IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 3500
• Gene name: Immunoglobulin heavy constant gamma 1 (G1m marker)
• Gene symbol: IGHG1
• Synonyms (NCBI Gene): -
• Chromosome: 14
• Chromosome location: 14q32.33

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001788	Process	Antibody-dependent cellular cytotoxicity	IDA	11711607
GO:0002250	Process	Adaptive immune response	IDA	11498595
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	NAS	20176268
GO:0002376	Process	Immune system process	IEA
GO:0003823	Function	Antigen binding	IBA
GO:0003823	Function	Antigen binding	TAS	6287432
GO:0005515	Function	Protein binding	IPI	11567028, 16646632, 25925696
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 23580065
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005615	Component	Extracellular space	NAS	20176268
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	20176268
GO:0006958	Process	Complement activation, classical pathway	IBA
GO:0016020	Component	Membrane	IEA
GO:0019731	Process	Antibacterial humoral response	IBA
GO:0019814	Component	Immunoglobulin complex	IEA
GO:0034987	Function	Immunoglobulin receptor binding	IBA
GO:0034988	Function	Fc-gamma receptor I complex binding	IDA	11711607
GO:0042571	Component	Immunoglobulin complex, circulating	IBA
GO:0050853	Process	B cell receptor signaling pathway	NAS	20176268
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071735	Component	IgG immunoglobulin complex	IPI	11498595, 22839360
GO:0071735	Component	IgG immunoglobulin complex	ISS
GO:0071735	Component	IgG immunoglobulin complex	NAS	20176268
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0097278	Process	Complement-dependent cytotoxicity	IDA	11711607

Other IDs

• MIM: 147100
• HGNC: 5525
• e!Ensembl: ENSG00000211896

Protein

• UniProt ID: P01857
• Protein name: Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
• Protein function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins s
• PDB: 1AJ7 , 1AQK , 1AXS , 1BEY , 1D5B , 1D5I , 1D6V , 1DFB , 1DN2 , 1E4K , 1FC1 , 1FC2 , 1FCC , 1GAF , 1H3T , 1H3U , 1H3V , 1H3W , 1H3X , 1H3Y , 1HKL , 1HZH , 1I7Z , 1L6X , 1N7M , 1OQO , 1OQX , 1PG7 , 1T83 , 1T89 , 1VGE , 2DTS , 2GJ7 , 2I5Y , 2IWG , 2J6E , 2JB5 , 2JB6 , 2O5X , 2O5Y , 2O5Z , 2OSL , 2QAD , 2QL1 , 2QQK , 2QQL , 2QQN , 2QR0 , 2R56 , 2RCS , 2VXQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07654	C1-set	231 → 315	Immunoglobulin C1-set domain	Domain
  PF07654	C1-set	123 → 211	Immunoglobulin C1-set domain	Domain
  PF07654	C1-set	8 → 90	Immunoglobulin C1-set domain	Domain

• Sequence:

  ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS
  GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGG
  PSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYN
  STYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE
  LTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRW
  QQGNVFSCSVMHEALHNHYTQKSLSLSPGK

• Sequence length: 330

Related Genes

No strongly related genes found yet for IGHG1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to IGHG1.