Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	132243
Gene name	H1.8 linker histone
Gene symbol	H1-8
Synonyms (NCBI Gene)	H1.8H1FOOH1ooosH1
Chromosome	3
Chromosome location	3q22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core hi

19 Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000786	Component	Nucleosome	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IBA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0006334	Process	Nucleosome assembly	IEA
GO:0030261	Process	Chromosome condensation	IBA
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0030527	Function	Structural constituent of chromatin	ISS
GO:0031492	Function	Nucleosomal DNA binding	IBA
GO:0031492	Function	Nucleosomal DNA binding	ISS
GO:0040029	Process	Epigenetic regulation of gene expression	ISS
GO:0045910	Process	Negative regulation of DNA recombination	IBA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8IZA3

Protein name

Histone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1)

Protein function

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type link

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00538	Linker_histone	52 → 128	linker histone H1 and H5 family	Domain

Tissue specificity

TISSUE SPECIFICITY: Oocyte-specific. {ECO:0000269|PubMed:12711322}.

Sequence

MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVL
EALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARG
ATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRP
AKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAGGLSRKAKA
KGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAKAPKAGQGPNTKAA
APAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA

Sequence length

346

Interactions

View interactions

Related Genes Genes most often co-reported with H1-8 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for H1-8.

Diseases Linked via Similar Genes Diseases curated for genes most similar to H1-8 (see Related Genes above), that are NOT already directly curated for H1-8 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to H1-8.

H1-8 (H1.8 linker histone)

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