HP1BP3 (heterochromatin protein 1 binding protein 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 50809 |
| Gene name | Heterochromatin protein 1 binding protein 3 |
| Gene symbol | HP1BP3 |
| Synonyms (NCBI Gene) |
HP1-BP74HP1BP74
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| Chromosome | 1 |
| Chromosome location | 1p36.12 |
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miRNA
miRNA information provided by mirtarbase database.
637
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q5SSJ5 | ||||||||||||||||||||
| Protein name | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | ||||||||||||||||||||
| Protein function | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hy | ||||||||||||||||||||
| PDB | 2RQP | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEG |
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| Sequence length | 553 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with HP1BP3 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to HP1BP3 (see Related Genes above), that are NOT already directly curated for HP1BP3 itself -- a lead worth checking, not a confirmed association.
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