GRID2IP (Grid2 interacting protein)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 392862
• Gene name: Grid2 interacting protein
• Gene symbol: GRID2IP
• Synonyms (NCBI Gene): DELPHILIN
• Chromosome: 7
• Chromosome location: 7p22.1
• Summary: Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purk

miRNA Show/Hide all (37)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048784	hsa-miR-93-5p	CLASH	23622248
MIRT720909	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT720908	hsa-miR-663b	HITS-CLIP	19536157
MIRT720907	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT720906	hsa-miR-588	HITS-CLIP	19536157
MIRT720905	hsa-miR-2054	HITS-CLIP	19536157
MIRT720904	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT720909	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT720908	hsa-miR-663b	HITS-CLIP	19536157
MIRT720907	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT720906	hsa-miR-588	HITS-CLIP	19536157
MIRT720905	hsa-miR-2054	HITS-CLIP	19536157
MIRT720904	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT1034212	hsa-miR-1231	CLIP-seq
MIRT1034213	hsa-miR-1285	CLIP-seq
MIRT1034214	hsa-miR-1915	CLIP-seq
MIRT1034215	hsa-miR-3155	CLIP-seq
MIRT1034216	hsa-miR-3155b	CLIP-seq
MIRT1034217	hsa-miR-3187-5p	CLIP-seq
MIRT1034218	hsa-miR-34a	CLIP-seq
MIRT1034219	hsa-miR-34c-5p	CLIP-seq
MIRT1034220	hsa-miR-378g	CLIP-seq
MIRT1034221	hsa-miR-4286	CLIP-seq
MIRT1034222	hsa-miR-4486	CLIP-seq
MIRT1034223	hsa-miR-449a	CLIP-seq
MIRT1034224	hsa-miR-449b	CLIP-seq
MIRT1034225	hsa-miR-4726-3p	CLIP-seq
MIRT1034226	hsa-miR-484	CLIP-seq
MIRT1034227	hsa-miR-612	CLIP-seq
MIRT2006744	hsa-miR-1205	CLIP-seq
MIRT2239150	hsa-miR-1976	CLIP-seq
MIRT2239151	hsa-miR-370	CLIP-seq
MIRT2239152	hsa-miR-4268	CLIP-seq
MIRT2239153	hsa-miR-4448	CLIP-seq
MIRT2239154	hsa-miR-4774-5p	CLIP-seq
MIRT2239155	hsa-miR-591	CLIP-seq
MIRT2388758	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IEA
GO:0099092	Component	Postsynaptic density, intracellular component	IEA
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0150048	Component	Cerebellar granule cell to Purkinje cell synapse	IEA

Other IDs

• MIM: 610639
• HGNC: 18464
• e!Ensembl: ENSG00000215045

Protein

• UniProt ID: A4D2P6
• Protein name: Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)
• Protein function: Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	279 → 353	PDZ domain	Domain
  PF00595	PDZ	10 → 80	PDZ domain	Domain
  PF02181	FH2	820 → 1188	Formin Homology 2 Domain	Family

• Sequence:

  MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGL
  SRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRL
  AGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTL
  ALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPE
  RLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVW
  IESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFA
  SDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF
  QHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE
  LDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG
  TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW
  PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTR
  PPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFV
  TNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGP
  AQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVEN
  SEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKA
  YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRL
  SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL
  EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG
  FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ
  PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGL
  RSSGMVSPLAW

• Sequence length: 1211

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CROHN'S DISEASE	—	GWAS catalog	28067908	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	28067908	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	36411363	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary degenerative dementia of the Alzheimer type, presenile onset	Uncertain significance	ClinVar Disgenet	—	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ULCERATIVE COLITIS	—	GWAS catalog	28067908	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37964339	Associate	★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	31836585	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	28067908		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for GRID2IP.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GRID2IP.