GRAMD1A (GRAM domain containing 1A)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57655
• Gene name: GRAM domain containing 1A
• Gene symbol: GRAMD1A
• Synonyms (NCBI Gene): KIAA1533
• Chromosome: 19
• Chromosome location: 19q13.11

miRNA Show/Hide all (32)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020153	hsa-miR-130b-3p	Sequencing	20371350
MIRT025741	hsa-miR-7-5p	Microarray	19073608
MIRT028025	hsa-miR-93-5p	Sequencing	20371350
MIRT081985	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT081981	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT081985	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT081980	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT081987	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028025	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT081991	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT081981	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1032741	hsa-miR-106a	CLIP-seq
MIRT1032742	hsa-miR-106b	CLIP-seq
MIRT1032743	hsa-miR-17	CLIP-seq
MIRT1032744	hsa-miR-20a	CLIP-seq
MIRT1032745	hsa-miR-20b	CLIP-seq
MIRT1032746	hsa-miR-3609	CLIP-seq
MIRT1032747	hsa-miR-3663-5p	CLIP-seq
MIRT1032748	hsa-miR-4260	CLIP-seq
MIRT1032749	hsa-miR-4292	CLIP-seq
MIRT1032750	hsa-miR-4308	CLIP-seq
MIRT1032751	hsa-miR-4509	CLIP-seq
MIRT1032752	hsa-miR-4744	CLIP-seq
MIRT1032753	hsa-miR-4796-3p	CLIP-seq
MIRT1032754	hsa-miR-486-3p	CLIP-seq
MIRT1032755	hsa-miR-519a	CLIP-seq
MIRT1032756	hsa-miR-519b-3p	CLIP-seq
MIRT1032757	hsa-miR-519c-3p	CLIP-seq
MIRT1032758	hsa-miR-519d	CLIP-seq
MIRT1032759	hsa-miR-548ah	CLIP-seq
MIRT1032760	hsa-miR-601	CLIP-seq
MIRT1032761	hsa-miR-93	CLIP-seq

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005776	Component	Autophagosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	29469807
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	29469807
GO:0005886	Component	Plasma membrane	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006914	Process	Autophagy	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0015485	Function	Cholesterol binding	IBA
GO:0015485	Function	Cholesterol binding	IEA
GO:0015485	Function	Cholesterol binding	ISS
GO:0016020	Component	Membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032366	Process	Intracellular sterol transport	IBA
GO:0044232	Component	Organelle membrane contact site	IDA	29469807
GO:0044232	Component	Organelle membrane contact site	IEA
GO:0071397	Process	Cellular response to cholesterol	IEA
GO:0071397	Process	Cellular response to cholesterol	ISS
GO:0120020	Function	Cholesterol transfer activity	IBA
GO:0120020	Function	Cholesterol transfer activity	IEA
GO:0120020	Function	Cholesterol transfer activity	ISS
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	IBA
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	IEA
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	ISS

Other IDs

• MIM: 620178
• HGNC: 29305
• e!Ensembl: ENSG00000089351

Protein

• UniProt ID: Q96CP6
• Protein name: Protein Aster-A (GRAM domain-containing protein 1A)
• Protein function: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02893	GRAM	91 → 200	GRAM domain	Domain
  PF16016	VASt	370 → 518	VAD1 Analog of StAR-related lipid transfer domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver. {ECO:0000269|PubMed:27585821}.
• Sequence:

  MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPST
  QSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILL
  QGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTS
  FGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLG
  TPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVD
  SQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLA
  ALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQR
  RVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYC
  ILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEE
  GGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGP
  GAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTA
  TEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPD
  DSFS

• Sequence length: 724

Related Genes

No strongly related genes found yet for GRAMD1A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GRAMD1A.