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Gene Gene information from NCBI Gene database.
Entrez ID 54626
Gene name Hes family bHLH transcription factor 2
Gene symbol HES2
Synonyms (NCBI Gene)
bHLHb40
Chromosome 1
Chromosome location 1p36.31
miRNA miRNA information provided by mirtarbase database.
450 Show/Hide all (450)
miRTarBase ID miRNA Experiments Reference
MIRT018989 hsa-miR-335-5p Microarray 18185580
MIRT633567 hsa-miR-6813-3p HITS-CLIP 23824327
MIRT633566 hsa-miR-125a-3p HITS-CLIP 23824327
MIRT645140 hsa-miR-764 HITS-CLIP 23824327
MIRT645139 hsa-miR-3934-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18 Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609970 16005 ENSG00000069812
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y543
Protein name Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2)
Protein function Transcriptional repressor of genes that require a bHLH protein for their transcription.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 14 → 71 Helix-loop-helix DNA-binding domain Domain
PF07527 Hairy_orange 85 → 124 Hairy Orange Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors. {ECO:0000269|PubMed:15254753}.
Sequence
MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVL
EMTVRFLQELP
ASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLW
RRAA
SATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW
Sequence length 173
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Human papillomavirus infection