HTATSF1 (HIV-1 Tat specific factor 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27336
• Gene name: HIV-1 Tat specific factor 1
• Gene symbol: HTATSF1
• Synonyms (NCBI Gene): TAT-SF1, TATSF1, dJ196E23.2
• Chromosome: X
• Chromosome location: Xq26.3
• Summary: The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcr

miRNA Show/Hide all (41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT036920	hsa-miR-877-3p	CLASH	23622248
MIRT1057131	hsa-miR-10a	CLIP-seq
MIRT1057132	hsa-miR-10b	CLIP-seq
MIRT1057133	hsa-miR-145	CLIP-seq
MIRT1057134	hsa-miR-3133	CLIP-seq
MIRT1057135	hsa-miR-4742-5p	CLIP-seq
MIRT1057133	hsa-miR-145	CLIP-seq
MIRT2013043	hsa-miR-3129-3p	CLIP-seq
MIRT2013044	hsa-miR-331-5p	CLIP-seq
MIRT2013045	hsa-miR-33a	CLIP-seq
MIRT2013046	hsa-miR-33b	CLIP-seq
MIRT2013047	hsa-miR-425	CLIP-seq
MIRT2013048	hsa-miR-4275	CLIP-seq
MIRT2013049	hsa-miR-4502	CLIP-seq
MIRT2013050	hsa-miR-4642	CLIP-seq
MIRT2013051	hsa-miR-494	CLIP-seq
MIRT2013052	hsa-miR-552	CLIP-seq
MIRT2013051	hsa-miR-494	CLIP-seq
MIRT1057133	hsa-miR-145	CLIP-seq
MIRT2013043	hsa-miR-3129-3p	CLIP-seq
MIRT1057134	hsa-miR-3133	CLIP-seq
MIRT2548578	hsa-miR-3143	CLIP-seq
MIRT2013045	hsa-miR-33a	CLIP-seq
MIRT2013046	hsa-miR-33b	CLIP-seq
MIRT2013047	hsa-miR-425	CLIP-seq
MIRT2013048	hsa-miR-4275	CLIP-seq
MIRT2548579	hsa-miR-4803	CLIP-seq
MIRT2548580	hsa-miR-548aa	CLIP-seq
MIRT1057133	hsa-miR-145	CLIP-seq
MIRT2013043	hsa-miR-3129-3p	CLIP-seq
MIRT1057134	hsa-miR-3133	CLIP-seq
MIRT2548578	hsa-miR-3143	CLIP-seq
MIRT2013044	hsa-miR-331-5p	CLIP-seq
MIRT2013045	hsa-miR-33a	CLIP-seq
MIRT2013046	hsa-miR-33b	CLIP-seq
MIRT2013047	hsa-miR-425	CLIP-seq
MIRT2013048	hsa-miR-4275	CLIP-seq
MIRT2548579	hsa-miR-4803	CLIP-seq
MIRT2013051	hsa-miR-494	CLIP-seq
MIRT2548580	hsa-miR-548aa	CLIP-seq
MIRT2013052	hsa-miR-552	CLIP-seq

Gene ontology (GO) Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	32494006, 34822310, 36797247
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	31744343
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	18417535, 26811421
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	35597237
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 30567737, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	31744343
GO:0005634	Component	Nucleus	TAS	10454543
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005684	Component	U2-type spliceosomal complex	IBA
GO:0005684	Component	U2-type spliceosomal complex	IDA	32494006, 34822310, 36797247
GO:0005684	Component	U2-type spliceosomal complex	IEA
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	NAS	31744343
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0035861	Component	Site of double-strand break	IDA	35597237
GO:0140463	Function	Chromatin-protein adaptor activity	IDA	35597237
GO:0160004	Function	Poly-ADP-D-ribose modification-dependent protein binding	IDA	35597237
GO:1903241	Process	U2-type prespliceosome assembly	IDA	32494006, 34822310
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343
GO:1990166	Process	Protein localization to site of double-strand break	IDA	35597237

Other IDs

• MIM: 300346
• HGNC: 5276
• e!Ensembl: ENSG00000102241

Protein

• UniProt ID: O43719
• Protein name: 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1)
• Protein function: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates i
• PDB: 2DIT , 6N3D , 6N3E , 6N3F , 6NSX , 6Y50 , 6Y53 , 6Y5Q , 7EVO , 7Q3L , 8HK1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	287 → 343	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	135 → 212	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8849451}.
• Sequence:

  MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF
  PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA
  ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL
  KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL
  SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ
  IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR
  EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM
  AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC
  SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE
  EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS
  EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD
  KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD
  SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI

• Sequence length: 755

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
HTATSF1-related disorder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	34344401	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	28720891	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for HTATSF1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HTATSF1.