GZMH (granzyme H)

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Gene Gene information from NCBI Gene database.
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Entrez ID 2999
Gene name Granzyme H
Gene symbol GZMH
Synonyms (NCBI Gene)
CCP-XCGL-2CSP-CCTLA1CTSGL2
Chromosome 14
Chromosome location 14q12
Summary This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protea
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
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GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity NAS 2193684, 2402757
GO:0005615 Component Extracellular space IBA
GO:0005764 Component Lysosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
116831 4710 ENSG00000100450
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P20718
Protein name Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C)
Protein function Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates
PDB 3TJU , 3TJV , 3TK9 , 4GAW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 21 → 239 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Constitutively expressed in NK cells. {ECO:0000269|PubMed:23269243}.
Sequence
Sequence length 246
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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Reactome Pathway
Metabolism of Angiotensinogen to Angiotensins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
CTSG 2 shared pathwaysRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Metabolism of Angiotensinogen to Angiotensins Related via 2 shared pathways including Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Metabolism of Angiotensinogen to Angiotensins.
Congenital heart disease Linked via 1 of 1 related geneCTSG Conotruncal cardiac defect Linked via 1 of 1 related geneCTSG