HSH2D (hematopoietic SH2 domain containing)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 84941
• Gene name: Hematopoietic SH2 domain containing
• Gene symbol: HSH2D
• Synonyms (NCBI Gene): ALX, HSH2
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et

miRNA Show/Hide all (109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018770	hsa-miR-335-5p	Microarray	18185580
MIRT1055749	hsa-miR-1225-3p	CLIP-seq
MIRT1055750	hsa-miR-1233	CLIP-seq
MIRT1055751	hsa-miR-197	CLIP-seq
MIRT1055752	hsa-miR-3155	CLIP-seq
MIRT1055753	hsa-miR-3155b	CLIP-seq
MIRT1055754	hsa-miR-3187-3p	CLIP-seq
MIRT1055755	hsa-miR-3663-5p	CLIP-seq
MIRT1055756	hsa-miR-3940-3p	CLIP-seq
MIRT1055757	hsa-miR-4252	CLIP-seq
MIRT1055758	hsa-miR-4258	CLIP-seq
MIRT1055759	hsa-miR-4435	CLIP-seq
MIRT1055760	hsa-miR-4438	CLIP-seq
MIRT1055761	hsa-miR-4532	CLIP-seq
MIRT1055762	hsa-miR-4701-5p	CLIP-seq
MIRT1055763	hsa-miR-4713-5p	CLIP-seq
MIRT1055764	hsa-miR-4716-5p	CLIP-seq
MIRT1055765	hsa-miR-4755-3p	CLIP-seq
MIRT1055766	hsa-miR-4781-3p	CLIP-seq
MIRT1055767	hsa-miR-483-5p	CLIP-seq
MIRT1055768	hsa-miR-484	CLIP-seq
MIRT1055769	hsa-miR-498	CLIP-seq
MIRT1055770	hsa-miR-5095	CLIP-seq
MIRT1055771	hsa-miR-5096	CLIP-seq
MIRT1055772	hsa-miR-548s	CLIP-seq
MIRT1055773	hsa-miR-588	CLIP-seq
MIRT2012793	hsa-miR-150	CLIP-seq
MIRT2012794	hsa-miR-3128	CLIP-seq
MIRT1055752	hsa-miR-3155	CLIP-seq
MIRT1055753	hsa-miR-3155b	CLIP-seq
MIRT2012795	hsa-miR-3171	CLIP-seq
MIRT2012796	hsa-miR-3652	CLIP-seq
MIRT2012797	hsa-miR-378	CLIP-seq
MIRT2012798	hsa-miR-378b	CLIP-seq
MIRT2012799	hsa-miR-378c	CLIP-seq
MIRT2012800	hsa-miR-378d	CLIP-seq
MIRT2012801	hsa-miR-378e	CLIP-seq
MIRT2012802	hsa-miR-378f	CLIP-seq
MIRT2012803	hsa-miR-378h	CLIP-seq
MIRT2012804	hsa-miR-378i	CLIP-seq
MIRT2012805	hsa-miR-422a	CLIP-seq
MIRT2012806	hsa-miR-4283	CLIP-seq
MIRT2012807	hsa-miR-4430	CLIP-seq
MIRT1055760	hsa-miR-4438	CLIP-seq
MIRT2012808	hsa-miR-4489	CLIP-seq
MIRT1055761	hsa-miR-4532	CLIP-seq
MIRT2012809	hsa-miR-4639-3p	CLIP-seq
MIRT2012810	hsa-miR-4645-5p	CLIP-seq
MIRT2012811	hsa-miR-4656	CLIP-seq
MIRT2012812	hsa-miR-4673	CLIP-seq
MIRT2012813	hsa-miR-4720-5p	CLIP-seq
MIRT2012814	hsa-miR-4799-3p	CLIP-seq
MIRT1055768	hsa-miR-484	CLIP-seq
MIRT1055770	hsa-miR-5095	CLIP-seq
MIRT2012815	hsa-miR-562	CLIP-seq
MIRT2245136	hsa-miR-1262	CLIP-seq
MIRT2245137	hsa-miR-1269	CLIP-seq
MIRT2245138	hsa-miR-1269b	CLIP-seq
MIRT2245139	hsa-miR-1286	CLIP-seq
MIRT2245140	hsa-miR-1288	CLIP-seq
MIRT1055751	hsa-miR-197	CLIP-seq
MIRT2012796	hsa-miR-3652	CLIP-seq
MIRT1055755	hsa-miR-3663-5p	CLIP-seq
MIRT2012797	hsa-miR-378	CLIP-seq
MIRT2012798	hsa-miR-378b	CLIP-seq
MIRT2012799	hsa-miR-378c	CLIP-seq
MIRT2012800	hsa-miR-378d	CLIP-seq
MIRT2012801	hsa-miR-378e	CLIP-seq
MIRT2012802	hsa-miR-378f	CLIP-seq
MIRT2012803	hsa-miR-378h	CLIP-seq
MIRT2012804	hsa-miR-378i	CLIP-seq
MIRT2012805	hsa-miR-422a	CLIP-seq
MIRT2245141	hsa-miR-4418	CLIP-seq
MIRT2012807	hsa-miR-4430	CLIP-seq
MIRT2245142	hsa-miR-4515	CLIP-seq
MIRT2012810	hsa-miR-4645-5p	CLIP-seq
MIRT2012812	hsa-miR-4673	CLIP-seq
MIRT2245143	hsa-miR-4701-3p	CLIP-seq
MIRT1055764	hsa-miR-4716-5p	CLIP-seq
MIRT2245144	hsa-miR-4722-5p	CLIP-seq
MIRT2245145	hsa-miR-4740-5p	CLIP-seq
MIRT1055765	hsa-miR-4755-3p	CLIP-seq
MIRT1055766	hsa-miR-4781-3p	CLIP-seq
MIRT2245146	hsa-miR-4787-3p	CLIP-seq
MIRT2245147	hsa-miR-509-3-5p	CLIP-seq
MIRT2245148	hsa-miR-509-5p	CLIP-seq
MIRT1055771	hsa-miR-5096	CLIP-seq
MIRT2245149	hsa-miR-873	CLIP-seq
MIRT2245137	hsa-miR-1269	CLIP-seq
MIRT2245138	hsa-miR-1269b	CLIP-seq
MIRT2245140	hsa-miR-1288	CLIP-seq
MIRT2012796	hsa-miR-3652	CLIP-seq
MIRT2012797	hsa-miR-378	CLIP-seq
MIRT2012798	hsa-miR-378b	CLIP-seq
MIRT2012799	hsa-miR-378c	CLIP-seq
MIRT2012800	hsa-miR-378d	CLIP-seq
MIRT2012801	hsa-miR-378e	CLIP-seq
MIRT2012802	hsa-miR-378f	CLIP-seq
MIRT2012803	hsa-miR-378h	CLIP-seq
MIRT2012804	hsa-miR-378i	CLIP-seq
MIRT2012805	hsa-miR-422a	CLIP-seq
MIRT2245141	hsa-miR-4418	CLIP-seq
MIRT2012807	hsa-miR-4430	CLIP-seq
MIRT2245142	hsa-miR-4515	CLIP-seq
MIRT2012810	hsa-miR-4645-5p	CLIP-seq
MIRT2012812	hsa-miR-4673	CLIP-seq
MIRT2245145	hsa-miR-4740-5p	CLIP-seq
MIRT2245147	hsa-miR-509-3-5p	CLIP-seq
MIRT2245148	hsa-miR-509-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002903	Process	Negative regulation of B cell apoptotic process	IEA
GO:0005515	Function	Protein binding	IPI	24728074, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0042110	Process	T cell activation	IEA
GO:0051902	Process	Negative regulation of mitochondrial depolarization	IEA

Other IDs

• MIM: 608349
• HGNC: 24920
• e!Ensembl: ENSG00000196684

Protein

• UniProt ID: Q96JZ2
• Protein name: Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
• Protein function: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of
• PDB: 2CS0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	34 → 109	SH2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. {ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172}.
• Sequence:

  MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRV
  SHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRREL
  LTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNR
  ITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRST
  VISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCI
  EVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC

• Sequence length: 352

Related Genes

No strongly related genes found yet for HSH2D.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HSH2D.