IFIT5 (interferon induced protein with tetratricopeptide repeats 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 24138
• Gene name: Interferon induced protein with tetratricopeptide repeats 5
• Gene symbol: IFIT5
• Synonyms (NCBI Gene): ISG58, P58, RI58
• Chromosome: 10
• Chromosome location: 10q23.31

miRNA Show/Hide all (188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001624	hsa-let-7b-5p	pSILAC	18668040
MIRT020470	hsa-miR-106b-5p	Microarray	17242205
MIRT021272	hsa-miR-146a-5p	Microarray	18057241
MIRT001624	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT440465	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440465	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1060387	hsa-miR-129-5p	CLIP-seq
MIRT1060388	hsa-miR-142-5p	CLIP-seq
MIRT1060389	hsa-miR-203	CLIP-seq
MIRT1060390	hsa-miR-2116	CLIP-seq
MIRT1060391	hsa-miR-224	CLIP-seq
MIRT1060392	hsa-miR-3065-5p	CLIP-seq
MIRT1060393	hsa-miR-340	CLIP-seq
MIRT1060394	hsa-miR-3672	CLIP-seq
MIRT1060395	hsa-miR-3680	CLIP-seq
MIRT1060396	hsa-miR-3692	CLIP-seq
MIRT1060397	hsa-miR-376a	CLIP-seq
MIRT1060398	hsa-miR-376b	CLIP-seq
MIRT1060399	hsa-miR-4273	CLIP-seq
MIRT1060400	hsa-miR-448	CLIP-seq
MIRT1060401	hsa-miR-4677-5p	CLIP-seq
MIRT1060402	hsa-miR-4775	CLIP-seq
MIRT1060403	hsa-miR-4789-3p	CLIP-seq
MIRT1060404	hsa-miR-4795-3p	CLIP-seq
MIRT1060405	hsa-miR-548a-5p	CLIP-seq
MIRT1060406	hsa-miR-548ab	CLIP-seq
MIRT1060407	hsa-miR-548ak	CLIP-seq
MIRT1060408	hsa-miR-548b-5p	CLIP-seq
MIRT1060409	hsa-miR-548c-5p	CLIP-seq
MIRT1060410	hsa-miR-548d-5p	CLIP-seq
MIRT1060411	hsa-miR-548h	CLIP-seq
MIRT1060412	hsa-miR-548i	CLIP-seq
MIRT1060413	hsa-miR-548j	CLIP-seq
MIRT1060414	hsa-miR-548k	CLIP-seq
MIRT1060415	hsa-miR-548l	CLIP-seq
MIRT1060416	hsa-miR-548w	CLIP-seq
MIRT1060417	hsa-miR-548y	CLIP-seq
MIRT1060418	hsa-miR-559	CLIP-seq
MIRT1060419	hsa-miR-579	CLIP-seq
MIRT1060420	hsa-miR-582-5p	CLIP-seq
MIRT1060421	hsa-miR-587	CLIP-seq
MIRT1060422	hsa-miR-590-3p	CLIP-seq
MIRT1060423	hsa-miR-633	CLIP-seq
MIRT1060424	hsa-miR-664	CLIP-seq
MIRT1060425	hsa-miR-885-5p	CLIP-seq
MIRT1060426	hsa-miR-944	CLIP-seq
MIRT2014119	hsa-miR-4717-3p	CLIP-seq
MIRT1060424	hsa-miR-664	CLIP-seq
MIRT2246326	hsa-miR-4773	CLIP-seq
MIRT2389250	hsa-miR-136	CLIP-seq
MIRT2389251	hsa-miR-3163	CLIP-seq
MIRT2246326	hsa-miR-4773	CLIP-seq
MIRT2389252	hsa-miR-548ac	CLIP-seq
MIRT2389253	hsa-miR-548ae	CLIP-seq
MIRT2389254	hsa-miR-548aj	CLIP-seq
MIRT2389255	hsa-miR-548am	CLIP-seq
MIRT2389256	hsa-miR-548d-3p	CLIP-seq
MIRT2389257	hsa-miR-548x	CLIP-seq
MIRT2389258	hsa-miR-548z	CLIP-seq
MIRT2549749	hsa-miR-106a	CLIP-seq
MIRT2549750	hsa-miR-106b	CLIP-seq
MIRT2549751	hsa-miR-1233	CLIP-seq
MIRT2549752	hsa-miR-1303	CLIP-seq
MIRT2389250	hsa-miR-136	CLIP-seq
MIRT2549753	hsa-miR-150	CLIP-seq
MIRT2549754	hsa-miR-154	CLIP-seq
MIRT2549755	hsa-miR-17	CLIP-seq
MIRT2549756	hsa-miR-200b	CLIP-seq
MIRT2549757	hsa-miR-200c	CLIP-seq
MIRT2549758	hsa-miR-2054	CLIP-seq
MIRT2549759	hsa-miR-20a	CLIP-seq
MIRT2549760	hsa-miR-20b	CLIP-seq
MIRT2549761	hsa-miR-28-5p	CLIP-seq
MIRT1060392	hsa-miR-3065-5p	CLIP-seq
MIRT2549762	hsa-miR-3115	CLIP-seq
MIRT2549763	hsa-miR-3123	CLIP-seq
MIRT2549764	hsa-miR-3139	CLIP-seq
MIRT2549765	hsa-miR-3145-3p	CLIP-seq
MIRT2549766	hsa-miR-3162-5p	CLIP-seq
MIRT2389251	hsa-miR-3163	CLIP-seq
MIRT2549767	hsa-miR-323-3p	CLIP-seq
MIRT2549768	hsa-miR-331-3p	CLIP-seq
MIRT1060393	hsa-miR-340	CLIP-seq
MIRT2549769	hsa-miR-3613-3p	CLIP-seq
MIRT1060394	hsa-miR-3672	CLIP-seq
MIRT1060395	hsa-miR-3680	CLIP-seq
MIRT2549770	hsa-miR-3925-5p	CLIP-seq
MIRT2549771	hsa-miR-3973	CLIP-seq
MIRT2549772	hsa-miR-4266	CLIP-seq
MIRT2549773	hsa-miR-429	CLIP-seq
MIRT2549774	hsa-miR-4292	CLIP-seq
MIRT2549775	hsa-miR-4318	CLIP-seq
MIRT2549776	hsa-miR-4455	CLIP-seq
MIRT2549777	hsa-miR-4670-5p	CLIP-seq
MIRT2549778	hsa-miR-4679	CLIP-seq
MIRT2549779	hsa-miR-4687-5p	CLIP-seq
MIRT2549780	hsa-miR-4693-5p	CLIP-seq
MIRT2549781	hsa-miR-4695-5p	CLIP-seq
MIRT2549782	hsa-miR-4713-5p	CLIP-seq
MIRT2549783	hsa-miR-4760-5p	CLIP-seq
MIRT2549784	hsa-miR-4761-5p	CLIP-seq
MIRT2246326	hsa-miR-4773	CLIP-seq
MIRT1060402	hsa-miR-4775	CLIP-seq
MIRT2549785	hsa-miR-4778-3p	CLIP-seq
MIRT2549786	hsa-miR-4779	CLIP-seq
MIRT2549787	hsa-miR-4786-3p	CLIP-seq
MIRT1060404	hsa-miR-4795-3p	CLIP-seq
MIRT2549788	hsa-miR-503	CLIP-seq
MIRT2549789	hsa-miR-519d	CLIP-seq
MIRT2549790	hsa-miR-520g	CLIP-seq
MIRT2549791	hsa-miR-520h	CLIP-seq
MIRT2549792	hsa-miR-532-3p	CLIP-seq
MIRT2389252	hsa-miR-548ac	CLIP-seq
MIRT2389253	hsa-miR-548ae	CLIP-seq
MIRT2389254	hsa-miR-548aj	CLIP-seq
MIRT2389255	hsa-miR-548am	CLIP-seq
MIRT2549793	hsa-miR-548c-3p	CLIP-seq
MIRT2389256	hsa-miR-548d-3p	CLIP-seq
MIRT2389257	hsa-miR-548x	CLIP-seq
MIRT2389258	hsa-miR-548z	CLIP-seq
MIRT1060419	hsa-miR-579	CLIP-seq
MIRT1060421	hsa-miR-587	CLIP-seq
MIRT1060422	hsa-miR-590-3p	CLIP-seq
MIRT2549794	hsa-miR-604	CLIP-seq
MIRT2549795	hsa-miR-609	CLIP-seq
MIRT2549796	hsa-miR-647	CLIP-seq
MIRT1060424	hsa-miR-664	CLIP-seq
MIRT2549797	hsa-miR-708	CLIP-seq
MIRT2549798	hsa-miR-765	CLIP-seq
MIRT2549799	hsa-miR-802	CLIP-seq
MIRT1060425	hsa-miR-885-5p	CLIP-seq
MIRT2549800	hsa-miR-892a	CLIP-seq
MIRT2549801	hsa-miR-93	CLIP-seq
MIRT2549752	hsa-miR-1303	CLIP-seq
MIRT2389250	hsa-miR-136	CLIP-seq
MIRT2549753	hsa-miR-150	CLIP-seq
MIRT2549754	hsa-miR-154	CLIP-seq
MIRT2549756	hsa-miR-200b	CLIP-seq
MIRT2549757	hsa-miR-200c	CLIP-seq
MIRT2682630	hsa-miR-2110	CLIP-seq
MIRT2549761	hsa-miR-28-5p	CLIP-seq
MIRT2549762	hsa-miR-3115	CLIP-seq
MIRT2549763	hsa-miR-3123	CLIP-seq
MIRT2549764	hsa-miR-3139	CLIP-seq
MIRT2682631	hsa-miR-3150a-3p	CLIP-seq
MIRT2549766	hsa-miR-3162-5p	CLIP-seq
MIRT2389251	hsa-miR-3163	CLIP-seq
MIRT2549767	hsa-miR-323-3p	CLIP-seq
MIRT1060394	hsa-miR-3672	CLIP-seq
MIRT1060395	hsa-miR-3680	CLIP-seq
MIRT1060396	hsa-miR-3692	CLIP-seq
MIRT2549770	hsa-miR-3925-5p	CLIP-seq
MIRT2682632	hsa-miR-4260	CLIP-seq
MIRT2549772	hsa-miR-4266	CLIP-seq
MIRT2549773	hsa-miR-429	CLIP-seq
MIRT2549775	hsa-miR-4318	CLIP-seq
MIRT2682633	hsa-miR-4450	CLIP-seq
MIRT2549776	hsa-miR-4455	CLIP-seq
MIRT2549778	hsa-miR-4679	CLIP-seq
MIRT2549780	hsa-miR-4693-5p	CLIP-seq
MIRT2549781	hsa-miR-4695-5p	CLIP-seq
MIRT2549782	hsa-miR-4713-5p	CLIP-seq
MIRT2246326	hsa-miR-4773	CLIP-seq
MIRT1060402	hsa-miR-4775	CLIP-seq
MIRT2549785	hsa-miR-4778-3p	CLIP-seq
MIRT2549786	hsa-miR-4779	CLIP-seq
MIRT2549787	hsa-miR-4786-3p	CLIP-seq
MIRT2549792	hsa-miR-532-3p	CLIP-seq
MIRT2389252	hsa-miR-548ac	CLIP-seq
MIRT2389253	hsa-miR-548ae	CLIP-seq
MIRT2389254	hsa-miR-548aj	CLIP-seq
MIRT2389255	hsa-miR-548am	CLIP-seq
MIRT2389256	hsa-miR-548d-3p	CLIP-seq
MIRT2389257	hsa-miR-548x	CLIP-seq
MIRT2389258	hsa-miR-548z	CLIP-seq
MIRT1060419	hsa-miR-579	CLIP-seq
MIRT1060421	hsa-miR-587	CLIP-seq
MIRT1060422	hsa-miR-590-3p	CLIP-seq
MIRT2549794	hsa-miR-604	CLIP-seq
MIRT2549795	hsa-miR-609	CLIP-seq
MIRT2549796	hsa-miR-647	CLIP-seq
MIRT1060424	hsa-miR-664	CLIP-seq
MIRT2549797	hsa-miR-708	CLIP-seq
MIRT2549798	hsa-miR-765	CLIP-seq
MIRT2549799	hsa-miR-802	CLIP-seq
MIRT1060425	hsa-miR-885-5p	CLIP-seq
MIRT2549800	hsa-miR-892a	CLIP-seq
MIRT1060426	hsa-miR-944	CLIP-seq

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IDA	23317505
GO:0000049	Function	TRNA binding	IEA
GO:0000339	Function	RNA cap binding	IDA	25092312
GO:0002376	Process	Immune system process	IEA
GO:0003690	Function	Double-stranded DNA binding	IDA	23774268
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	21642987
GO:0003723	Function	RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IDA	23334420, 23774268, 25092312
GO:0005515	Function	Protein binding	IPI	26334375
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0008266	Function	Poly(U) RNA binding	IDA	25092312
GO:0008385	Component	IkappaB kinase complex	IMP	26334375
GO:0015629	Component	Actin cytoskeleton	IDA	23317505
GO:0016020	Component	Membrane	IEA
GO:0032587	Component	Ruffle membrane	IDA	23317505
GO:0032587	Component	Ruffle membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	26334375
GO:0045071	Process	Negative regulation of viral genome replication	IDA	23774268
GO:0045087	Process	Innate immune response	IEA
GO:0045177	Component	Apical part of cell	IDA	23317505
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	IMP	23334420

Other IDs

• MIM: 616135
• HGNC: 13328
• e!Ensembl: ENSG00000152778

Protein

• UniProt ID: Q13325
• Protein name: Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
• Protein function: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well
• PDB: 3ZGQ , 4HOQ , 4HOR , 4HOS , 4HOT , 4J0U
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13181	TPR_8	147 → 173	Tetratricopeptide repeat	Repeat
  PF13374	TPR_10	337 → 369		Repeat
  PF13424	TPR_12	49 → 117		Repeat

• Sequence:

  MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYV
  KHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKI
  GNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGY
  AITVYRLDDSDREGSVKSFSLGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEE
  ILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQI
  KKATHNRPKGKDKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDI
  FRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSAL
  KKLSTKRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPENAEFLTALCELRL
  SI

• Sequence length: 482

Related Genes

No strongly related genes found yet for IFIT5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to IFIT5.