HMGN3 (high mobility group nucleosomal binding domain 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9324
• Gene name: High mobility group nucleosomal binding domain 3
• Gene symbol: HMGN3
• Synonyms (NCBI Gene): PNAS-24, PNAS-25, TRIP7
• Chromosome: 6
• Chromosome location: 6q14.1
• Summary: The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancin

miRNA Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT557266	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT557267	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT557265	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT557263	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT557264	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT557262	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT557261	hsa-miR-493-5p	PAR-CLIP	21572407
MIRT557260	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT557266	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT557267	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT557265	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT557263	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT557264	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT557262	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT557261	hsa-miR-493-5p	PAR-CLIP	21572407
MIRT557260	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT1049890	hsa-miR-1	CLIP-seq
MIRT1049891	hsa-miR-1305	CLIP-seq
MIRT1049892	hsa-miR-206	CLIP-seq
MIRT1049893	hsa-miR-217	CLIP-seq
MIRT1049894	hsa-miR-3143	CLIP-seq
MIRT1049895	hsa-miR-3180-5p	CLIP-seq
MIRT1049896	hsa-miR-3185	CLIP-seq
MIRT1049897	hsa-miR-323-3p	CLIP-seq
MIRT1049898	hsa-miR-3673	CLIP-seq
MIRT1049899	hsa-miR-3921	CLIP-seq
MIRT1049900	hsa-miR-4267	CLIP-seq
MIRT1049901	hsa-miR-433	CLIP-seq
MIRT1049902	hsa-miR-4418	CLIP-seq
MIRT1049903	hsa-miR-4438	CLIP-seq
MIRT1049904	hsa-miR-4653-5p	CLIP-seq
MIRT1049905	hsa-miR-4682	CLIP-seq
MIRT1049906	hsa-miR-4714-5p	CLIP-seq
MIRT1049907	hsa-miR-4728-3p	CLIP-seq
MIRT1049908	hsa-miR-4742-5p	CLIP-seq
MIRT1049909	hsa-miR-4765	CLIP-seq
MIRT1049910	hsa-miR-509-3-5p	CLIP-seq
MIRT1049911	hsa-miR-5095	CLIP-seq
MIRT1049912	hsa-miR-509-5p	CLIP-seq
MIRT1049913	hsa-miR-519a	CLIP-seq
MIRT1049914	hsa-miR-519b-3p	CLIP-seq
MIRT1049915	hsa-miR-519c-3p	CLIP-seq
MIRT1049916	hsa-miR-543	CLIP-seq
MIRT1049917	hsa-miR-613	CLIP-seq
MIRT2243629	hsa-miR-2115	CLIP-seq
MIRT2243630	hsa-miR-3145-3p	CLIP-seq
MIRT2243631	hsa-miR-323b-3p	CLIP-seq
MIRT2243632	hsa-miR-325	CLIP-seq
MIRT2243633	hsa-miR-329	CLIP-seq
MIRT2243634	hsa-miR-362-3p	CLIP-seq
MIRT2243635	hsa-miR-3923	CLIP-seq
MIRT2243636	hsa-miR-3941	CLIP-seq
MIRT2243637	hsa-miR-411	CLIP-seq
MIRT2243638	hsa-miR-466	CLIP-seq
MIRT2243639	hsa-miR-4668-3p	CLIP-seq
MIRT2243640	hsa-miR-4672	CLIP-seq
MIRT2243641	hsa-miR-548aa	CLIP-seq
MIRT2243642	hsa-miR-600	CLIP-seq
MIRT2243643	hsa-miR-603	CLIP-seq
MIRT2546795	hsa-miR-1179	CLIP-seq
MIRT2546796	hsa-miR-1185	CLIP-seq
MIRT2546797	hsa-miR-1224-5p	CLIP-seq
MIRT2546798	hsa-miR-139-3p	CLIP-seq
MIRT2243629	hsa-miR-2115	CLIP-seq
MIRT2243630	hsa-miR-3145-3p	CLIP-seq
MIRT2546799	hsa-miR-3163	CLIP-seq
MIRT2546800	hsa-miR-3171	CLIP-seq
MIRT2243631	hsa-miR-323b-3p	CLIP-seq
MIRT2243632	hsa-miR-325	CLIP-seq
MIRT2243633	hsa-miR-329	CLIP-seq
MIRT2546801	hsa-miR-3605-5p	CLIP-seq
MIRT2243634	hsa-miR-362-3p	CLIP-seq
MIRT2546802	hsa-miR-3662	CLIP-seq
MIRT2546803	hsa-miR-3679-5p	CLIP-seq
MIRT2546804	hsa-miR-382	CLIP-seq
MIRT2546805	hsa-miR-3915	CLIP-seq
MIRT2243635	hsa-miR-3923	CLIP-seq
MIRT2243636	hsa-miR-3941	CLIP-seq
MIRT2243637	hsa-miR-411	CLIP-seq
MIRT2546806	hsa-miR-4422	CLIP-seq
MIRT2546807	hsa-miR-4495	CLIP-seq
MIRT2546808	hsa-miR-4646-3p	CLIP-seq
MIRT2243638	hsa-miR-466	CLIP-seq
MIRT2243639	hsa-miR-4668-3p	CLIP-seq
MIRT2243640	hsa-miR-4672	CLIP-seq
MIRT2546809	hsa-miR-4689	CLIP-seq
MIRT2546810	hsa-miR-4712-3p	CLIP-seq
MIRT2546811	hsa-miR-513a-3p	CLIP-seq
MIRT2546812	hsa-miR-520d-5p	CLIP-seq
MIRT2546813	hsa-miR-524-5p	CLIP-seq
MIRT2546814	hsa-miR-548c-3p	CLIP-seq
MIRT2546815	hsa-miR-548n	CLIP-seq
MIRT2546816	hsa-miR-548t	CLIP-seq
MIRT2243643	hsa-miR-603	CLIP-seq
MIRT2546817	hsa-miR-890	CLIP-seq
MIRT2546795	hsa-miR-1179	CLIP-seq
MIRT2546796	hsa-miR-1185	CLIP-seq
MIRT2546797	hsa-miR-1224-5p	CLIP-seq
MIRT2546798	hsa-miR-139-3p	CLIP-seq
MIRT2243629	hsa-miR-2115	CLIP-seq
MIRT2243630	hsa-miR-3145-3p	CLIP-seq
MIRT2546799	hsa-miR-3163	CLIP-seq
MIRT2546800	hsa-miR-3171	CLIP-seq
MIRT2243631	hsa-miR-323b-3p	CLIP-seq
MIRT2243632	hsa-miR-325	CLIP-seq
MIRT2243633	hsa-miR-329	CLIP-seq
MIRT2546801	hsa-miR-3605-5p	CLIP-seq
MIRT2243634	hsa-miR-362-3p	CLIP-seq
MIRT2546802	hsa-miR-3662	CLIP-seq
MIRT2546803	hsa-miR-3679-5p	CLIP-seq
MIRT2546804	hsa-miR-382	CLIP-seq
MIRT2546805	hsa-miR-3915	CLIP-seq
MIRT2243635	hsa-miR-3923	CLIP-seq
MIRT2243636	hsa-miR-3941	CLIP-seq
MIRT2243637	hsa-miR-411	CLIP-seq
MIRT2546806	hsa-miR-4422	CLIP-seq
MIRT2546807	hsa-miR-4495	CLIP-seq
MIRT2546808	hsa-miR-4646-3p	CLIP-seq
MIRT2243638	hsa-miR-466	CLIP-seq
MIRT2243639	hsa-miR-4668-3p	CLIP-seq
MIRT2243640	hsa-miR-4672	CLIP-seq
MIRT2546809	hsa-miR-4689	CLIP-seq
MIRT2546810	hsa-miR-4712-3p	CLIP-seq
MIRT2546811	hsa-miR-513a-3p	CLIP-seq
MIRT2546812	hsa-miR-520d-5p	CLIP-seq
MIRT2546813	hsa-miR-524-5p	CLIP-seq
MIRT2546814	hsa-miR-548c-3p	CLIP-seq
MIRT2546815	hsa-miR-548n	CLIP-seq
MIRT2546816	hsa-miR-548t	CLIP-seq
MIRT2243643	hsa-miR-603	CLIP-seq
MIRT2546817	hsa-miR-890	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	33468658
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	IBA
GO:0006325	Process	Chromatin organization	IEA
GO:0031492	Function	Nucleosomal DNA binding	IEA
GO:0046966	Function	Nuclear thyroid hormone receptor binding	NAS	7776974

Other IDs

• MIM: 604502
• HGNC: 12312
• e!Ensembl: ENSG00000118418

Protein

• UniProt ID: Q15651
• Protein name: High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7)
• Protein function: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01101	HMG14_17	1 → 97	HMG14 and HMG17	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. {ECO:0000269|PubMed:11356838, ECO:0000269|PubMed:7776974}.
• Sequence:

  MPKRKSPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGA
  KGKKEEKQEAGKEGTAPSENGETKAEEAQKTESVDNEGE

• Sequence length: 99

Related Genes

No strongly related genes found yet for HMGN3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HMGN3.