HABP4 (hyaluronan binding protein 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 22927
• Gene name: Hyaluronan binding protein 4
• Gene symbol: HABP4
• Synonyms (NCBI Gene): IHABP-4, IHABP4, Ki-1/57, SERBP1L
• Chromosome: 9
• Chromosome location: 9q22.32

miRNA Show/Hide all (209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020318	hsa-miR-130b-3p	Sequencing	20371350
MIRT031235	hsa-miR-19b-3p	Sequencing	20371350
MIRT108267	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT108266	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT108265	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT536992	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT536991	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT536990	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT536989	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT536988	hsa-miR-302e	PAR-CLIP	21572407
MIRT536987	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT536986	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT536985	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT536984	hsa-miR-520b	PAR-CLIP	21572407
MIRT536983	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT536982	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT536981	hsa-miR-520e	PAR-CLIP	21572407
MIRT108261	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT020318	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT108263	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT108269	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT108272	hsa-miR-3666	PAR-CLIP	21572407
MIRT108271	hsa-miR-4295	PAR-CLIP	21572407
MIRT108268	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT536980	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT536979	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT536978	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT536977	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT536976	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT536975	hsa-miR-4775	PAR-CLIP	21572407
MIRT536974	hsa-miR-578	PAR-CLIP	21572407
MIRT108261	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT108268	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT108271	hsa-miR-4295	PAR-CLIP	22012620
MIRT108272	hsa-miR-3666	PAR-CLIP	22012620
MIRT108269	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT108263	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT020318	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT536992	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536991	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536990	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536989	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536988	hsa-miR-302e	PAR-CLIP	22012620
MIRT536987	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536986	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536985	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536984	hsa-miR-520b	PAR-CLIP	22012620
MIRT536983	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536982	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536981	hsa-miR-520e	PAR-CLIP	22012620
MIRT536980	hsa-miR-30a-5p	PAR-CLIP	22012620
MIRT536979	hsa-miR-30b-5p	PAR-CLIP	22012620
MIRT536978	hsa-miR-30c-5p	PAR-CLIP	22012620
MIRT536977	hsa-miR-30d-5p	PAR-CLIP	22012620
MIRT536976	hsa-miR-30e-5p	PAR-CLIP	22012620
MIRT536975	hsa-miR-4775	PAR-CLIP	22012620
MIRT536974	hsa-miR-578	PAR-CLIP	22012620
MIRT440526	hsa-miR-323a-5p	HITS-CLIP	24374217
MIRT440526	hsa-miR-323a-5p	HITS-CLIP	24374217
MIRT108267	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT108266	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT108265	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT536992	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT536991	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT536990	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT536989	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT536988	hsa-miR-302e	PAR-CLIP	21572407
MIRT536987	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT536986	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT536985	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT536984	hsa-miR-520b	PAR-CLIP	21572407
MIRT536983	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT536982	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT536981	hsa-miR-520e	PAR-CLIP	21572407
MIRT108261	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT020318	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT108263	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT108269	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT108272	hsa-miR-3666	PAR-CLIP	21572407
MIRT108271	hsa-miR-4295	PAR-CLIP	21572407
MIRT108268	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT536980	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT536979	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT536978	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT536977	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT536976	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT536975	hsa-miR-4775	PAR-CLIP	21572407
MIRT536974	hsa-miR-578	PAR-CLIP	21572407
MIRT108261	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT108268	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT108271	hsa-miR-4295	PAR-CLIP	22012620
MIRT108272	hsa-miR-3666	PAR-CLIP	22012620
MIRT108269	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT108263	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT020318	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT536992	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536991	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536990	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536989	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536988	hsa-miR-302e	PAR-CLIP	22012620
MIRT536987	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536986	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536985	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536984	hsa-miR-520b	PAR-CLIP	22012620
MIRT536983	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536982	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536981	hsa-miR-520e	PAR-CLIP	22012620
MIRT536980	hsa-miR-30a-5p	PAR-CLIP	22012620
MIRT536979	hsa-miR-30b-5p	PAR-CLIP	22012620
MIRT536978	hsa-miR-30c-5p	PAR-CLIP	22012620
MIRT536977	hsa-miR-30d-5p	PAR-CLIP	22012620
MIRT536976	hsa-miR-30e-5p	PAR-CLIP	22012620
MIRT536975	hsa-miR-4775	PAR-CLIP	22012620
MIRT536974	hsa-miR-578	PAR-CLIP	22012620
MIRT1040332	hsa-miR-1207-3p	CLIP-seq
MIRT1040333	hsa-miR-1284	CLIP-seq
MIRT1040334	hsa-miR-147	CLIP-seq
MIRT1040335	hsa-miR-1470	CLIP-seq
MIRT1040336	hsa-miR-203	CLIP-seq
MIRT1040337	hsa-miR-2115	CLIP-seq
MIRT1040338	hsa-miR-326	CLIP-seq
MIRT1040339	hsa-miR-330-5p	CLIP-seq
MIRT1040340	hsa-miR-3675-3p	CLIP-seq
MIRT1040341	hsa-miR-3911	CLIP-seq
MIRT1040342	hsa-miR-4267	CLIP-seq
MIRT1040343	hsa-miR-4294	CLIP-seq
MIRT1040344	hsa-miR-4446-5p	CLIP-seq
MIRT1040345	hsa-miR-4474-3p	CLIP-seq
MIRT1040346	hsa-miR-4643	CLIP-seq
MIRT1040347	hsa-miR-466	CLIP-seq
MIRT1040348	hsa-miR-4667-3p	CLIP-seq
MIRT1040349	hsa-miR-4755-5p	CLIP-seq
MIRT1040350	hsa-miR-4759	CLIP-seq
MIRT1040351	hsa-miR-4789-3p	CLIP-seq
MIRT1040352	hsa-miR-4789-5p	CLIP-seq
MIRT1040353	hsa-miR-4796-5p	CLIP-seq
MIRT1040354	hsa-miR-512-5p	CLIP-seq
MIRT1040355	hsa-miR-516a-3p	CLIP-seq
MIRT1040356	hsa-miR-539	CLIP-seq
MIRT1040357	hsa-miR-548a-3p	CLIP-seq
MIRT1040358	hsa-miR-548ae	CLIP-seq
MIRT1040359	hsa-miR-548aj	CLIP-seq
MIRT1040360	hsa-miR-548am	CLIP-seq
MIRT1040361	hsa-miR-548e	CLIP-seq
MIRT1040362	hsa-miR-548f	CLIP-seq
MIRT1040363	hsa-miR-548x	CLIP-seq
MIRT1040364	hsa-miR-579	CLIP-seq
MIRT1040365	hsa-miR-642a	CLIP-seq
MIRT1040366	hsa-miR-644	CLIP-seq
MIRT1040367	hsa-miR-658	CLIP-seq
MIRT1040368	hsa-miR-760	CLIP-seq
MIRT1040369	hsa-miR-765	CLIP-seq
MIRT1040370	hsa-miR-937	CLIP-seq
MIRT2008408	hsa-let-7a	CLIP-seq
MIRT2008409	hsa-let-7b	CLIP-seq
MIRT2008410	hsa-let-7c	CLIP-seq
MIRT2008411	hsa-let-7d	CLIP-seq
MIRT2008412	hsa-let-7e	CLIP-seq
MIRT2008413	hsa-let-7f	CLIP-seq
MIRT2008414	hsa-let-7g	CLIP-seq
MIRT2008415	hsa-let-7i	CLIP-seq
MIRT2008416	hsa-miR-145	CLIP-seq
MIRT2008417	hsa-miR-196a	CLIP-seq
MIRT2008418	hsa-miR-196b	CLIP-seq
MIRT2008419	hsa-miR-330-3p	CLIP-seq
MIRT2008420	hsa-miR-4458	CLIP-seq
MIRT2008421	hsa-miR-4500	CLIP-seq
MIRT1040346	hsa-miR-4643	CLIP-seq
MIRT1040347	hsa-miR-466	CLIP-seq
MIRT1040351	hsa-miR-4789-3p	CLIP-seq
MIRT2008422	hsa-miR-98	CLIP-seq
MIRT2240902	hsa-miR-28-3p	CLIP-seq
MIRT2240903	hsa-miR-4640-3p	CLIP-seq
MIRT2240904	hsa-miR-4704-5p	CLIP-seq
MIRT2240905	hsa-miR-576-3p	CLIP-seq
MIRT1040332	hsa-miR-1207-3p	CLIP-seq
MIRT2544416	hsa-miR-1301	CLIP-seq
MIRT2544417	hsa-miR-148a	CLIP-seq
MIRT2544418	hsa-miR-148b	CLIP-seq
MIRT2544419	hsa-miR-152	CLIP-seq
MIRT2544420	hsa-miR-2116	CLIP-seq
MIRT2544421	hsa-miR-3136-3p	CLIP-seq
MIRT2544422	hsa-miR-3148	CLIP-seq
MIRT2544423	hsa-miR-3153	CLIP-seq
MIRT2544424	hsa-miR-328	CLIP-seq
MIRT2544425	hsa-miR-3934	CLIP-seq
MIRT2544426	hsa-miR-3944-5p	CLIP-seq
MIRT2544427	hsa-miR-4273	CLIP-seq
MIRT2544428	hsa-miR-4286	CLIP-seq
MIRT2544429	hsa-miR-4287	CLIP-seq
MIRT2544430	hsa-miR-4434	CLIP-seq
MIRT2544431	hsa-miR-4462	CLIP-seq
MIRT2544432	hsa-miR-4516	CLIP-seq
MIRT2544433	hsa-miR-4531	CLIP-seq
MIRT2544434	hsa-miR-4660	CLIP-seq
MIRT2544435	hsa-miR-4668-5p	CLIP-seq
MIRT2544436	hsa-miR-4677-5p	CLIP-seq
MIRT2544437	hsa-miR-4681	CLIP-seq
MIRT2544438	hsa-miR-4685-3p	CLIP-seq
MIRT2544439	hsa-miR-4778-3p	CLIP-seq
MIRT2544440	hsa-miR-4780	CLIP-seq
MIRT2544441	hsa-miR-5047	CLIP-seq
MIRT2544442	hsa-miR-516a-5p	CLIP-seq
MIRT2544443	hsa-miR-516b	CLIP-seq
MIRT2544444	hsa-miR-552	CLIP-seq
MIRT2544445	hsa-miR-602	CLIP-seq
MIRT2544446	hsa-miR-623	CLIP-seq
MIRT2544447	hsa-miR-635	CLIP-seq
MIRT2544448	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15862299, 16169070, 16879614, 19523114, 21771594
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	16879614, 19523114
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005730	Component	Nucleolus	IDA	19523114
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16879614, 19523114
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0010494	Component	Cytoplasmic stress granule	IDA	21771594
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0015030	Component	Cajal body	IDA	19523114
GO:0015030	Component	Cajal body	IEA
GO:0016528	Component	Sarcoplasm	IEA
GO:0016604	Component	Nuclear body	IEA
GO:0016607	Component	Nuclear speck	IDA	19523114
GO:0016607	Component	Nuclear speck	IEA
GO:0030017	Component	Sarcomere	IEA
GO:0030017	Component	Sarcomere	ISS
GO:0030578	Process	PML body organization	IDA	28695742
GO:0031965	Component	Nuclear membrane	IDA
GO:0032183	Function	SUMO binding	IDA	28695742
GO:0033120	Process	Positive regulation of RNA splicing	IBA
GO:0033120	Process	Positive regulation of RNA splicing	IMP	19523114
GO:0043022	Function	Ribosome binding	ISS
GO:0045948	Process	Positive regulation of translational initiation	IBA
GO:0045948	Process	Positive regulation of translational initiation	IMP	21771594
GO:0061770	Function	Translation elongation factor binding	ISS
GO:0071260	Process	Cellular response to mechanical stimulus	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	ISS
GO:0097504	Component	Gemini of Cajal bodies	IDA	19523114
GO:0097504	Component	Gemini of Cajal bodies	IEA
GO:0141014	Process	Ribosome hibernation	ISS

Other IDs

• MIM: 617369
• HGNC: 17062
• e!Ensembl: ENSG00000130956

Protein

• UniProt ID: Q5JVS0
• Protein name: Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen)
• Protein function: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04774	HABP4_PAI-RBP1	212 → 316	Hyaluronan / mRNA binding family	Family
  PF16174	IHABP4_N	16 → 163	Intracellular hyaluronan-binding protein 4 N-terminal	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes. {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:95
• Sequence:

  MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDE
  AAAAAGAGPRGGRSPAGASGHRAGAGGRRESQKERKSLPAPVAQRPDSPGGGLQAPGQKR
  TPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEKPGDRFDRDR
  PLRGRGGPRGGMRGRGRGGPGNRVFDAFDQRGKREFERYGGNDKIAVRTEDNMGGCGVRT
  WGSGKDTSDVEPTAPMEEPTVVEESQGTPEEESPAKVPELEVEEETQVQEMTLDEWKNLQ
  EQTRPKPEFNIRKPESTVPSKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEIN
  FGNLPRPGRGARGGTRGGRGRIRRAENYGPRAEVVMQDVAPNPDDPEDFPALS

• Sequence length: 413

Pathways

Reactome Pathway:

Platelet degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Hepatocellular carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	28695742		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33775245	Inhibit	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20551049	Associate	★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	28695742		★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin disease	Pubtator	28695742	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for HABP4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HABP4.