HINFP (histone H4 transcription factor)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25988
• Gene name: Histone H4 transcription factor
• Gene symbol: HINFP
• Synonyms (NCBI Gene): HiNF-P, MIZF, ZNF743
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcri

miRNA Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT723026	hsa-miR-217	HITS-CLIP	19536157
MIRT723025	hsa-miR-6807-3p	HITS-CLIP	19536157
MIRT723024	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT723023	hsa-miR-20a-3p	HITS-CLIP	19536157
MIRT723022	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT677017	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT677016	hsa-miR-5683	HITS-CLIP	23824327
MIRT677015	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT677014	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677013	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677012	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677011	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677010	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677009	hsa-miR-1976	HITS-CLIP	23824327
MIRT637377	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677008	hsa-miR-3199	HITS-CLIP	23824327
MIRT677007	hsa-miR-8052	HITS-CLIP	23824327
MIRT677006	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677005	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677004	hsa-miR-4279	HITS-CLIP	23824327
MIRT637384	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT637382	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT637383	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT637381	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT637380	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT637379	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT637378	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT637377	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT637376	hsa-miR-4284	HITS-CLIP	23824327
MIRT637375	hsa-miR-7641	HITS-CLIP	23824327
MIRT610897	hsa-miR-548p	HITS-CLIP	23824327
MIRT610896	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT610895	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT610894	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT610893	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT516923	hsa-miR-483-5p	PAR-CLIP	23446348
MIRT516918	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516922	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT516921	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT516920	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516919	hsa-miR-1227-3p	PAR-CLIP	23446348
MIRT516918	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516917	hsa-miR-4715-3p	PAR-CLIP	23446348
MIRT516916	hsa-miR-6083	PAR-CLIP	23446348
MIRT516915	hsa-miR-1303	PAR-CLIP	23446348
MIRT723026	hsa-miR-217	HITS-CLIP	19536157
MIRT723025	hsa-miR-6807-3p	HITS-CLIP	19536157
MIRT723024	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT723023	hsa-miR-20a-3p	HITS-CLIP	19536157
MIRT723022	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT677017	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT677016	hsa-miR-5683	HITS-CLIP	23824327
MIRT677015	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT677014	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677013	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677012	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677011	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677010	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677009	hsa-miR-1976	HITS-CLIP	23824327
MIRT637377	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677008	hsa-miR-3199	HITS-CLIP	23824327
MIRT677007	hsa-miR-8052	HITS-CLIP	23824327
MIRT677006	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677005	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677004	hsa-miR-4279	HITS-CLIP	23824327
MIRT637384	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT637382	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT637383	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT637381	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT637380	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT637379	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT637378	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT637377	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT637376	hsa-miR-4284	HITS-CLIP	23824327
MIRT637375	hsa-miR-7641	HITS-CLIP	23824327
MIRT610897	hsa-miR-548p	HITS-CLIP	23824327
MIRT610896	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT610895	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT610894	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT610893	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT516923	hsa-miR-483-5p	PAR-CLIP	23446348
MIRT516918	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516922	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT516921	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT516920	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516919	hsa-miR-1227-3p	PAR-CLIP	23446348
MIRT516918	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516917	hsa-miR-4715-3p	PAR-CLIP	23446348
MIRT516916	hsa-miR-6083	PAR-CLIP	23446348
MIRT516915	hsa-miR-1303	PAR-CLIP	23446348
MIRT1046071	hsa-miR-1208	CLIP-seq
MIRT1046072	hsa-miR-34b	CLIP-seq
MIRT1046073	hsa-miR-1184	CLIP-seq
MIRT1046074	hsa-miR-1205	CLIP-seq
MIRT1046075	hsa-miR-1322	CLIP-seq
MIRT1046076	hsa-miR-2053	CLIP-seq
MIRT1046077	hsa-miR-298	CLIP-seq
MIRT1046078	hsa-miR-3158-5p	CLIP-seq
MIRT1046079	hsa-miR-4421	CLIP-seq
MIRT1046080	hsa-miR-569	CLIP-seq
MIRT1046081	hsa-miR-574-3p	CLIP-seq
MIRT2242602	hsa-miR-3155	CLIP-seq
MIRT2242603	hsa-miR-3155b	CLIP-seq
MIRT2242604	hsa-miR-4286	CLIP-seq
MIRT2242605	hsa-miR-4698	CLIP-seq
MIRT2242606	hsa-miR-484	CLIP-seq
MIRT2546141	hsa-miR-1254	CLIP-seq
MIRT2546142	hsa-miR-149	CLIP-seq
MIRT2546143	hsa-miR-2110	CLIP-seq
MIRT2546144	hsa-miR-24	CLIP-seq
MIRT2546145	hsa-miR-3064-5p	CLIP-seq
MIRT2546146	hsa-miR-3116	CLIP-seq
MIRT2546147	hsa-miR-3194-3p	CLIP-seq
MIRT2546148	hsa-miR-3661	CLIP-seq
MIRT2546149	hsa-miR-371-5p	CLIP-seq
MIRT2546150	hsa-miR-4252	CLIP-seq
MIRT2546151	hsa-miR-4271	CLIP-seq
MIRT2546152	hsa-miR-4436a	CLIP-seq
MIRT2546153	hsa-miR-4527	CLIP-seq
MIRT2546154	hsa-miR-4667-5p	CLIP-seq
MIRT2546155	hsa-miR-4700-5p	CLIP-seq
MIRT2546156	hsa-miR-4725-3p	CLIP-seq
MIRT2546157	hsa-miR-4794	CLIP-seq
MIRT2546158	hsa-miR-492	CLIP-seq
MIRT2546159	hsa-miR-522	CLIP-seq
MIRT2546160	hsa-miR-631	CLIP-seq
MIRT2546161	hsa-miR-661	CLIP-seq
MIRT2546162	hsa-miR-760	CLIP-seq
MIRT2546141	hsa-miR-1254	CLIP-seq
MIRT2546142	hsa-miR-149	CLIP-seq
MIRT2546143	hsa-miR-2110	CLIP-seq
MIRT2546144	hsa-miR-24	CLIP-seq
MIRT2546145	hsa-miR-3064-5p	CLIP-seq
MIRT2546146	hsa-miR-3116	CLIP-seq
MIRT2546148	hsa-miR-3661	CLIP-seq
MIRT2546149	hsa-miR-371-5p	CLIP-seq
MIRT2546150	hsa-miR-4252	CLIP-seq
MIRT2546151	hsa-miR-4271	CLIP-seq
MIRT2546152	hsa-miR-4436a	CLIP-seq
MIRT2546153	hsa-miR-4527	CLIP-seq
MIRT2546154	hsa-miR-4667-5p	CLIP-seq
MIRT2546155	hsa-miR-4700-5p	CLIP-seq
MIRT2546156	hsa-miR-4725-3p	CLIP-seq
MIRT2546157	hsa-miR-4794	CLIP-seq
MIRT2546158	hsa-miR-492	CLIP-seq
MIRT2546159	hsa-miR-522	CLIP-seq
MIRT2546160	hsa-miR-631	CLIP-seq
MIRT2546161	hsa-miR-661	CLIP-seq
MIRT2546162	hsa-miR-760	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREBBP	Activation	17826007
EP300	Activation	17826007

Gene ontology (GO) Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000077	Process	DNA damage checkpoint signaling	IMP	17974976
GO:0000082	Process	G1/S transition of mitotic cell cycle	IMP	14585971
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	14752047, 15541338, 15988025, 17974976
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	18850719
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	18850719, 19170105
GO:0001701	Process	In utero embryonic development	IEA
GO:0001701	Process	In utero embryonic development	ISS
GO:0003677	Function	DNA binding	IDA	9540062, 18850719
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IMP	9540062
GO:0005515	Function	Protein binding	IPI	11553631, 15988025, 17577209, 18850719, 32296183
GO:0005634	Component	Nucleus	IDA	14585971, 15988025, 18850719
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	11553631
GO:0005730	Component	Nucleolus	IDA	11553631
GO:0006281	Process	DNA repair	IMP	17974976
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	9540062
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	14585971, 17974976
GO:0010629	Process	Negative regulation of gene expression	IMP	15541338, 17974976
GO:0015030	Component	Cajal body	IDA	15988025
GO:0019899	Function	Enzyme binding	IPI	11553631
GO:0042393	Function	Histone binding	IPI	9540062, 14585971
GO:0044843	Process	Cell cycle G1/S phase transition	IMP	15988025
GO:0045184	Process	Establishment of protein localization	IMP	15988025
GO:0045445	Process	Myoblast differentiation	IMP	15541338
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	11553631, 14752047, 15541338, 17163457
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	14585971, 17163457, 17974976
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	18850719
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 607099
• HGNC: 17850
• e!Ensembl: ENSG00000172273

Protein

• UniProt ID: Q9BQA5
• Protein name: Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein)
• Protein function: Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates tr
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	345 → 368	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	255 → 278	Zinc finger, C2H2 type	Domain
  PF13894	zf-C2H2_4	229 → 252		Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver. {ECO:0000269|PubMed:11553631}.
• Sequence:

  MPPPGKVPRKENLWLQCEWGSCSFVCSTMEKFFEHVTQHLQQHLHGSGEEEEEEEEDDPL
  EEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQADLGPCILDFQSRN
  VIPDIPDHFLCLWEHCENSFDNPEWFYRHVEAHSLCCEYEAVGKDNPVVLCGWKGCTCTF
  KDRSKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQTSLDQQHFQCSHCSKRFAT
  ERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEDRPFKCDCCDYSCKNLIDLQ
  KHLDTHSEEPAYRCDFENCTFSARSLCSIKSHYRKVHEGDSEPRYKCHVCDKCFTRGNNL
  TVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLRQPQEGSGLGTSLN
  ESSLQGIILETVPGEPGRKEEEEEGKGSEGTALSASQDNPSSVIHVVNQTNAQGQQEIVY
  YVLSEAPGEPPPAPEPPSGGIMEKLQGIAEEPEIQMV

• Sequence length: 517

Related Genes

No strongly related genes found yet for HINFP.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HINFP.