HTRA3 (HtrA serine peptidase 3)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 94031
• Gene name: HtrA serine peptidase 3
• Gene symbol: HTRA3
• Synonyms (NCBI Gene): Prsp, Tasp
• Chromosome: 4
• Chromosome location: 4p16.1

miRNA Show/Hide all (95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018144	hsa-miR-335-5p	Microarray	18185580
MIRT022741	hsa-miR-124-3p	Microarray	18668037
MIRT1057372	hsa-miR-3164	CLIP-seq
MIRT1057373	hsa-miR-3652	CLIP-seq
MIRT1057374	hsa-miR-4430	CLIP-seq
MIRT1057375	hsa-miR-4492	CLIP-seq
MIRT1057376	hsa-miR-4498	CLIP-seq
MIRT1057377	hsa-miR-4660	CLIP-seq
MIRT1057378	hsa-miR-711	CLIP-seq
MIRT1057379	hsa-miR-762	CLIP-seq
MIRT1057380	hsa-miR-890	CLIP-seq
MIRT1549710	hsa-miR-146a	CLIP-seq
MIRT1549711	hsa-miR-146b-5p	CLIP-seq
MIRT1057372	hsa-miR-3164	CLIP-seq
MIRT1057380	hsa-miR-890	CLIP-seq
MIRT1057372	hsa-miR-3164	CLIP-seq
MIRT1057380	hsa-miR-890	CLIP-seq
MIRT2245391	hsa-miR-1184	CLIP-seq
MIRT2245392	hsa-miR-1205	CLIP-seq
MIRT2245393	hsa-miR-2467-3p	CLIP-seq
MIRT2245394	hsa-miR-3158-5p	CLIP-seq
MIRT2245395	hsa-miR-320e	CLIP-seq
MIRT2245396	hsa-miR-3909	CLIP-seq
MIRT2245397	hsa-miR-4436b-3p	CLIP-seq
MIRT2245398	hsa-miR-4731-5p	CLIP-seq
MIRT2245399	hsa-miR-4761-3p	CLIP-seq
MIRT1057372	hsa-miR-3164	CLIP-seq
MIRT1057380	hsa-miR-890	CLIP-seq
MIRT2437665	hsa-miR-3194-3p	CLIP-seq
MIRT2437666	hsa-miR-4763-5p	CLIP-seq
MIRT2451479	hsa-miR-101	CLIP-seq
MIRT2451480	hsa-miR-141	CLIP-seq
MIRT2451481	hsa-miR-144	CLIP-seq
MIRT2451482	hsa-miR-200a	CLIP-seq
MIRT2451483	hsa-miR-4646-5p	CLIP-seq
MIRT2451479	hsa-miR-101	CLIP-seq
MIRT2451480	hsa-miR-141	CLIP-seq
MIRT2451481	hsa-miR-144	CLIP-seq
MIRT2451482	hsa-miR-200a	CLIP-seq
MIRT2451483	hsa-miR-4646-5p	CLIP-seq
MIRT2245391	hsa-miR-1184	CLIP-seq
MIRT2245392	hsa-miR-1205	CLIP-seq
MIRT2548636	hsa-miR-1228	CLIP-seq
MIRT2548637	hsa-miR-1913	CLIP-seq
MIRT2548638	hsa-miR-2110	CLIP-seq
MIRT2548639	hsa-miR-2355-5p	CLIP-seq
MIRT2548640	hsa-miR-3150a-3p	CLIP-seq
MIRT2245394	hsa-miR-3158-5p	CLIP-seq
MIRT2548641	hsa-miR-3189-3p	CLIP-seq
MIRT2548642	hsa-miR-3189-5p	CLIP-seq
MIRT2548643	hsa-miR-324-3p	CLIP-seq
MIRT2245396	hsa-miR-3909	CLIP-seq
MIRT1057377	hsa-miR-4660	CLIP-seq
MIRT2548644	hsa-miR-4758-3p	CLIP-seq
MIRT2245391	hsa-miR-1184	CLIP-seq
MIRT2245392	hsa-miR-1205	CLIP-seq
MIRT2548636	hsa-miR-1228	CLIP-seq
MIRT2682511	hsa-miR-1470	CLIP-seq
MIRT2682512	hsa-miR-1587	CLIP-seq
MIRT2548637	hsa-miR-1913	CLIP-seq
MIRT2548638	hsa-miR-2110	CLIP-seq
MIRT2548639	hsa-miR-2355-5p	CLIP-seq
MIRT2682513	hsa-miR-3147	CLIP-seq
MIRT2548640	hsa-miR-3150a-3p	CLIP-seq
MIRT2682514	hsa-miR-3150b-3p	CLIP-seq
MIRT2245394	hsa-miR-3158-5p	CLIP-seq
MIRT2682515	hsa-miR-3175	CLIP-seq
MIRT2548641	hsa-miR-3189-3p	CLIP-seq
MIRT2548642	hsa-miR-3189-5p	CLIP-seq
MIRT2548643	hsa-miR-324-3p	CLIP-seq
MIRT2682516	hsa-miR-3691-5p	CLIP-seq
MIRT2682517	hsa-miR-3692	CLIP-seq
MIRT2245396	hsa-miR-3909	CLIP-seq
MIRT2682518	hsa-miR-4425	CLIP-seq
MIRT2682519	hsa-miR-4434	CLIP-seq
MIRT2682520	hsa-miR-4491	CLIP-seq
MIRT2682521	hsa-miR-4514	CLIP-seq
MIRT2682522	hsa-miR-4516	CLIP-seq
MIRT2682523	hsa-miR-4645-5p	CLIP-seq
MIRT2682524	hsa-miR-4657	CLIP-seq
MIRT1057377	hsa-miR-4660	CLIP-seq
MIRT2682525	hsa-miR-4667-3p	CLIP-seq
MIRT2682526	hsa-miR-4673	CLIP-seq
MIRT2682527	hsa-miR-4674	CLIP-seq
MIRT2682528	hsa-miR-4692	CLIP-seq
MIRT2682529	hsa-miR-4707-5p	CLIP-seq
MIRT2682530	hsa-miR-4752	CLIP-seq
MIRT2548644	hsa-miR-4758-3p	CLIP-seq
MIRT2682531	hsa-miR-4764-5p	CLIP-seq
MIRT2682532	hsa-miR-4781-3p	CLIP-seq
MIRT2682533	hsa-miR-4784	CLIP-seq
MIRT2682534	hsa-miR-624	CLIP-seq
MIRT2682535	hsa-miR-642a	CLIP-seq
MIRT2682536	hsa-miR-765	CLIP-seq
MIRT2682537	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IDA	18387192
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	22229724, 25002585, 26110759, 28642151, 29477555, 31260151, 31470122, 31899476
GO:0005576	Component	Extracellular region	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IDA	18387192, 22229724
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IDA	22229724
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0030514	Process	Negative regulation of BMP signaling pathway	IEA
GO:0030514	Process	Negative regulation of BMP signaling pathway	ISS
GO:0042802	Function	Identical protein binding	IPI	26110759, 28642151, 31899476

Other IDs

• MIM: 608785
• HGNC: 30406
• e!Ensembl: ENSG00000170801

Protein

• UniProt ID: P83110
• Protein name: Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)
• Protein function: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degra
• PDB: 2P3W , 4RI0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00219	IGFBP	25 → 76	Insulin-like growth factor binding protein	Domain
  PF07648	Kazal_2	76 → 126	Kazal-type serine protease inhibitor domain	Domain
  PF13365	Trypsin_2	175 → 319		Domain
  PF17820	PDZ_6	387 → 438	PDZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart
• Sequence:

  MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
  PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
  LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
  SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
  VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
  NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
  MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
  ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

• Sequence length: 453

Related Genes

No strongly related genes found yet for HTRA3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HTRA3.