HMX2 (H6 family homeobox 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 3167
• Gene name: H6 family homeobox 2
• Gene symbol: HMX2
• Synonyms (NCBI Gene): H6L, Nkx5-2
• Chromosome: 10
• Chromosome location: 10q26.13
• Summary: The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in pa

miRNA Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	20371350
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT504397	hsa-miR-598-5p	PAR-CLIP	20371350
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT504394	hsa-miR-640	PAR-CLIP	20371350
MIRT529625	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT529624	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	23446348
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	23446348
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT504397	hsa-miR-598-5p	PAR-CLIP	23446348
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT504394	hsa-miR-640	PAR-CLIP	23446348
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504397	hsa-miR-598-5p	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504394	hsa-miR-640	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	26701625
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	27292025
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	27292025
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	27292025
MIRT504397	hsa-miR-598-5p	PAR-CLIP	27292025
MIRT504394	hsa-miR-640	PAR-CLIP	27292025
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	20371350
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT504397	hsa-miR-598-5p	PAR-CLIP	20371350
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT504394	hsa-miR-640	PAR-CLIP	20371350
MIRT529625	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT529624	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT504402	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT504400	hsa-miR-5586-5p	PAR-CLIP	23446348
MIRT504399	hsa-miR-4691-3p	PAR-CLIP	23446348
MIRT504398	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT504397	hsa-miR-598-5p	PAR-CLIP	23446348
MIRT504396	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT504395	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT504394	hsa-miR-640	PAR-CLIP	23446348
MIRT2451290	hsa-miR-3127-3p	CLIP-seq
MIRT2451291	hsa-miR-4539	CLIP-seq
MIRT2451292	hsa-miR-4680-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0007420	Process	Brain development	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0042472	Process	Inner ear morphogenesis	IEA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IEA
GO:0050673	Process	Epithelial cell proliferation	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IEA
GO:0072089	Process	Stem cell proliferation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000648	Process	Positive regulation of stem cell proliferation	IEA

Other IDs

• MIM: 600647
• HGNC: 5018
• e!Ensembl: ENSG00000188816

Protein

• UniProt ID: A2RU54
• Protein name: Homeobox protein HMX2 (Homeobox protein H6 family member 2)
• Protein function: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	150 → 206	Homeodomain	Domain

• Sequence:

  MGSKEDAGKGCPAAGGVSSFTIQSILGGGPSEAPREPVGWPARKRSLSVSSEEEEPDDGW
  KAPACFCPDQHGPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEK
  ERLLPAGSPSPGSERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERA
  CLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVSMPLVFRDSSLLRV
  PVPRSLAFPAPLYYPGSNLSALPLYNLYNKLDY

• Sequence length: 273

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
High myopia	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HMX2-related disorder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (7)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Astrocytoma	Astrocytoma	Pubtator	33051600	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	19723660	Associate	★☆☆☆☆ Found in Text Mining only
Congenital sensorineural hearing loss	Congenital Sensorineural Hearing Loss	BEFREE	19253379		★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Hearing loss	Pubtator	19253379	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	33048949	Associate	★☆☆☆☆ Found in Text Mining only
Meniere Disease	Meniere Disease	BEFREE	31106404		★☆☆☆☆ Found in Text Mining only
Vestibular Diseases	Vestibular disease	Pubtator	19253379	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for HMX2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HMX2.