HSPA12B (heat shock protein family A (Hsp70) member 12B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 116835
• Gene name: Heat shock protein family A (Hsp70) member 12B
• Gene symbol: HSPA12B
• Synonyms (NCBI Gene): C20orf60
• Chromosome: 20
• Chromosome location: 20p13
• Summary: The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results

miRNA Show/Hide all (71)

miRTarBase ID	miRNA	Experiments	Reference
MIRT616052	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT616051	hsa-miR-4496	HITS-CLIP	23824327
MIRT616050	hsa-miR-9500	HITS-CLIP	23824327
MIRT616049	hsa-miR-33b-3p	HITS-CLIP	23824327
MIRT616048	hsa-miR-515-3p	HITS-CLIP	23824327
MIRT616047	hsa-miR-519e-3p	HITS-CLIP	23824327
MIRT616046	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT616045	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT616044	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT616043	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT616042	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT616041	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT616040	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT616039	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT616038	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT616052	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT616051	hsa-miR-4496	HITS-CLIP	23824327
MIRT616050	hsa-miR-9500	HITS-CLIP	23824327
MIRT616049	hsa-miR-33b-3p	HITS-CLIP	23824327
MIRT616048	hsa-miR-515-3p	HITS-CLIP	23824327
MIRT616047	hsa-miR-519e-3p	HITS-CLIP	23824327
MIRT616046	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT616045	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT616044	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT616043	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT616042	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT616041	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT616040	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT616039	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT616038	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056007	hsa-miR-1539	CLIP-seq
MIRT1056008	hsa-miR-1976	CLIP-seq
MIRT1056009	hsa-miR-3193	CLIP-seq
MIRT1056010	hsa-miR-3667-3p	CLIP-seq
MIRT1056011	hsa-miR-4691-5p	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT2245176	hsa-miR-1289	CLIP-seq
MIRT1056007	hsa-miR-1539	CLIP-seq
MIRT1056009	hsa-miR-3193	CLIP-seq
MIRT2245177	hsa-miR-3198	CLIP-seq
MIRT2245178	hsa-miR-4294	CLIP-seq
MIRT2245179	hsa-miR-4309	CLIP-seq
MIRT2245180	hsa-miR-4436b-5p	CLIP-seq
MIRT2245181	hsa-miR-516b	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT2245182	hsa-miR-642a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT2682468	hsa-miR-3176	CLIP-seq
MIRT2682469	hsa-miR-3922-3p	CLIP-seq
MIRT2682470	hsa-miR-4317	CLIP-seq
MIRT2682471	hsa-miR-4469	CLIP-seq
MIRT2682472	hsa-miR-4757-5p	CLIP-seq
MIRT2245182	hsa-miR-642a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0043542	Process	Endothelial cell migration	IEA

Other IDs

• MIM: 610702
• HGNC: 16193
• e!Ensembl: ENSG00000132622

Protein

• UniProt ID: Q96MM6
• Protein name: Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)
• Tissue specificity: TISSUE SPECIFICITY: Highest expression in muscle and heart. Lower levels in liver and kidney. {ECO:0000269|PubMed:12552099}.
• Sequence:

  MLAVPEMGLQGLYIGSSPERSPVPSPPGSPRTQESCGIAPLTPSQSPKPEVRAPQQASFS
  VVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGY
  TARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHALRFF
  REHALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIA
  LEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVE
  SGVGELWAEMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAF
  EQLLCRIFGEDFIATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRK
  QRGHNVETALRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALLARPEVQGV
  KLLFLVGGFAESAVLQHAVQAALGARGLRVVVPHDVGLTILKGAVLFGQAPGVVRVRRSP
  LTYGVGVLNRFVPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPG
  QRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFG
  DTEIKVTAVDVSTNRSVRASIDFLSN

• Sequence length: 686

Pathways

Reactome Pathway:

Regulation of HSF1-mediated heat shock response

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
PULMONARY EDEMA	—	CTD	38901789	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	38162683	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (14)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	BEFREE	23331525		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	27387956	Associate	★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	29556279		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29954368	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	25909170, 30195756		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29411514		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	37033211	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	23046810, 29411514		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	25909170		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	25909170, 30195756		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	28281242		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29556279		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29556279		★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	20733008, 28535510		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for HSPA12B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HSPA12B.