Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	374875
Gene name	Hydroxysteroid 11-beta dehydrogenase 1 like
Gene symbol	HSD11B1L
Synonyms (NCBI Gene)	11-DH311-beta-HSD3HSD1LHSD3SCDR10SCDR10BSDR26C2
Chromosome	19
Chromosome location	19p13.3
Summary	This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding mul

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miRTarBase ID	miRNA	Experiments	Reference
MIRT715754	hsa-miR-4259	HITS-CLIP	19536157
MIRT715753	hsa-miR-571	HITS-CLIP	19536157
MIRT715752	hsa-miR-6795-5p	HITS-CLIP	19536157
MIRT715751	hsa-miR-6887-5p	HITS-CLIP	19536157
MIRT715750	hsa-miR-328-5p	HITS-CLIP	19536157
MIRT715749	hsa-miR-6885-5p	HITS-CLIP	19536157
MIRT715748	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT715747	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT715746	hsa-miR-4326	HITS-CLIP	19536157
MIRT715745	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT715744	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT715743	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT715742	hsa-miR-1275	HITS-CLIP	19536157
MIRT715741	hsa-miR-4665-5p	HITS-CLIP	19536157
MIRT715740	hsa-miR-7109-5p	HITS-CLIP	19536157
MIRT715739	hsa-miR-6751-5p	HITS-CLIP	19536157
MIRT715738	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT451470	hsa-miR-524-3p	PAR-CLIP	23592263
MIRT451469	hsa-miR-525-3p	PAR-CLIP	23592263
MIRT451468	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT451467	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT451466	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT451464	hsa-miR-940	PAR-CLIP	23592263
MIRT451465	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT451463	hsa-miR-4514	PAR-CLIP	23592263
MIRT451462	hsa-miR-4692	PAR-CLIP	23592263
MIRT451461	hsa-miR-1273f	PAR-CLIP	23592263
MIRT451460	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451459	hsa-miR-5194	PAR-CLIP	23592263
MIRT451458	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451456	hsa-miR-4534	PAR-CLIP	23592263
MIRT451457	hsa-miR-8082	PAR-CLIP	23592263
MIRT451455	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT451454	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT451453	hsa-miR-4306	PAR-CLIP	23592263
MIRT451452	hsa-miR-4644	PAR-CLIP	23592263
MIRT451451	hsa-miR-5192	PAR-CLIP	23592263
MIRT451449	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT715754	hsa-miR-4259	HITS-CLIP	19536157
MIRT715753	hsa-miR-571	HITS-CLIP	19536157
MIRT715752	hsa-miR-6795-5p	HITS-CLIP	19536157
MIRT715751	hsa-miR-6887-5p	HITS-CLIP	19536157
MIRT715750	hsa-miR-328-5p	HITS-CLIP	19536157
MIRT715749	hsa-miR-6885-5p	HITS-CLIP	19536157
MIRT715748	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT715747	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT715746	hsa-miR-4326	HITS-CLIP	19536157
MIRT715745	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT715744	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT715743	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT715742	hsa-miR-1275	HITS-CLIP	19536157
MIRT715741	hsa-miR-4665-5p	HITS-CLIP	19536157
MIRT715740	hsa-miR-7109-5p	HITS-CLIP	19536157
MIRT715739	hsa-miR-6751-5p	HITS-CLIP	19536157
MIRT715738	hsa-miR-6803-5p	HITS-CLIP	19536157
MIRT451470	hsa-miR-524-3p	PAR-CLIP	23592263
MIRT451469	hsa-miR-525-3p	PAR-CLIP	23592263
MIRT451468	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT451467	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT451466	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT451464	hsa-miR-940	PAR-CLIP	23592263
MIRT451465	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT451463	hsa-miR-4514	PAR-CLIP	23592263
MIRT451462	hsa-miR-4692	PAR-CLIP	23592263
MIRT451461	hsa-miR-1273f	PAR-CLIP	23592263
MIRT451460	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451459	hsa-miR-5194	PAR-CLIP	23592263
MIRT451458	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451456	hsa-miR-4534	PAR-CLIP	23592263
MIRT451457	hsa-miR-8082	PAR-CLIP	23592263
MIRT451455	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT451454	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT451453	hsa-miR-4306	PAR-CLIP	23592263
MIRT451452	hsa-miR-4644	PAR-CLIP	23592263
MIRT451451	hsa-miR-5192	PAR-CLIP	23592263
MIRT451449	hsa-miR-615-5p	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0102196	Function	Cortisol dehydrogenase (NADP+) activity	IDA	19436836
GO:0102196	Function	Cortisol dehydrogenase (NADP+) activity	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q7Z5J1

Protein name

Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) (Short chain dehydrogenase/reductase family 26C member 2) (Short-chain dehydrogenase/reductase 10B)

Protein function

Unidirectional NADP(+)-dependent cortisol dehydrogenase (in vitro).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00106	adh_short	30 → 225	short chain dehydrogenase	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the brain. {ECO:0000269|PubMed:19436836}.

Sequence

MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA
HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP
AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA
AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRSSTSRPRQPEHRGVPLQ
SQTAMFLPPTVPGARTLTETPLRGWPQPKMKSSRQKSKTEKNDGHLEPVTAWEVQVPRVR
RLCRGLARPHLFGHD

Sequence length

315

Interactions

View interactions

KEGG Pathway
Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis - DNA adducts

HSD11B1L (hydroxysteroid 11-beta dehydrogenase 1 like)

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