Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	3419
Gene name	Isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
Gene symbol	IDH3A
Synonyms (NCBI Gene)	RP90
Chromosome	15
Chromosome location	15q25.1
Summary	Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases

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SNP ID	Visualize variation	Clinical significance	Consequence
rs149862950	T>C	Pathogenic	Missense variant, coding sequence variant
rs756712426	C>A	Pathogenic	Missense variant, coding sequence variant

338

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031744	hsa-miR-16-5p	Proteomics	18668040
MIRT459786	hsa-miR-3154	PAR-CLIP	23592263
MIRT459784	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT459783	hsa-miR-3125	PAR-CLIP	23592263
MIRT459782	hsa-miR-3916	PAR-CLIP	23592263
MIRT459781	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT459780	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT459779	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT459778	hsa-miR-922	PAR-CLIP	23592263
MIRT459777	hsa-miR-1184	PAR-CLIP	23592263
MIRT459776	hsa-miR-7515	PAR-CLIP	23592263
MIRT459775	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT459774	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT459772	hsa-miR-4784	PAR-CLIP	23592263
MIRT459773	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT459771	hsa-miR-107	PAR-CLIP	23592263
MIRT459770	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT459769	hsa-miR-4434	PAR-CLIP	23592263
MIRT459768	hsa-miR-4516	PAR-CLIP	23592263
MIRT459767	hsa-miR-5703	PAR-CLIP	23592263
MIRT459766	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT459765	hsa-miR-8085	PAR-CLIP	23592263
MIRT459786	hsa-miR-3154	PAR-CLIP	23592263
MIRT459784	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT459783	hsa-miR-3125	PAR-CLIP	23592263
MIRT459782	hsa-miR-3916	PAR-CLIP	23592263
MIRT459781	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT459780	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT459779	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT459778	hsa-miR-922	PAR-CLIP	23592263
MIRT459777	hsa-miR-1184	PAR-CLIP	23592263
MIRT459776	hsa-miR-7515	PAR-CLIP	23592263
MIRT459775	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT459774	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT459772	hsa-miR-4784	PAR-CLIP	23592263
MIRT459773	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT459771	hsa-miR-107	PAR-CLIP	23592263
MIRT459770	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT459769	hsa-miR-4434	PAR-CLIP	23592263
MIRT459768	hsa-miR-4516	PAR-CLIP	23592263
MIRT459767	hsa-miR-5703	PAR-CLIP	23592263
MIRT459766	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT459765	hsa-miR-8085	PAR-CLIP	23592263
MIRT1059316	hsa-miR-103a	CLIP-seq
MIRT1059317	hsa-miR-1206	CLIP-seq
MIRT1059318	hsa-miR-1915	CLIP-seq
MIRT1059319	hsa-miR-2467-3p	CLIP-seq
MIRT1059320	hsa-miR-3120-5p	CLIP-seq
MIRT1059321	hsa-miR-3171	CLIP-seq
MIRT1059322	hsa-miR-3174	CLIP-seq
MIRT1059323	hsa-miR-3607-3p	CLIP-seq
MIRT1059324	hsa-miR-3647-3p	CLIP-seq
MIRT1059325	hsa-miR-3653	CLIP-seq
MIRT1059326	hsa-miR-3658	CLIP-seq
MIRT1059327	hsa-miR-3659	CLIP-seq
MIRT1059328	hsa-miR-3674	CLIP-seq
MIRT1059329	hsa-miR-3686	CLIP-seq
MIRT1059330	hsa-miR-433	CLIP-seq
MIRT1059331	hsa-miR-4495	CLIP-seq
MIRT1059332	hsa-miR-4641	CLIP-seq
MIRT1059333	hsa-miR-4652-3p	CLIP-seq
MIRT1059334	hsa-miR-4658	CLIP-seq
MIRT1059335	hsa-miR-4699-5p	CLIP-seq
MIRT1059336	hsa-miR-4726-3p	CLIP-seq
MIRT1059337	hsa-miR-4753-3p	CLIP-seq
MIRT1059338	hsa-miR-4762-5p	CLIP-seq
MIRT1059339	hsa-miR-574-5p	CLIP-seq
MIRT1059340	hsa-miR-581	CLIP-seq
MIRT1059341	hsa-miR-593	CLIP-seq
MIRT1059342	hsa-miR-921	CLIP-seq
MIRT2013836	hsa-miR-1324	CLIP-seq
MIRT2013837	hsa-miR-142-3p	CLIP-seq
MIRT2013838	hsa-miR-219-1-3p	CLIP-seq
MIRT2013839	hsa-miR-3065-5p	CLIP-seq
MIRT2013840	hsa-miR-3120-3p	CLIP-seq
MIRT2013841	hsa-miR-323b-5p	CLIP-seq
MIRT1059324	hsa-miR-3647-3p	CLIP-seq
MIRT2013842	hsa-miR-4265	CLIP-seq
MIRT2013843	hsa-miR-4296	CLIP-seq
MIRT2013844	hsa-miR-432	CLIP-seq
MIRT2013845	hsa-miR-4322	CLIP-seq
MIRT2013846	hsa-miR-4696	CLIP-seq
MIRT2013847	hsa-miR-511	CLIP-seq
MIRT2013848	hsa-miR-571	CLIP-seq
MIRT2013849	hsa-miR-587	CLIP-seq
MIRT2013850	hsa-miR-648	CLIP-seq
MIRT2013851	hsa-miR-659	CLIP-seq
MIRT2013852	hsa-miR-9	CLIP-seq
MIRT2246001	hsa-miR-1	CLIP-seq
MIRT2013836	hsa-miR-1324	CLIP-seq
MIRT2246002	hsa-miR-15a	CLIP-seq
MIRT2246003	hsa-miR-15b	CLIP-seq
MIRT2246004	hsa-miR-16	CLIP-seq
MIRT2246005	hsa-miR-195	CLIP-seq
MIRT2246006	hsa-miR-206	CLIP-seq
MIRT2013838	hsa-miR-219-1-3p	CLIP-seq
MIRT2013840	hsa-miR-3120-3p	CLIP-seq
MIRT2246007	hsa-miR-3152-5p	CLIP-seq
MIRT2246008	hsa-miR-3673	CLIP-seq
MIRT2246009	hsa-miR-3925-3p	CLIP-seq
MIRT2246010	hsa-miR-424	CLIP-seq
MIRT2246011	hsa-miR-4423-5p	CLIP-seq
MIRT2246012	hsa-miR-450b-5p	CLIP-seq
MIRT2246013	hsa-miR-4682	CLIP-seq
MIRT2013846	hsa-miR-4696	CLIP-seq
MIRT2246014	hsa-miR-494	CLIP-seq
MIRT2246015	hsa-miR-497	CLIP-seq
MIRT2246016	hsa-miR-507	CLIP-seq
MIRT2246017	hsa-miR-557	CLIP-seq
MIRT2013848	hsa-miR-571	CLIP-seq
MIRT2246018	hsa-miR-613	CLIP-seq
MIRT2246019	hsa-miR-646	CLIP-seq
MIRT2013852	hsa-miR-9	CLIP-seq
MIRT1059317	hsa-miR-1206	CLIP-seq
MIRT2549073	hsa-miR-1225-5p	CLIP-seq
MIRT2549074	hsa-miR-1237	CLIP-seq
MIRT2549075	hsa-miR-1264	CLIP-seq
MIRT2549076	hsa-miR-1277	CLIP-seq
MIRT2549077	hsa-miR-129-3p	CLIP-seq
MIRT2549078	hsa-miR-1322	CLIP-seq
MIRT2013836	hsa-miR-1324	CLIP-seq
MIRT2549079	hsa-miR-149	CLIP-seq
MIRT2246002	hsa-miR-15a	CLIP-seq
MIRT2246003	hsa-miR-15b	CLIP-seq
MIRT2246004	hsa-miR-16	CLIP-seq
MIRT2549080	hsa-miR-1825	CLIP-seq
MIRT2549081	hsa-miR-1827	CLIP-seq
MIRT2549082	hsa-miR-186	CLIP-seq
MIRT2246005	hsa-miR-195	CLIP-seq
MIRT2549083	hsa-miR-199a-5p	CLIP-seq
MIRT2549084	hsa-miR-199b-5p	CLIP-seq
MIRT2549085	hsa-miR-216a	CLIP-seq
MIRT2013838	hsa-miR-219-1-3p	CLIP-seq
MIRT1059319	hsa-miR-2467-3p	CLIP-seq
MIRT2549086	hsa-miR-3064-5p	CLIP-seq
MIRT2549087	hsa-miR-3122	CLIP-seq
MIRT2549088	hsa-miR-3127-3p	CLIP-seq
MIRT1059321	hsa-miR-3171	CLIP-seq
MIRT2549089	hsa-miR-3173-3p	CLIP-seq
MIRT2549090	hsa-miR-3179	CLIP-seq
MIRT2549091	hsa-miR-3180	CLIP-seq
MIRT2549092	hsa-miR-3180-3p	CLIP-seq
MIRT2549093	hsa-miR-3196	CLIP-seq
MIRT2549094	hsa-miR-331-5p	CLIP-seq
MIRT2549095	hsa-miR-338-3p	CLIP-seq
MIRT2549096	hsa-miR-3607-5p	CLIP-seq
MIRT2549097	hsa-miR-3613-3p	CLIP-seq
MIRT2549098	hsa-miR-3616-3p	CLIP-seq
MIRT2549099	hsa-miR-3646	CLIP-seq
MIRT1059324	hsa-miR-3647-3p	CLIP-seq
MIRT1059326	hsa-miR-3658	CLIP-seq
MIRT2549100	hsa-miR-3661	CLIP-seq
MIRT2549101	hsa-miR-3662	CLIP-seq
MIRT1059328	hsa-miR-3674	CLIP-seq
MIRT2549102	hsa-miR-3713	CLIP-seq
MIRT2549103	hsa-miR-3907	CLIP-seq
MIRT2549104	hsa-miR-3913-5p	CLIP-seq
MIRT2549105	hsa-miR-3926	CLIP-seq
MIRT2549106	hsa-miR-3941	CLIP-seq
MIRT2549107	hsa-miR-3942-3p	CLIP-seq
MIRT2549108	hsa-miR-3977	CLIP-seq
MIRT2549109	hsa-miR-3978	CLIP-seq
MIRT2246010	hsa-miR-424	CLIP-seq
MIRT2549110	hsa-miR-4257	CLIP-seq
MIRT2549111	hsa-miR-4317	CLIP-seq
MIRT2013844	hsa-miR-432	CLIP-seq
MIRT2549112	hsa-miR-4323	CLIP-seq
MIRT1059330	hsa-miR-433	CLIP-seq
MIRT2549113	hsa-miR-4436b-3p	CLIP-seq
MIRT2549114	hsa-miR-4457	CLIP-seq
MIRT2549115	hsa-miR-4464	CLIP-seq
MIRT2549116	hsa-miR-4488	CLIP-seq
MIRT1059331	hsa-miR-4495	CLIP-seq
MIRT2549117	hsa-miR-4504	CLIP-seq
MIRT2549118	hsa-miR-450b-3p	CLIP-seq
MIRT2246012	hsa-miR-450b-5p	CLIP-seq
MIRT2549119	hsa-miR-455-3p	CLIP-seq
MIRT2549120	hsa-miR-4639-5p	CLIP-seq
MIRT2549121	hsa-miR-4649-3p	CLIP-seq
MIRT2549122	hsa-miR-466	CLIP-seq
MIRT2549123	hsa-miR-4661-5p	CLIP-seq
MIRT2549124	hsa-miR-4663	CLIP-seq
MIRT2549125	hsa-miR-4667-5p	CLIP-seq
MIRT2549126	hsa-miR-4668-3p	CLIP-seq
MIRT2549127	hsa-miR-4672	CLIP-seq
MIRT2549128	hsa-miR-4678	CLIP-seq
MIRT2549129	hsa-miR-4690-3p	CLIP-seq
MIRT2549130	hsa-miR-4695-5p	CLIP-seq
MIRT2549131	hsa-miR-4697-5p	CLIP-seq
MIRT2549132	hsa-miR-4700-5p	CLIP-seq
MIRT2549133	hsa-miR-4728-3p	CLIP-seq
MIRT2549134	hsa-miR-4731-3p	CLIP-seq
MIRT2549135	hsa-miR-4748	CLIP-seq
MIRT2549136	hsa-miR-4772-5p	CLIP-seq
MIRT2549137	hsa-miR-4794	CLIP-seq
MIRT2549138	hsa-miR-4799-5p	CLIP-seq
MIRT2549139	hsa-miR-4801	CLIP-seq
MIRT2246014	hsa-miR-494	CLIP-seq
MIRT2246015	hsa-miR-497	CLIP-seq
MIRT2246016	hsa-miR-507	CLIP-seq
MIRT2013847	hsa-miR-511	CLIP-seq
MIRT2549140	hsa-miR-513c	CLIP-seq
MIRT2549141	hsa-miR-514b-5p	CLIP-seq
MIRT2549142	hsa-miR-518a-5p	CLIP-seq
MIRT2549143	hsa-miR-520d-5p	CLIP-seq
MIRT2549144	hsa-miR-524-5p	CLIP-seq
MIRT2549145	hsa-miR-527	CLIP-seq
MIRT2549146	hsa-miR-542-3p	CLIP-seq
MIRT2549147	hsa-miR-548c-3p	CLIP-seq
MIRT2549148	hsa-miR-549	CLIP-seq
MIRT2246017	hsa-miR-557	CLIP-seq
MIRT2013848	hsa-miR-571	CLIP-seq
MIRT2549149	hsa-miR-605	CLIP-seq
MIRT2549150	hsa-miR-630	CLIP-seq
MIRT2549151	hsa-miR-631	CLIP-seq
MIRT2549152	hsa-miR-637	CLIP-seq
MIRT2246019	hsa-miR-646	CLIP-seq
MIRT2549153	hsa-miR-758	CLIP-seq
MIRT2549154	hsa-miR-759	CLIP-seq
MIRT2549155	hsa-miR-769-3p	CLIP-seq
MIRT1059317	hsa-miR-1206	CLIP-seq
MIRT2549073	hsa-miR-1225-5p	CLIP-seq
MIRT2549074	hsa-miR-1237	CLIP-seq
MIRT2549075	hsa-miR-1264	CLIP-seq
MIRT2549076	hsa-miR-1277	CLIP-seq
MIRT2549077	hsa-miR-129-3p	CLIP-seq
MIRT2549078	hsa-miR-1322	CLIP-seq
MIRT2013836	hsa-miR-1324	CLIP-seq
MIRT2549079	hsa-miR-149	CLIP-seq
MIRT2246002	hsa-miR-15a	CLIP-seq
MIRT2246003	hsa-miR-15b	CLIP-seq
MIRT2246004	hsa-miR-16	CLIP-seq
MIRT2549080	hsa-miR-1825	CLIP-seq
MIRT2549082	hsa-miR-186	CLIP-seq
MIRT2246005	hsa-miR-195	CLIP-seq
MIRT2549083	hsa-miR-199a-5p	CLIP-seq
MIRT2549084	hsa-miR-199b-5p	CLIP-seq
MIRT2549085	hsa-miR-216a	CLIP-seq
MIRT2013838	hsa-miR-219-1-3p	CLIP-seq
MIRT2549086	hsa-miR-3064-5p	CLIP-seq
MIRT2013839	hsa-miR-3065-5p	CLIP-seq
MIRT2549088	hsa-miR-3127-3p	CLIP-seq
MIRT2682570	hsa-miR-3144-5p	CLIP-seq
MIRT2682571	hsa-miR-3151	CLIP-seq
MIRT2682572	hsa-miR-3153	CLIP-seq
MIRT1059321	hsa-miR-3171	CLIP-seq
MIRT2549089	hsa-miR-3173-3p	CLIP-seq
MIRT2549091	hsa-miR-3180	CLIP-seq
MIRT2549092	hsa-miR-3180-3p	CLIP-seq
MIRT2682573	hsa-miR-3191	CLIP-seq
MIRT2549093	hsa-miR-3196	CLIP-seq
MIRT2682574	hsa-miR-3202	CLIP-seq
MIRT2013841	hsa-miR-323b-5p	CLIP-seq
MIRT2549094	hsa-miR-331-5p	CLIP-seq
MIRT2549095	hsa-miR-338-3p	CLIP-seq
MIRT2682575	hsa-miR-3529	CLIP-seq
MIRT2549096	hsa-miR-3607-5p	CLIP-seq
MIRT2549097	hsa-miR-3613-3p	CLIP-seq
MIRT2549099	hsa-miR-3646	CLIP-seq
MIRT1059324	hsa-miR-3647-3p	CLIP-seq
MIRT1059326	hsa-miR-3658	CLIP-seq
MIRT2549100	hsa-miR-3661	CLIP-seq
MIRT2549101	hsa-miR-3662	CLIP-seq
MIRT1059328	hsa-miR-3674	CLIP-seq
MIRT2549102	hsa-miR-3713	CLIP-seq
MIRT2682576	hsa-miR-379	CLIP-seq
MIRT2549105	hsa-miR-3926	CLIP-seq
MIRT2682577	hsa-miR-3927	CLIP-seq
MIRT2549106	hsa-miR-3941	CLIP-seq
MIRT2549107	hsa-miR-3942-3p	CLIP-seq
MIRT2549108	hsa-miR-3977	CLIP-seq
MIRT2549109	hsa-miR-3978	CLIP-seq
MIRT2246010	hsa-miR-424	CLIP-seq
MIRT2549110	hsa-miR-4257	CLIP-seq
MIRT2013842	hsa-miR-4265	CLIP-seq
MIRT2013843	hsa-miR-4296	CLIP-seq
MIRT2549111	hsa-miR-4317	CLIP-seq
MIRT2013844	hsa-miR-432	CLIP-seq
MIRT2013845	hsa-miR-4322	CLIP-seq
MIRT2549112	hsa-miR-4323	CLIP-seq
MIRT1059330	hsa-miR-433	CLIP-seq
MIRT2682578	hsa-miR-4428	CLIP-seq
MIRT2682579	hsa-miR-4447	CLIP-seq
MIRT2549114	hsa-miR-4457	CLIP-seq
MIRT2549115	hsa-miR-4464	CLIP-seq
MIRT2682580	hsa-miR-4472	CLIP-seq
MIRT2682581	hsa-miR-4476	CLIP-seq
MIRT2549116	hsa-miR-4488	CLIP-seq
MIRT1059331	hsa-miR-4495	CLIP-seq
MIRT2246012	hsa-miR-450b-5p	CLIP-seq
MIRT2549119	hsa-miR-455-3p	CLIP-seq
MIRT2549120	hsa-miR-4639-5p	CLIP-seq
MIRT2682582	hsa-miR-4652-5p	CLIP-seq
MIRT2549122	hsa-miR-466	CLIP-seq
MIRT2549123	hsa-miR-4661-5p	CLIP-seq
MIRT2549124	hsa-miR-4663	CLIP-seq
MIRT2549125	hsa-miR-4667-5p	CLIP-seq
MIRT2549126	hsa-miR-4668-3p	CLIP-seq
MIRT2549127	hsa-miR-4672	CLIP-seq
MIRT2549128	hsa-miR-4678	CLIP-seq
MIRT2549129	hsa-miR-4690-3p	CLIP-seq
MIRT2549130	hsa-miR-4695-5p	CLIP-seq
MIRT2549131	hsa-miR-4697-5p	CLIP-seq
MIRT2549132	hsa-miR-4700-5p	CLIP-seq
MIRT2682583	hsa-miR-4708-5p	CLIP-seq
MIRT2549133	hsa-miR-4728-3p	CLIP-seq
MIRT2549134	hsa-miR-4731-3p	CLIP-seq
MIRT2549135	hsa-miR-4748	CLIP-seq
MIRT2549136	hsa-miR-4772-5p	CLIP-seq
MIRT2549137	hsa-miR-4794	CLIP-seq
MIRT2549138	hsa-miR-4799-5p	CLIP-seq
MIRT2549139	hsa-miR-4801	CLIP-seq
MIRT2682584	hsa-miR-491-5p	CLIP-seq
MIRT2246014	hsa-miR-494	CLIP-seq
MIRT2246015	hsa-miR-497	CLIP-seq
MIRT2246016	hsa-miR-507	CLIP-seq
MIRT2013847	hsa-miR-511	CLIP-seq
MIRT2682585	hsa-miR-512-5p	CLIP-seq
MIRT2549140	hsa-miR-513c	CLIP-seq
MIRT2549141	hsa-miR-514b-5p	CLIP-seq
MIRT2549142	hsa-miR-518a-5p	CLIP-seq
MIRT2549143	hsa-miR-520d-5p	CLIP-seq
MIRT2549144	hsa-miR-524-5p	CLIP-seq
MIRT2549145	hsa-miR-527	CLIP-seq
MIRT2682586	hsa-miR-544b	CLIP-seq
MIRT2549147	hsa-miR-548c-3p	CLIP-seq
MIRT2549148	hsa-miR-549	CLIP-seq
MIRT2246017	hsa-miR-557	CLIP-seq
MIRT2013848	hsa-miR-571	CLIP-seq
MIRT2549149	hsa-miR-605	CLIP-seq
MIRT2549150	hsa-miR-630	CLIP-seq
MIRT2549151	hsa-miR-631	CLIP-seq
MIRT2549152	hsa-miR-637	CLIP-seq
MIRT2246019	hsa-miR-646	CLIP-seq
MIRT2013851	hsa-miR-659	CLIP-seq
MIRT2549153	hsa-miR-758	CLIP-seq
MIRT2549154	hsa-miR-759	CLIP-seq
MIRT2013852	hsa-miR-9	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	28098230
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004449	Function	Isocitrate dehydrogenase (NAD+) activity	EXP	4336621, 14555658, 16737955, 17432878, 33349631
GO:0004449	Function	Isocitrate dehydrogenase (NAD+) activity	IBA
GO:0004449	Function	Isocitrate dehydrogenase (NAD+) activity	IDA	28098230
GO:0004449	Function	Isocitrate dehydrogenase (NAD+) activity	IEA
GO:0005515	Function	Protein binding	IPI	14555658, 28098230, 28514442, 30613765, 31515270, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	14555658
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005975	Process	Carbohydrate metabolic process	NAS	8833160
GO:0006099	Process	Tricarboxylic acid cycle	IBA
GO:0006099	Process	Tricarboxylic acid cycle	IDA	14555658
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	TAS
GO:0006102	Process	Isocitrate metabolic process	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0045242	Component	Isocitrate dehydrogenase complex (NAD+)	IDA	14555658
GO:0045242	Component	Isocitrate dehydrogenase complex (NAD+)	IPI	14555658
GO:0046872	Function	Metal ion binding	IEA
GO:0051287	Function	NAD binding	IEA

MIM	HGNC	e!Ensembl
601149	5384	ENSG00000166411

P50213

Protein name

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)

Protein function

Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma

PDB

5GRE , 5GRF , 5GRH , 5GRI , 5GRL , 5YVT , 6KDE , 6KDF , 6KDY , 6KE3 , 6L57 , 6L59 , 7CE3 , 8GRB , 8GRD , 8GRG , 8GRH , 8GRU , 8GS5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00180	Iso_dh	33 → 358	Isocitrate/isopropylmalate dehydrogenase	Domain

Sequence

MAGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAP
IQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDL
YANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIA
EFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMV
QDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKD
MANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICR
RVKDLD

Sequence length

366

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Ovarian serous cystadenocarcinoma	Likely pathogenic	rs767257701	RCV005934643	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Retinitis pigmentosa 90	Pathogenic	rs2074707744, rs2074682724, rs765473830, rs2074683444, rs770798851, rs2074705330	RCV001255143 RCV001255144 RCV001255145 RCV001255146 RCV001255147 RCV001255148 View all (1 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
IDH3A-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinal dystrophy	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinitis pigmentosa	Conflicting classifications of pathogenicity	ClinVar Disgenet, Orphanet Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
RETINITIS PIGMENTOSA 1	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (34)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31355526		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	26782057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	29486777	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Conductive hearing loss	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of penis	Congenital Hypoplasia Of Penis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	CTD_human_DG	18784066		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Encephalopathies	Epileptic encephalopathy	BEFREE	28058510		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	29847670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma, Primary Open Angle	Glaucoma	BEFREE	29847670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypogonadism	Hypogonadism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Leber Congenital Amaurosis	Leber congenital amaurosis	Pubtator	40244231	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	35463978	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	28412069, 40244231	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial encephalopathy	Mitochondrial encephalopathy	Pubtator	40244231	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31355526		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	28058510		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthrosis Deformans	Osteoarthrosis Deformans	CTD_human_DG	18784066		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	BEFREE	28412069		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Retinitis Pigmentosa	Retinitis Pigmentosa	ORPHANET_DG	28412069		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Retinitis Pigmentosa	Retinitis pigmentosa	Pubtator	28412069, 40119724, 40244231	Associate	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Retinitis pigmentosa	Retinitis Pigmentosa	Orphanet			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Retinitis Pigmentosa	Retinitis Pigmentosa	GENOMICS_ENGLAND_DG	30478029		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	29486777	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vision Disorders	Visual disorder	Pubtator	28412069	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha)