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Gene Gene information from NCBI Gene database.
Entrez ID 23463
Gene name Isoprenylcysteine carboxyl methyltransferase
Gene symbol ICMT
Synonyms (NCBI Gene)
HSTE14MST098MSTP098PCCMTPCMTPPMT
Chromosome 1
Chromosome location 1p36.31
Summary This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative spl
miRNA miRNA information provided by mirtarbase database.
894 Show/Hide all (894)
miRTarBase ID miRNA Experiments Reference
MIRT020175 hsa-miR-130b-3p Sequencing 20371350
MIRT022702 hsa-miR-124-3p Microarray 18668037
MIRT028069 hsa-miR-93-5p Sequencing 20371350
MIRT029560 hsa-miR-26b-5p Sequencing 20371350
MIRT043333 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0003880 Function Protein C-terminal carboxyl O-methyltransferase activity TAS 9614111
GO:0004671 Function Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IBA
GO:0004671 Function Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IDA 9614111, 29051265
GO:0004671 Function Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605851 5350 ENSG00000116237
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60725
Protein name Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)
Protein function Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04140 ICMT 163 → 257 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. {ECO:0000269|PubMed:10649571}.
Sequence
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIH
FFGEEYLEYKKRVPTGLPFIKGVKVDL
Sequence length 284
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Terpenoid backbone biosynthesis Gamma carboxylation, hypusine formation and arylsulfatase activation