expressed on dendritic cells (PubMed:17785435
• Sequence:

  MGALRPTLLPPSLPLLLLLMLGMGCWAREVLVPEGPLYRVAGTAVSISCNVTGYEGPAQQ
  NFEWFLYRPEAPDTALGIVSTKDTQFSYAVFKSRVVAGEVQVQRLQGDAVVLKIARLQAQ
  DAGIYECHTPSTDTRYLGSYSGKVELRVLPDVLQVSAAPPGPRGRQAPTSPPRMTVHEGQ
  ELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAERLAA
  GELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQT
  LSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVA
  QLDTEGVGSLGPGYEGRHIAMEKVASRTYRLRLEAARPGDAGTYRCLAKAYVRGSGTRLR
  EAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAASWW
  VERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEG
  VYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYMHALDTLFVPLLVGTGVALVTGATVLG
  TITCCFMKRLRKR

• Sequence length: 613

Related Genes

No strongly related genes found yet for IGSF8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to IGSF8.