IFIT2 (interferon induced protein with tetratricopeptide repeats 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 3433
• Gene name: Interferon induced protein with tetratricopeptide repeats 2
• Gene symbol: IFIT2
• Synonyms (NCBI Gene): G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54, ISG-54 K, ISG-54K, ISG54, P54, cig42
• Chromosome: 10
• Chromosome location: 10q23.31

miRNA Show/Hide all (207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022752	hsa-miR-124-3p	Microarray	18668037
MIRT023835	hsa-miR-1-3p	Microarray	18668037
MIRT054140	hsa-miR-645	Immunohistochemistry, Luciferase reporter assay, Mass spectrometry, qRT-PCR, Western blot	25174799
MIRT054140	hsa-miR-645	Immunohistochemistry, Luciferase reporter assay, Mass spectrometry, qRT-PCR, Western blot	25174799
MIRT054287	hsa-miR-193b-5p	Microarray, qRT-PCR	22752226
MIRT1060323	hsa-miR-1913	CLIP-seq
MIRT1060324	hsa-miR-2117	CLIP-seq
MIRT1060325	hsa-miR-3150b-3p	CLIP-seq
MIRT1060326	hsa-miR-324-3p	CLIP-seq
MIRT1060327	hsa-miR-3616-3p	CLIP-seq
MIRT1060328	hsa-miR-371-5p	CLIP-seq
MIRT1060329	hsa-miR-371b-5p	CLIP-seq
MIRT1060330	hsa-miR-4273	CLIP-seq
MIRT1060331	hsa-miR-4290	CLIP-seq
MIRT1060332	hsa-miR-4436b-3p	CLIP-seq
MIRT1060333	hsa-miR-4655-3p	CLIP-seq
MIRT1060334	hsa-miR-4689	CLIP-seq
MIRT1060335	hsa-miR-4779	CLIP-seq
MIRT1060336	hsa-miR-4784	CLIP-seq
MIRT2014111	hsa-miR-1206	CLIP-seq
MIRT2014112	hsa-miR-433	CLIP-seq
MIRT2014113	hsa-miR-4422	CLIP-seq
MIRT2014111	hsa-miR-1206	CLIP-seq
MIRT2246322	hsa-miR-1228	CLIP-seq
MIRT2246323	hsa-miR-2964a-5p	CLIP-seq
MIRT2246324	hsa-miR-377	CLIP-seq
MIRT2014112	hsa-miR-433	CLIP-seq
MIRT2014113	hsa-miR-4422	CLIP-seq
MIRT2246325	hsa-miR-659	CLIP-seq
MIRT2246322	hsa-miR-1228	CLIP-seq
MIRT1060323	hsa-miR-1913	CLIP-seq
MIRT1060324	hsa-miR-2117	CLIP-seq
MIRT1060326	hsa-miR-324-3p	CLIP-seq
MIRT1060328	hsa-miR-371-5p	CLIP-seq
MIRT1060329	hsa-miR-371b-5p	CLIP-seq
MIRT2246324	hsa-miR-377	CLIP-seq
MIRT2389249	hsa-miR-3924	CLIP-seq
MIRT1060330	hsa-miR-4273	CLIP-seq
MIRT2246325	hsa-miR-659	CLIP-seq
MIRT1060332	hsa-miR-4436b-3p	CLIP-seq
MIRT2549581	hsa-miR-105	CLIP-seq
MIRT2549582	hsa-miR-10a	CLIP-seq
MIRT2549583	hsa-miR-10b	CLIP-seq
MIRT2014111	hsa-miR-1206	CLIP-seq
MIRT2549584	hsa-miR-1226	CLIP-seq
MIRT2246322	hsa-miR-1228	CLIP-seq
MIRT2549585	hsa-miR-1252	CLIP-seq
MIRT2549586	hsa-miR-125a-3p	CLIP-seq
MIRT2549587	hsa-miR-1260	CLIP-seq
MIRT2549588	hsa-miR-1260b	CLIP-seq
MIRT2549589	hsa-miR-151-3p	CLIP-seq
MIRT2549590	hsa-miR-1825	CLIP-seq
MIRT2549591	hsa-miR-1827	CLIP-seq
MIRT2549592	hsa-miR-188-3p	CLIP-seq
MIRT2549593	hsa-miR-198	CLIP-seq
MIRT2549594	hsa-miR-199a-5p	CLIP-seq
MIRT2549595	hsa-miR-199b-5p	CLIP-seq
MIRT2549596	hsa-miR-2113	CLIP-seq
MIRT2549597	hsa-miR-216a	CLIP-seq
MIRT2549598	hsa-miR-23a	CLIP-seq
MIRT2549599	hsa-miR-23b	CLIP-seq
MIRT2549600	hsa-miR-23c	CLIP-seq
MIRT2246323	hsa-miR-2964a-5p	CLIP-seq
MIRT2549601	hsa-miR-3074-3p	CLIP-seq
MIRT2549602	hsa-miR-3124-3p	CLIP-seq
MIRT2549603	hsa-miR-3143	CLIP-seq
MIRT2549604	hsa-miR-3145-5p	CLIP-seq
MIRT2549605	hsa-miR-3156-3p	CLIP-seq
MIRT2549606	hsa-miR-3160-5p	CLIP-seq
MIRT2549607	hsa-miR-3173-3p	CLIP-seq
MIRT2549608	hsa-miR-339-5p	CLIP-seq
MIRT2549609	hsa-miR-34c-3p	CLIP-seq
MIRT2549610	hsa-miR-3612	CLIP-seq
MIRT2549611	hsa-miR-3613-3p	CLIP-seq
MIRT2549612	hsa-miR-3620	CLIP-seq
MIRT2549613	hsa-miR-3667-5p	CLIP-seq
MIRT2549614	hsa-miR-3677-5p	CLIP-seq
MIRT2549615	hsa-miR-3682-3p	CLIP-seq
MIRT2549616	hsa-miR-3685	CLIP-seq
MIRT2549617	hsa-miR-3688-3p	CLIP-seq
MIRT2549618	hsa-miR-3691-3p	CLIP-seq
MIRT1060328	hsa-miR-371-5p	CLIP-seq
MIRT1060329	hsa-miR-371b-5p	CLIP-seq
MIRT2549619	hsa-miR-374c	CLIP-seq
MIRT2246324	hsa-miR-377	CLIP-seq
MIRT2549620	hsa-miR-384	CLIP-seq
MIRT2549621	hsa-miR-3934	CLIP-seq
MIRT2549622	hsa-miR-410	CLIP-seq
MIRT2549623	hsa-miR-4269	CLIP-seq
MIRT2549624	hsa-miR-4275	CLIP-seq
MIRT2549625	hsa-miR-4289	CLIP-seq
MIRT2549626	hsa-miR-4291	CLIP-seq
MIRT2549627	hsa-miR-4310	CLIP-seq
MIRT2014112	hsa-miR-433	CLIP-seq
MIRT2549628	hsa-miR-4330	CLIP-seq
MIRT2014113	hsa-miR-4422	CLIP-seq
MIRT2549629	hsa-miR-4424	CLIP-seq
MIRT2549630	hsa-miR-4435	CLIP-seq
MIRT2549631	hsa-miR-4452	CLIP-seq
MIRT2549632	hsa-miR-4463	CLIP-seq
MIRT2549633	hsa-miR-4476	CLIP-seq
MIRT2549634	hsa-miR-4499	CLIP-seq
MIRT2549635	hsa-miR-4502	CLIP-seq
MIRT2549636	hsa-miR-450b-5p	CLIP-seq
MIRT2549637	hsa-miR-4514	CLIP-seq
MIRT2549638	hsa-miR-4522	CLIP-seq
MIRT2549639	hsa-miR-4533	CLIP-seq
MIRT2549640	hsa-miR-4646-5p	CLIP-seq
MIRT2549641	hsa-miR-4653-3p	CLIP-seq
MIRT2549642	hsa-miR-4666-5p	CLIP-seq
MIRT2549643	hsa-miR-4692	CLIP-seq
MIRT2549644	hsa-miR-4694-3p	CLIP-seq
MIRT2549645	hsa-miR-4694-5p	CLIP-seq
MIRT2549646	hsa-miR-4695-5p	CLIP-seq
MIRT2549647	hsa-miR-4699-5p	CLIP-seq
MIRT2549648	hsa-miR-4715-3p	CLIP-seq
MIRT2549649	hsa-miR-4733-3p	CLIP-seq
MIRT2549650	hsa-miR-4742-5p	CLIP-seq
MIRT2549651	hsa-miR-4747-5p	CLIP-seq
MIRT2549652	hsa-miR-4756-3p	CLIP-seq
MIRT2549653	hsa-miR-4761-5p	CLIP-seq
MIRT2549654	hsa-miR-4797-5p	CLIP-seq
MIRT2549655	hsa-miR-4803	CLIP-seq
MIRT2549656	hsa-miR-502-5p	CLIP-seq
MIRT2549657	hsa-miR-507	CLIP-seq
MIRT2549658	hsa-miR-518a-5p	CLIP-seq
MIRT2549659	hsa-miR-520d-5p	CLIP-seq
MIRT2549660	hsa-miR-524-5p	CLIP-seq
MIRT2549661	hsa-miR-527	CLIP-seq
MIRT2549662	hsa-miR-557	CLIP-seq
MIRT2549663	hsa-miR-579	CLIP-seq
MIRT2549664	hsa-miR-604	CLIP-seq
MIRT2549665	hsa-miR-622	CLIP-seq
MIRT2549666	hsa-miR-633	CLIP-seq
MIRT2549667	hsa-miR-647	CLIP-seq
MIRT2549668	hsa-miR-655	CLIP-seq
MIRT2246325	hsa-miR-659	CLIP-seq
MIRT2549669	hsa-miR-662	CLIP-seq
MIRT2549670	hsa-miR-758	CLIP-seq
MIRT2549671	hsa-miR-764	CLIP-seq
MIRT2549672	hsa-miR-765	CLIP-seq
MIRT2549673	hsa-miR-767-5p	CLIP-seq
MIRT2549674	hsa-miR-873	CLIP-seq
MIRT2549675	hsa-miR-888	CLIP-seq
MIRT2549676	hsa-miR-889	CLIP-seq
MIRT2549677	hsa-miR-936	CLIP-seq
MIRT2549678	hsa-miR-938	CLIP-seq
MIRT2549581	hsa-miR-105	CLIP-seq
MIRT2014111	hsa-miR-1206	CLIP-seq
MIRT2549584	hsa-miR-1226	CLIP-seq
MIRT2246322	hsa-miR-1228	CLIP-seq
MIRT2549585	hsa-miR-1252	CLIP-seq
MIRT2549587	hsa-miR-1260	CLIP-seq
MIRT2549588	hsa-miR-1260b	CLIP-seq
MIRT2549592	hsa-miR-188-3p	CLIP-seq
MIRT2549596	hsa-miR-2113	CLIP-seq
MIRT2549597	hsa-miR-216a	CLIP-seq
MIRT2246323	hsa-miR-2964a-5p	CLIP-seq
MIRT2549601	hsa-miR-3074-3p	CLIP-seq
MIRT2549602	hsa-miR-3124-3p	CLIP-seq
MIRT2549604	hsa-miR-3145-5p	CLIP-seq
MIRT2549605	hsa-miR-3156-3p	CLIP-seq
MIRT2549606	hsa-miR-3160-5p	CLIP-seq
MIRT2549609	hsa-miR-34c-3p	CLIP-seq
MIRT2549611	hsa-miR-3613-3p	CLIP-seq
MIRT2549612	hsa-miR-3620	CLIP-seq
MIRT2549616	hsa-miR-3685	CLIP-seq
MIRT2549617	hsa-miR-3688-3p	CLIP-seq
MIRT2549618	hsa-miR-3691-3p	CLIP-seq
MIRT1060328	hsa-miR-371-5p	CLIP-seq
MIRT1060329	hsa-miR-371b-5p	CLIP-seq
MIRT2246324	hsa-miR-377	CLIP-seq
MIRT2549620	hsa-miR-384	CLIP-seq
MIRT2549622	hsa-miR-410	CLIP-seq
MIRT2549626	hsa-miR-4291	CLIP-seq
MIRT2549627	hsa-miR-4310	CLIP-seq
MIRT2014112	hsa-miR-433	CLIP-seq
MIRT2549628	hsa-miR-4330	CLIP-seq
MIRT2014113	hsa-miR-4422	CLIP-seq
MIRT2549629	hsa-miR-4424	CLIP-seq
MIRT2549635	hsa-miR-4502	CLIP-seq
MIRT2549636	hsa-miR-450b-5p	CLIP-seq
MIRT2549638	hsa-miR-4522	CLIP-seq
MIRT2549641	hsa-miR-4653-3p	CLIP-seq
MIRT2549642	hsa-miR-4666-5p	CLIP-seq
MIRT2549644	hsa-miR-4694-3p	CLIP-seq
MIRT2549647	hsa-miR-4699-5p	CLIP-seq
MIRT2549649	hsa-miR-4733-3p	CLIP-seq
MIRT2549654	hsa-miR-4797-5p	CLIP-seq
MIRT2549656	hsa-miR-502-5p	CLIP-seq
MIRT2549657	hsa-miR-507	CLIP-seq
MIRT2549658	hsa-miR-518a-5p	CLIP-seq
MIRT2549659	hsa-miR-520d-5p	CLIP-seq
MIRT2549660	hsa-miR-524-5p	CLIP-seq
MIRT2549661	hsa-miR-527	CLIP-seq
MIRT2549662	hsa-miR-557	CLIP-seq
MIRT2549663	hsa-miR-579	CLIP-seq
MIRT2549664	hsa-miR-604	CLIP-seq
MIRT2549665	hsa-miR-622	CLIP-seq
MIRT2549667	hsa-miR-647	CLIP-seq
MIRT2246325	hsa-miR-659	CLIP-seq
MIRT2549669	hsa-miR-662	CLIP-seq
MIRT2549670	hsa-miR-758	CLIP-seq
MIRT2549673	hsa-miR-767-5p	CLIP-seq
MIRT2549674	hsa-miR-873	CLIP-seq
MIRT2549676	hsa-miR-889	CLIP-seq
MIRT2549678	hsa-miR-938	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	19416887, 21190939, 21642987, 28514442, 31515488, 33961781
GO:0005737	Component	Cytoplasm	IDA	21190939
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	21190939
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0008637	Process	Apoptotic mitochondrial changes	TAS	21190939
GO:0009615	Process	Response to virus	IDA	19416887
GO:0009615	Process	Response to virus	IMP	21642987
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21190939
GO:0045087	Process	Innate immune response	IEA
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0140374	Process	Antiviral innate immune response	IDA	19416887

Other IDs

• MIM: 147040
• HGNC: 5409
• e!Ensembl: ENSG00000119922

Protein

• UniProt ID: P09913
• Protein name: Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)
• Protein function: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host du
• PDB: 4G1T
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13181	TPR_8	51 → 84	Tetratricopeptide repeat	Repeat
  PF13181	TPR_8	252 → 280	Tetratricopeptide repeat	Repeat

• Sequence:

  MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYL
  KHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKV
  KHVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAI
  ASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEAL
  EKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKVFQVMN
  LRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKE
  FSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAK
  MRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE

• Sequence length: 472

Pathways

Reactome Pathway:

Interferon alpha/beta signaling

Related Genes

No strongly related genes found yet for IFIT2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to IFIT2.