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Gene Gene information from NCBI Gene database.
Entrez ID 3068
Gene name Heparin binding growth factor
Gene symbol HDGF
Synonyms (NCBI Gene)
HMG1L2
Chromosome 1
Chromosome location 1q23.1
Summary This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growt
miRNA miRNA information provided by mirtarbase database.
851 Show/Hide all (851)
miRTarBase ID miRNA Experiments Reference
MIRT020405 hsa-miR-29c-3p Sequencing 20371350
MIRT049930 hsa-miR-30a-5p CLASH 23622248
MIRT049138 hsa-miR-92a-3p CLASH 23622248
MIRT048885 hsa-miR-93-5p CLASH 23622248
MIRT046638 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37 Show/Hide all (37)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 19162039
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000166 Function Nucleotide binding IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0001222 Function Transcription corepressor binding IPI 19162039
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600339 4856 ENSG00000143321
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51858
Protein name Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)
Protein function [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618,
PDB 1RI0 , 2NLU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00855 PWWP 10 → 94 PWWP domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:7929202}.
Sequence
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGP
KDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPT
VKASGYQSSQKKSCVEEPEPEPEAAE
GDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEK
EAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL
Sequence length 240
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
XBP1(S) activates chaperone genes