Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	92906
Gene name	Heterogeneous nuclear ribonucleoprotein L like
Gene symbol	HNRNPLL
Synonyms (NCBI Gene)	HNRPLLSRRF
Chromosome	2
Chromosome location	2p22.1
Summary	HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 1

miRTarBase ID	miRNA	Experiments	Reference
MIRT048961	hsa-miR-92a-3p	CLASH	23622248

15 Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IDA	18669861
GO:0005515	Function	Protein binding	IPI	18669861, 21516116, 25416956, 26871637, 29892012, 31515488, 32296183, 32814053, 33961781, 34159380
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0033120	Process	Positive regulation of RNA splicing	IDA	18669861
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0043484	Process	Regulation of RNA splicing	IEA
GO:0045202	Component	Synapse	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611208	25127	ENSG00000143889

Q8WVV9

Protein name

Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor)

Protein function

RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.

PDB

7EVS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	78 → 130	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF11835	RRM_8	159 → 244	RRM-like domain	Domain
PF13893	RRM_5	307 → 433		Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. {ECO:0000269|PubMed:15256261}.

Sequence

MSSSSSSPRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSF
SQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFEN
IDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPI
TVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIE
YARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPL
PSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYG
NIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFEL
EDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVL
TFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSS
HL

Sequence length

542

Interactions

View interactions

Related Genes Genes most often co-reported with HNRNPLL across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for HNRNPLL.

Diseases Linked via Similar Genes Diseases curated for genes most similar to HNRNPLL (see Related Genes above), that are NOT already directly curated for HNRNPLL itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to HNRNPLL.

HNRNPLL (heterogeneous nuclear ribonucleoprotein L like)

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