IGFBPL1 (insulin like growth factor binding protein like 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 347252 |
| Gene name | Insulin like growth factor binding protein like 1 |
| Gene symbol | IGFBPL1 |
| Synonyms (NCBI Gene) |
IGFBP-RP4IGFBPRP4bA113O24.1
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| Chromosome | 9 |
| Chromosome location | 9p13.1 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8WX77 | ||||||||||||||||||||
| Protein name | Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4) | ||||||||||||||||||||
| Protein function | IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). | ||||||||||||||||||||
| PDB | 7MJ6 , 7MJ7 , 7MJ8 , 7MJ9 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. {ECO:0000269|PubMed:15845387}. | ||||||||||||||||||||
| Sequence |
MPRLSLLLPLLLLLLLPLLPPLSPSLGIRDVGGRRPKCGPCRPEGCPAPAPCPAPGISAL |
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| Sequence length | 278 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with IGFBPL1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to IGFBPL1 (see Related Genes above), that are NOT already directly curated for IGFBPL1 itself -- a lead worth checking, not a confirmed association.
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