Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51478
Gene name	Hydroxysteroid 17-beta dehydrogenase 7
Gene symbol	HSD17B7
Synonyms (NCBI Gene)	PRAPSDR37C1
Chromosome	1
Chromosome location	1q23.3
Summary	HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018884	hsa-miR-335-5p	Microarray	18185580
MIRT020937	hsa-miR-155-5p	Proteomics	18668040
MIRT1055446	hsa-miR-105	CLIP-seq
MIRT1055447	hsa-miR-1182	CLIP-seq
MIRT1055448	hsa-miR-122	CLIP-seq
MIRT1055449	hsa-miR-1237	CLIP-seq
MIRT1055450	hsa-miR-1245	CLIP-seq
MIRT1055451	hsa-miR-1248	CLIP-seq
MIRT1055452	hsa-miR-199a-3p	CLIP-seq
MIRT1055453	hsa-miR-199b-3p	CLIP-seq
MIRT1055454	hsa-miR-216a	CLIP-seq
MIRT1055455	hsa-miR-3129-5p	CLIP-seq
MIRT1055456	hsa-miR-3135b	CLIP-seq
MIRT1055457	hsa-miR-3545-3p	CLIP-seq
MIRT1055458	hsa-miR-3652	CLIP-seq
MIRT1055459	hsa-miR-3663-5p	CLIP-seq
MIRT1055460	hsa-miR-4430	CLIP-seq
MIRT1055461	hsa-miR-448	CLIP-seq
MIRT1055462	hsa-miR-4635	CLIP-seq
MIRT1055463	hsa-miR-4680-5p	CLIP-seq
MIRT1055464	hsa-miR-4716-5p	CLIP-seq
MIRT1055465	hsa-miR-4772-3p	CLIP-seq
MIRT1055466	hsa-miR-4797-3p	CLIP-seq
MIRT1055467	hsa-miR-513c	CLIP-seq
MIRT1055468	hsa-miR-514b-5p	CLIP-seq
MIRT1055469	hsa-miR-520d-5p	CLIP-seq
MIRT1055470	hsa-miR-524-5p	CLIP-seq
MIRT1055471	hsa-miR-556-3p	CLIP-seq
MIRT1055472	hsa-miR-656	CLIP-seq
MIRT1055473	hsa-miR-720	CLIP-seq
MIRT1055474	hsa-miR-936	CLIP-seq
MIRT1055446	hsa-miR-105	CLIP-seq
MIRT1055448	hsa-miR-122	CLIP-seq
MIRT1055449	hsa-miR-1237	CLIP-seq
MIRT1055450	hsa-miR-1245	CLIP-seq
MIRT1055451	hsa-miR-1248	CLIP-seq
MIRT2012690	hsa-miR-1266	CLIP-seq
MIRT1055452	hsa-miR-199a-3p	CLIP-seq
MIRT1055453	hsa-miR-199b-3p	CLIP-seq
MIRT1055454	hsa-miR-216a	CLIP-seq
MIRT1055455	hsa-miR-3129-5p	CLIP-seq
MIRT1055456	hsa-miR-3135b	CLIP-seq
MIRT2012691	hsa-miR-3155	CLIP-seq
MIRT2012692	hsa-miR-3155b	CLIP-seq
MIRT1055457	hsa-miR-3545-3p	CLIP-seq
MIRT1055458	hsa-miR-3652	CLIP-seq
MIRT1055459	hsa-miR-3663-5p	CLIP-seq
MIRT2012693	hsa-miR-3664-3p	CLIP-seq
MIRT1055460	hsa-miR-4430	CLIP-seq
MIRT1055461	hsa-miR-448	CLIP-seq
MIRT2012694	hsa-miR-4518	CLIP-seq
MIRT1055462	hsa-miR-4635	CLIP-seq
MIRT1055463	hsa-miR-4680-5p	CLIP-seq
MIRT1055464	hsa-miR-4716-5p	CLIP-seq
MIRT1055465	hsa-miR-4772-3p	CLIP-seq
MIRT1055466	hsa-miR-4797-3p	CLIP-seq
MIRT2012695	hsa-miR-484	CLIP-seq
MIRT1055467	hsa-miR-513c	CLIP-seq
MIRT1055468	hsa-miR-514b-5p	CLIP-seq
MIRT1055469	hsa-miR-520d-5p	CLIP-seq
MIRT1055470	hsa-miR-524-5p	CLIP-seq
MIRT1055471	hsa-miR-556-3p	CLIP-seq
MIRT1055472	hsa-miR-656	CLIP-seq
MIRT1055473	hsa-miR-720	CLIP-seq
MIRT1055474	hsa-miR-936	CLIP-seq
MIRT1055448	hsa-miR-122	CLIP-seq
MIRT1055452	hsa-miR-199a-3p	CLIP-seq
MIRT1055453	hsa-miR-199b-3p	CLIP-seq
MIRT1055454	hsa-miR-216a	CLIP-seq
MIRT1055455	hsa-miR-3129-5p	CLIP-seq
MIRT1055456	hsa-miR-3135b	CLIP-seq
MIRT2245045	hsa-miR-3180-5p	CLIP-seq
MIRT1055458	hsa-miR-3652	CLIP-seq
MIRT1055460	hsa-miR-4430	CLIP-seq
MIRT1055464	hsa-miR-4716-5p	CLIP-seq
MIRT1055465	hsa-miR-4772-3p	CLIP-seq
MIRT1055466	hsa-miR-4797-3p	CLIP-seq
MIRT2245046	hsa-miR-520a-5p	CLIP-seq
MIRT2245047	hsa-miR-525-5p	CLIP-seq
MIRT2245048	hsa-miR-616	CLIP-seq
MIRT1055472	hsa-miR-656	CLIP-seq
MIRT1055473	hsa-miR-720	CLIP-seq
MIRT2245049	hsa-miR-759	CLIP-seq
MIRT1055474	hsa-miR-936	CLIP-seq
MIRT1055448	hsa-miR-122	CLIP-seq
MIRT1055454	hsa-miR-216a	CLIP-seq
MIRT1055456	hsa-miR-3135b	CLIP-seq
MIRT1055458	hsa-miR-3652	CLIP-seq
MIRT1055460	hsa-miR-4430	CLIP-seq
MIRT1055465	hsa-miR-4772-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000253	Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity	IBA
GO:0000253	Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity	IDA	12829805
GO:0000253	Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity	IEA
GO:0000253	Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity	TAS
GO:0004303	Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IBA
GO:0004303	Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA	12732193, 19772289
GO:0004303	Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IEA
GO:0004303	Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] activity	TAS	10544267
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	12829805
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006695	Process	Cholesterol biosynthetic process	IBA
GO:0006695	Process	Cholesterol biosynthetic process	IDA	12829805
GO:0006695	Process	Cholesterol biosynthetic process	IEA
GO:0006695	Process	Cholesterol biosynthetic process	TAS
GO:0006703	Process	Estrogen biosynthetic process	IDA	12732193
GO:0006703	Process	Estrogen biosynthetic process	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007420	Process	Brain development	IEA
GO:0008209	Process	Androgen metabolic process	IDA	12732193
GO:0008209	Process	Androgen metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0047024	Function	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity	IBA
GO:0047024	Function	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity	IDA	12732193, 19772289
GO:0047024	Function	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity	IEA
GO:0048568	Process	Embryonic organ development	IEA
GO:0048706	Process	Embryonic skeletal system development	IEA

MIM	HGNC	e!Ensembl
606756	5215	ENSG00000132196

P56937

Protein name

3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC

Protein function

Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:11165030, PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:19772289, PubMed:20659585). Catalyzes the NADP(H)-dependent reduction of estrogen

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00106	adh_short	3 → 235	short chain dehydrogenase	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues te

Sequence

MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA
EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS
LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW
TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL

Sequence length

341

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Steroid biosynthesis	Cholesterol biosynthesis
Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis

HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7)

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