HIRIP3 (HIRA interacting protein 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8479
• Gene name: HIRA interacting protein 3
• Gene symbol: HIRIP3
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of

miRNA Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037067	hsa-miR-877-3p	CLASH	23622248
MIRT451595	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT486106	hsa-miR-6750-5p	PAR-CLIP	23592263
MIRT486105	hsa-miR-6822-5p	PAR-CLIP	23592263
MIRT451591	hsa-miR-1972	PAR-CLIP	23592263
MIRT451588	hsa-miR-765	PAR-CLIP	23592263
MIRT451585	hsa-miR-3689d	PAR-CLIP	23592263
MIRT451584	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT451579	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT451577	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT451595	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT451594	hsa-miR-2682-5p	PAR-CLIP	23592263
MIRT451593	hsa-miR-34b-5p	PAR-CLIP	23592263
MIRT451592	hsa-miR-449c-5p	PAR-CLIP	23592263
MIRT451591	hsa-miR-1972	PAR-CLIP	23592263
MIRT451590	hsa-miR-1827	PAR-CLIP	23592263
MIRT451589	hsa-miR-6134	PAR-CLIP	23592263
MIRT451588	hsa-miR-765	PAR-CLIP	23592263
MIRT451587	hsa-miR-3612	PAR-CLIP	23592263
MIRT451586	hsa-miR-650	PAR-CLIP	23592263
MIRT451585	hsa-miR-3689d	PAR-CLIP	23592263
MIRT451584	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT451583	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT451582	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT451581	hsa-miR-449a	PAR-CLIP	23592263
MIRT451580	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT451579	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT451577	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT451578	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT451576	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT451575	hsa-miR-4443	PAR-CLIP	23592263
MIRT451595	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT486106	hsa-miR-6750-5p	PAR-CLIP	23592263
MIRT486105	hsa-miR-6822-5p	PAR-CLIP	23592263
MIRT451591	hsa-miR-1972	PAR-CLIP	23592263
MIRT451588	hsa-miR-765	PAR-CLIP	23592263
MIRT451585	hsa-miR-3689d	PAR-CLIP	23592263
MIRT451584	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT451579	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT451577	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT451595	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT451594	hsa-miR-2682-5p	PAR-CLIP	23592263
MIRT451593	hsa-miR-34b-5p	PAR-CLIP	23592263
MIRT451592	hsa-miR-449c-5p	PAR-CLIP	23592263
MIRT451591	hsa-miR-1972	PAR-CLIP	23592263
MIRT451590	hsa-miR-1827	PAR-CLIP	23592263
MIRT451589	hsa-miR-6134	PAR-CLIP	23592263
MIRT451588	hsa-miR-765	PAR-CLIP	23592263
MIRT451587	hsa-miR-3612	PAR-CLIP	23592263
MIRT451586	hsa-miR-650	PAR-CLIP	23592263
MIRT451585	hsa-miR-3689d	PAR-CLIP	23592263
MIRT451584	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT451583	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT451582	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT451581	hsa-miR-449a	PAR-CLIP	23592263
MIRT451580	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT451579	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT451577	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT451578	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT451576	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT451575	hsa-miR-4443	PAR-CLIP	23592263
MIRT2010765	hsa-miR-3189-3p	CLIP-seq
MIRT2010766	hsa-miR-342-5p	CLIP-seq
MIRT2010767	hsa-miR-3657	CLIP-seq
MIRT2010768	hsa-miR-3689a-3p	CLIP-seq
MIRT2010769	hsa-miR-3689c	CLIP-seq
MIRT2010770	hsa-miR-3924	CLIP-seq
MIRT2010771	hsa-miR-4300	CLIP-seq
MIRT2010772	hsa-miR-4664-5p	CLIP-seq
MIRT2010773	hsa-miR-4666-5p	CLIP-seq
MIRT2010774	hsa-miR-4669	CLIP-seq
MIRT2010775	hsa-miR-581	CLIP-seq
MIRT2010776	hsa-miR-592	CLIP-seq
MIRT2010777	hsa-miR-599	CLIP-seq
MIRT2010778	hsa-miR-920	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000511	Function	H2A-H2B histone complex chaperone activity	IDA	38334665
GO:0000511	Function	H2A-H2B histone complex chaperone activity	IMP	38334665
GO:0005515	Function	Protein binding	IPI	9710638, 32296183, 32814053, 33961781, 34819669
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17391060, 38334665
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9710638
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0006325	Process	Chromatin organization	IDA	38334665
GO:0006325	Process	Chromatin organization	IEA
GO:0006325	Process	Chromatin organization	TAS	9710638

Other IDs

• MIM: 603365
• HGNC: 4917
• e!Ensembl: ENSG00000149929

Protein

• UniProt ID: Q9BW71
• Protein name: HIRA-interacting protein 3
• Protein function: Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09649	CHZ	485 → 518	Histone chaperone domain CHZ	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart. {ECO:0000269|PubMed:9710638}.
• Sequence:

  MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLK
  MQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGV
  AAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ
  APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE
  EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAAS
  SGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSG
  EESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRG
  EDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRAL
  KEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPP
  DWSHMRGIISSDGESN

• Sequence length: 556

Related Genes

No strongly related genes found yet for HIRIP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HIRIP3.