HSPBP1 (HSPA (Hsp70) binding protein 1)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23640
• Gene name: HSPA (Hsp70) binding protein 1
• Gene symbol: HSPBP1
• Synonyms (NCBI Gene): FES1
• Chromosome: 19
• Chromosome location: 19q13.42

miRNA Show/Hide all (112)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025683	hsa-miR-7-5p	Microarray	19073608
MIRT031614	hsa-miR-16-5p	Proteomics	18668040
MIRT049498	hsa-miR-92a-3p	CLASH	23622248
MIRT046019	hsa-miR-125b-5p	CLASH	23622248
MIRT042390	hsa-miR-484	CLASH	23622248
MIRT1056617	hsa-miR-1255a	CLIP-seq
MIRT1056618	hsa-miR-1255b	CLIP-seq
MIRT1056619	hsa-miR-138	CLIP-seq
MIRT1056620	hsa-miR-147	CLIP-seq
MIRT1056621	hsa-miR-28-5p	CLIP-seq
MIRT1056622	hsa-miR-3138	CLIP-seq
MIRT1056623	hsa-miR-3139	CLIP-seq
MIRT1056624	hsa-miR-3911	CLIP-seq
MIRT1056625	hsa-miR-3925-5p	CLIP-seq
MIRT1056626	hsa-miR-4487	CLIP-seq
MIRT1056627	hsa-miR-4693-3p	CLIP-seq
MIRT1056628	hsa-miR-4712-3p	CLIP-seq
MIRT1056629	hsa-miR-4800-5p	CLIP-seq
MIRT1056630	hsa-miR-542-5p	CLIP-seq
MIRT1056631	hsa-miR-548q	CLIP-seq
MIRT1056632	hsa-miR-615-5p	CLIP-seq
MIRT1056633	hsa-miR-644	CLIP-seq
MIRT1056634	hsa-miR-7	CLIP-seq
MIRT1056635	hsa-miR-708	CLIP-seq
MIRT2012981	hsa-miR-4747-3p	CLIP-seq
MIRT2245259	hsa-miR-188-5p	CLIP-seq
MIRT2245260	hsa-miR-3189-3p	CLIP-seq
MIRT2245261	hsa-miR-3689a-3p	CLIP-seq
MIRT2245262	hsa-miR-3689c	CLIP-seq
MIRT2245263	hsa-miR-4312	CLIP-seq
MIRT2245264	hsa-miR-4512	CLIP-seq
MIRT2245265	hsa-miR-4780	CLIP-seq
MIRT2245266	hsa-miR-623	CLIP-seq
MIRT2451449	hsa-miR-143	CLIP-seq
MIRT2451450	hsa-miR-4428	CLIP-seq
MIRT2451451	hsa-miR-4770	CLIP-seq
MIRT2548431	hsa-miR-1260	CLIP-seq
MIRT2548432	hsa-miR-1260b	CLIP-seq
MIRT2548433	hsa-miR-1291	CLIP-seq
MIRT2548434	hsa-miR-1321	CLIP-seq
MIRT2548435	hsa-miR-188-3p	CLIP-seq
MIRT2245259	hsa-miR-188-5p	CLIP-seq
MIRT2548436	hsa-miR-31	CLIP-seq
MIRT2548437	hsa-miR-3150a-3p	CLIP-seq
MIRT2548438	hsa-miR-3154	CLIP-seq
MIRT2548439	hsa-miR-3156-3p	CLIP-seq
MIRT2548440	hsa-miR-3170	CLIP-seq
MIRT2548441	hsa-miR-3173-5p	CLIP-seq
MIRT2548442	hsa-miR-3175	CLIP-seq
MIRT2548443	hsa-miR-3179	CLIP-seq
MIRT2245260	hsa-miR-3189-3p	CLIP-seq
MIRT2548444	hsa-miR-3612	CLIP-seq
MIRT2548445	hsa-miR-3620	CLIP-seq
MIRT2245261	hsa-miR-3689a-3p	CLIP-seq
MIRT2245262	hsa-miR-3689c	CLIP-seq
MIRT2548446	hsa-miR-4269	CLIP-seq
MIRT2548447	hsa-miR-4292	CLIP-seq
MIRT2245263	hsa-miR-4312	CLIP-seq
MIRT2548448	hsa-miR-4419a	CLIP-seq
MIRT2548449	hsa-miR-4434	CLIP-seq
MIRT2548450	hsa-miR-4510	CLIP-seq
MIRT2245264	hsa-miR-4512	CLIP-seq
MIRT2548451	hsa-miR-4516	CLIP-seq
MIRT2548452	hsa-miR-4645-5p	CLIP-seq
MIRT2548453	hsa-miR-4673	CLIP-seq
MIRT2548454	hsa-miR-4728-5p	CLIP-seq
MIRT2548455	hsa-miR-4739	CLIP-seq
MIRT2012981	hsa-miR-4747-3p	CLIP-seq
MIRT2548456	hsa-miR-4756-5p	CLIP-seq
MIRT2245265	hsa-miR-4780	CLIP-seq
MIRT2548457	hsa-miR-491-5p	CLIP-seq
MIRT2245266	hsa-miR-623	CLIP-seq
MIRT2548458	hsa-miR-650	CLIP-seq
MIRT2548459	hsa-miR-661	CLIP-seq
MIRT2548460	hsa-miR-662	CLIP-seq
MIRT2548461	hsa-miR-939	CLIP-seq
MIRT2548431	hsa-miR-1260	CLIP-seq
MIRT2548432	hsa-miR-1260b	CLIP-seq
MIRT2548433	hsa-miR-1291	CLIP-seq
MIRT2548434	hsa-miR-1321	CLIP-seq
MIRT2548435	hsa-miR-188-3p	CLIP-seq
MIRT2245259	hsa-miR-188-5p	CLIP-seq
MIRT2548436	hsa-miR-31	CLIP-seq
MIRT2548437	hsa-miR-3150a-3p	CLIP-seq
MIRT2548439	hsa-miR-3156-3p	CLIP-seq
MIRT2548440	hsa-miR-3170	CLIP-seq
MIRT2548441	hsa-miR-3173-5p	CLIP-seq
MIRT2548442	hsa-miR-3175	CLIP-seq
MIRT2245260	hsa-miR-3189-3p	CLIP-seq
MIRT2548444	hsa-miR-3612	CLIP-seq
MIRT2548445	hsa-miR-3620	CLIP-seq
MIRT2245261	hsa-miR-3689a-3p	CLIP-seq
MIRT2245262	hsa-miR-3689c	CLIP-seq
MIRT2548446	hsa-miR-4269	CLIP-seq
MIRT2548447	hsa-miR-4292	CLIP-seq
MIRT2245263	hsa-miR-4312	CLIP-seq
MIRT2548448	hsa-miR-4419a	CLIP-seq
MIRT2548450	hsa-miR-4510	CLIP-seq
MIRT2245264	hsa-miR-4512	CLIP-seq
MIRT2548452	hsa-miR-4645-5p	CLIP-seq
MIRT2548453	hsa-miR-4673	CLIP-seq
MIRT2548454	hsa-miR-4728-5p	CLIP-seq
MIRT2548455	hsa-miR-4739	CLIP-seq
MIRT2012981	hsa-miR-4747-3p	CLIP-seq
MIRT2548456	hsa-miR-4756-5p	CLIP-seq
MIRT2245265	hsa-miR-4780	CLIP-seq
MIRT2548457	hsa-miR-491-5p	CLIP-seq
MIRT2245266	hsa-miR-623	CLIP-seq
MIRT2548458	hsa-miR-650	CLIP-seq
MIRT2548459	hsa-miR-661	CLIP-seq
MIRT2548460	hsa-miR-662	CLIP-seq
MIRT2548461	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IBA
GO:0004857	Function	Enzyme inhibitor activity	TAS	9830037
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 16713569, 25416956, 28514442, 29568061, 31515488, 33961781, 35271311
GO:0005615	Component	Extracellular space	IDA	16827227
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0006457	Process	Protein folding	TAS	9830037
GO:0031398	Process	Positive regulation of protein ubiquitination	IDA	16831871
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	16207813
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	16831871
GO:0140313	Function	Molecular sequestering activity	IDA	21247889

Other IDs

• MIM: 612939
• HGNC: 24989
• e!Ensembl: ENSG00000133265

Protein

• UniProt ID: Q9NZL4
• Protein name: Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)
• Protein function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
• PDB: 1XQR , 1XQS , 8X87
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08609	Fes1	45 → 140	Nucleotide exchange factor Fes1	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9830037}.
• Sequence:

  MSDEGSRGSRLPLALPPASQGCSSGGGGGGSSAGGSGNSRPPRNLQGLLQMAITAGSEEP
  DPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQPMPPTAGEAEQAADQQER
  EGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQ
  EQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQ
  QQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVRTEHSPFHEHVLGALCSLV
  TDFPQGVRECREPELGLEELLRHRCQLLQQHEEYQEELEFCEKLLQTCFSSPADDSMDR

• Sequence length: 359

Pathways

KEGG Pathway:

Protein processing in endoplasmic reticulum

Related Genes

No strongly related genes found yet for HSPBP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HSPBP1.