IFRD2 (interferon related developmental regulator 2)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7866
• Gene name: Interferon related developmental regulator 2
• Gene symbol: IFRD2
• Synonyms (NCBI Gene): IFNRP, SKMc15, SM15
• Chromosome: 3
• Chromosome location: 3p21.31

miRNA Show/Hide all (136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001452	hsa-miR-16-5p	pSILAC	18668040
MIRT002649	hsa-miR-124-3p	Microarray	15685193
MIRT002649	hsa-miR-124-3p	Microarray	18668037
MIRT028528	hsa-miR-30a-5p	Proteomics	18668040
MIRT029521	hsa-miR-26b-5p	Microarray	19088304
MIRT001452	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT039999	hsa-miR-615-3p	CLASH	23622248
MIRT002649	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT563118	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT563117	hsa-miR-6779-3p	PAR-CLIP	20371350
MIRT563116	hsa-miR-4293	PAR-CLIP	20371350
MIRT563115	hsa-miR-596	PAR-CLIP	20371350
MIRT563114	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT563113	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT563112	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT563111	hsa-miR-4319	PAR-CLIP	20371350
MIRT563110	hsa-miR-544b	PAR-CLIP	20371350
MIRT563109	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT563108	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT563107	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT563106	hsa-miR-4758-3p	PAR-CLIP	20371350
MIRT563105	hsa-miR-3189-5p	PAR-CLIP	20371350
MIRT563104	hsa-miR-7976	PAR-CLIP	20371350
MIRT563103	hsa-miR-3915	PAR-CLIP	20371350
MIRT002649	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT563118	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT563117	hsa-miR-6779-3p	PAR-CLIP	20371350
MIRT563116	hsa-miR-4293	PAR-CLIP	20371350
MIRT563115	hsa-miR-596	PAR-CLIP	20371350
MIRT563114	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT563113	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT563112	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT563111	hsa-miR-4319	PAR-CLIP	20371350
MIRT563110	hsa-miR-544b	PAR-CLIP	20371350
MIRT563109	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT563108	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT563107	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT563106	hsa-miR-4758-3p	PAR-CLIP	20371350
MIRT563105	hsa-miR-3189-5p	PAR-CLIP	20371350
MIRT563104	hsa-miR-7976	PAR-CLIP	20371350
MIRT563103	hsa-miR-3915	PAR-CLIP	20371350
MIRT1060960	hsa-miR-106a	CLIP-seq
MIRT1060961	hsa-miR-106b	CLIP-seq
MIRT1060962	hsa-miR-124	CLIP-seq
MIRT1060963	hsa-miR-125b	CLIP-seq
MIRT1060964	hsa-miR-142-5p	CLIP-seq
MIRT1060965	hsa-miR-17	CLIP-seq
MIRT1060966	hsa-miR-200b	CLIP-seq
MIRT1060967	hsa-miR-200c	CLIP-seq
MIRT1060968	hsa-miR-20a	CLIP-seq
MIRT1060969	hsa-miR-20b	CLIP-seq
MIRT1060970	hsa-miR-3165	CLIP-seq
MIRT1060971	hsa-miR-3182	CLIP-seq
MIRT1060972	hsa-miR-3202	CLIP-seq
MIRT1060973	hsa-miR-3609	CLIP-seq
MIRT1060974	hsa-miR-3922-5p	CLIP-seq
MIRT1060975	hsa-miR-3928	CLIP-seq
MIRT1060976	hsa-miR-3945	CLIP-seq
MIRT1060977	hsa-miR-4251	CLIP-seq
MIRT1060978	hsa-miR-429	CLIP-seq
MIRT1060979	hsa-miR-4324	CLIP-seq
MIRT1060980	hsa-miR-4456	CLIP-seq
MIRT1060981	hsa-miR-4476	CLIP-seq
MIRT1060982	hsa-miR-4504	CLIP-seq
MIRT1060983	hsa-miR-4652-3p	CLIP-seq
MIRT1060984	hsa-miR-4708-3p	CLIP-seq
MIRT1060985	hsa-miR-4761-3p	CLIP-seq
MIRT1060986	hsa-miR-4788	CLIP-seq
MIRT1060987	hsa-miR-4796-3p	CLIP-seq
MIRT1060988	hsa-miR-506	CLIP-seq
MIRT1060989	hsa-miR-519d	CLIP-seq
MIRT1060990	hsa-miR-539	CLIP-seq
MIRT1060991	hsa-miR-548ah	CLIP-seq
MIRT1060992	hsa-miR-548c-3p	CLIP-seq
MIRT1060993	hsa-miR-616	CLIP-seq
MIRT1060994	hsa-miR-659	CLIP-seq
MIRT1060995	hsa-miR-93	CLIP-seq
MIRT2014239	hsa-miR-3065-3p	CLIP-seq
MIRT1060981	hsa-miR-4476	CLIP-seq
MIRT2014240	hsa-miR-4719	CLIP-seq
MIRT2014241	hsa-miR-500a	CLIP-seq
MIRT1060992	hsa-miR-548c-3p	CLIP-seq
MIRT2246453	hsa-miR-198	CLIP-seq
MIRT2246454	hsa-miR-296-5p	CLIP-seq
MIRT2246455	hsa-miR-361-3p	CLIP-seq
MIRT2246456	hsa-miR-4669	CLIP-seq
MIRT2014240	hsa-miR-4719	CLIP-seq
MIRT2246457	hsa-miR-654-3p	CLIP-seq
MIRT1060962	hsa-miR-124	CLIP-seq
MIRT1060963	hsa-miR-125b	CLIP-seq
MIRT2549951	hsa-miR-1909	CLIP-seq
MIRT1060966	hsa-miR-200b	CLIP-seq
MIRT1060967	hsa-miR-200c	CLIP-seq
MIRT2246454	hsa-miR-296-5p	CLIP-seq
MIRT1060970	hsa-miR-3165	CLIP-seq
MIRT2549952	hsa-miR-3176	CLIP-seq
MIRT2549953	hsa-miR-3179	CLIP-seq
MIRT1060972	hsa-miR-3202	CLIP-seq
MIRT2246455	hsa-miR-361-3p	CLIP-seq
MIRT2549954	hsa-miR-3922-3p	CLIP-seq
MIRT1060975	hsa-miR-3928	CLIP-seq
MIRT2549955	hsa-miR-3936	CLIP-seq
MIRT1060978	hsa-miR-429	CLIP-seq
MIRT1060979	hsa-miR-4324	CLIP-seq
MIRT2549956	hsa-miR-4325	CLIP-seq
MIRT2549957	hsa-miR-4329	CLIP-seq
MIRT2549958	hsa-miR-4436a	CLIP-seq
MIRT2549959	hsa-miR-4446-3p	CLIP-seq
MIRT1060980	hsa-miR-4456	CLIP-seq
MIRT1060981	hsa-miR-4476	CLIP-seq
MIRT2549960	hsa-miR-4656	CLIP-seq
MIRT2246456	hsa-miR-4669	CLIP-seq
MIRT2549961	hsa-miR-4684-3p	CLIP-seq
MIRT2549962	hsa-miR-4700-3p	CLIP-seq
MIRT2549963	hsa-miR-4786-5p	CLIP-seq
MIRT1060988	hsa-miR-506	CLIP-seq
MIRT1060962	hsa-miR-124	CLIP-seq
MIRT1060963	hsa-miR-125b	CLIP-seq
MIRT2549951	hsa-miR-1909	CLIP-seq
MIRT2246454	hsa-miR-296-5p	CLIP-seq
MIRT2549952	hsa-miR-3176	CLIP-seq
MIRT2549953	hsa-miR-3179	CLIP-seq
MIRT1060972	hsa-miR-3202	CLIP-seq
MIRT2246455	hsa-miR-361-3p	CLIP-seq
MIRT2549954	hsa-miR-3922-3p	CLIP-seq
MIRT1060975	hsa-miR-3928	CLIP-seq
MIRT2549955	hsa-miR-3936	CLIP-seq
MIRT1060979	hsa-miR-4324	CLIP-seq
MIRT2549957	hsa-miR-4329	CLIP-seq
MIRT2549958	hsa-miR-4436a	CLIP-seq
MIRT2549959	hsa-miR-4446-3p	CLIP-seq
MIRT1060981	hsa-miR-4476	CLIP-seq
MIRT2549960	hsa-miR-4656	CLIP-seq
MIRT2246456	hsa-miR-4669	CLIP-seq
MIRT2549962	hsa-miR-4700-3p	CLIP-seq
MIRT1060988	hsa-miR-506	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21903422, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0006417	Process	Regulation of translation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0017148	Process	Negative regulation of translation	IDA	30355441
GO:0030371	Function	Translation repressor activity	IDA	30355441
GO:0030371	Function	Translation repressor activity	IEA
GO:0043022	Function	Ribosome binding	IDA	30355441
GO:0043022	Function	Ribosome binding	IEA
GO:0045444	Process	Fat cell differentiation	IEA
GO:0060612	Process	Adipose tissue development	IEA

Other IDs

• MIM: 602725
• HGNC: 5457
• e!Ensembl: ENSG00000214706

Protein

• UniProt ID: Q12894
• Protein name: Interferon-related developmental regulator 2 (Protein SKMC15)
• Protein function: Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (PubMed:30355441). Associates with the P- and E-sites of the ribosome and inserts a C-terminal helix into the mRNA exit channel to preclude
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04836	IFRD_C	450 → 503	Interferon-related protein conserved region	Family
  PF05004	IFRD	96 → 405	Interferon-related developmental regulator (IFRD)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9050919}.
• Sequence:

  MAWNSPSRRPVWQGGAPREDGGARGVWLPSSGQVSAQRTGRRLVGLEPTPTGSLTPRPPR
  PVPGMPRARKGNTLRKGGQRRGGGARSSAQADSGSSDDEAASEARSTASECPSLLSTTAE
  DSLGGDVVDEQGQQEDLEEKLKEYVDCLTDKSAKTRQGALESLRLALASRLLPDFLLERR
  LTLADALEKCLKKGKGEEQALAAAVLGLLCVQLGPGPKGEELFHSLQPLLVSVLSDSTAS
  PAARLHCASALGLGCYVAAADIQDLVSCLACLESVFSRFYGLGGSSTSPVVPASLHGLLS
  AALQAWALLLTICPSTQISHILDRQLPRLPQLLSSESVNLRIAAGETIALLFELARDLEE
  EFVYEDMEALCSVLRTLATDSNKYRAKADRRRQRSTFRAVLHSVEGGECEEEIVRFGFEV
  LYMDSWARHRIYAAFKEVLGSGMHHHLQNNELLRDIFGLGPVLLLDATALKACKVPRFEK
  HLYNAAAFKARTKARSRVRDKRADIL

• Sequence length: 506

Related Genes

No strongly related genes found yet for IFRD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to IFRD2.