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Gene Gene information from NCBI Gene database.
Entrez ID 23119
Gene name HIC ZBTB transcriptional repressor 2
Gene symbol HIC2
Synonyms (NCBI Gene)
HRG22ZBTB30ZNF907
Chromosome 22
Chromosome location 22q11.21
miRNA miRNA information provided by mirtarbase database.
1121 Show/Hide all (1121)
miRTarBase ID miRNA Experiments Reference
MIRT016094 hsa-miR-769-5p Sequencing 20371350
MIRT023435 hsa-miR-30b-5p Sequencing 20371350
MIRT030600 hsa-miR-24-3p Microarray 19748357
MIRT043900 hsa-miR-378a-3p CLASH 23622248
MIRT042187 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
GO:0001817 Process Regulation of cytokine production IBA
GO:0002682 Process Regulation of immune system process IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607712 18595 ENSG00000169635
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96JB3
Protein name Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30)
Protein function Transcriptional repressor.
PDB 7TXC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 533 → 555 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 561 → 583 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 589 → 611 Zinc finger, C2H2 type Domain
PF00651 BTB 36 → 143 BTB/POZ domain Domain
PF13894 zf-C2H2_4 505 → 528 Domain
Tissue specificity TISSUE SPECIFICITY: Highest levels in cerebellum.
Sequence
MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAH
KNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLL
TAASYLQLPELAALCRRKLKRAG
KPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVD
GRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGG
CEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGG
TPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGP
CPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGH
ASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETG
SGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGK
MFTQRGTMTRHMRSH
LGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQ
QRNLISHLRMH
TSPS
Sequence length 615
Interactions View interactions