Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	2828
Gene name	G protein-coupled receptor 4
Gene symbol	GPR4
Synonyms (NCBI Gene)	GPR6C.lhGPR4
Chromosome	19
Chromosome location	19q13.32

158 Show/Hide all (158)

miRTarBase ID	miRNA	Experiments
MIRT1031408	hsa-miR-10a	CLIP-seq
MIRT1031409	hsa-miR-10b	CLIP-seq
MIRT1031410	hsa-miR-1225-3p	CLIP-seq
MIRT1031411	hsa-miR-1233	CLIP-seq
MIRT1031412	hsa-miR-128	CLIP-seq
MIRT1031413	hsa-miR-1285	CLIP-seq
MIRT1031414	hsa-miR-129-3p	CLIP-seq
MIRT1031415	hsa-miR-153	CLIP-seq
MIRT1031416	hsa-miR-185	CLIP-seq
MIRT1031417	hsa-miR-217	CLIP-seq
MIRT1031418	hsa-miR-299-3p	CLIP-seq
MIRT1031419	hsa-miR-3122	CLIP-seq
MIRT1031420	hsa-miR-3153	CLIP-seq
MIRT1031421	hsa-miR-3187-5p	CLIP-seq
MIRT1031422	hsa-miR-3200-5p	CLIP-seq
MIRT1031423	hsa-miR-339-5p	CLIP-seq
MIRT1031424	hsa-miR-3612	CLIP-seq
MIRT1031425	hsa-miR-3613-3p	CLIP-seq
MIRT1031426	hsa-miR-3663-3p	CLIP-seq
MIRT1031427	hsa-miR-3675-3p	CLIP-seq
MIRT1031428	hsa-miR-3689a-3p	CLIP-seq
MIRT1031429	hsa-miR-3689c	CLIP-seq
MIRT1031430	hsa-miR-3689d	CLIP-seq
MIRT1031431	hsa-miR-3714	CLIP-seq
MIRT1031432	hsa-miR-3913-5p	CLIP-seq
MIRT1031433	hsa-miR-3929	CLIP-seq
MIRT1031434	hsa-miR-4261	CLIP-seq
MIRT1031435	hsa-miR-4303	CLIP-seq
MIRT1031436	hsa-miR-4306	CLIP-seq
MIRT1031437	hsa-miR-4418	CLIP-seq
MIRT1031438	hsa-miR-4419b	CLIP-seq
MIRT1031439	hsa-miR-4421	CLIP-seq
MIRT1031440	hsa-miR-4433	CLIP-seq
MIRT1031441	hsa-miR-4443	CLIP-seq
MIRT1031442	hsa-miR-4459	CLIP-seq
MIRT1031443	hsa-miR-4478	CLIP-seq
MIRT1031444	hsa-miR-448	CLIP-seq
MIRT1031445	hsa-miR-4644	CLIP-seq
MIRT1031446	hsa-miR-4646-5p	CLIP-seq
MIRT1031447	hsa-miR-4648	CLIP-seq
MIRT1031448	hsa-miR-4654	CLIP-seq
MIRT1031449	hsa-miR-4666-3p	CLIP-seq
MIRT1031450	hsa-miR-4668-5p	CLIP-seq
MIRT1031451	hsa-miR-4722-5p	CLIP-seq
MIRT1031452	hsa-miR-4725-5p	CLIP-seq
MIRT1031453	hsa-miR-4728-5p	CLIP-seq
MIRT1031454	hsa-miR-4747-5p	CLIP-seq
MIRT1031455	hsa-miR-4769-5p	CLIP-seq
MIRT1031456	hsa-miR-4786-5p	CLIP-seq
MIRT1031457	hsa-miR-4793-3p	CLIP-seq
MIRT1031458	hsa-miR-485-5p	CLIP-seq
MIRT1031459	hsa-miR-494	CLIP-seq
MIRT1031460	hsa-miR-504	CLIP-seq
MIRT1031461	hsa-miR-508-5p	CLIP-seq
MIRT1031462	hsa-miR-509-3-5p	CLIP-seq
MIRT1031463	hsa-miR-509-5p	CLIP-seq
MIRT1031464	hsa-miR-515-5p	CLIP-seq
MIRT1031465	hsa-miR-526b	CLIP-seq
MIRT1031466	hsa-miR-587	CLIP-seq
MIRT1031467	hsa-miR-612	CLIP-seq
MIRT1031468	hsa-miR-650	CLIP-seq
MIRT1031469	hsa-miR-661	CLIP-seq
MIRT1031470	hsa-miR-665	CLIP-seq
MIRT1031471	hsa-miR-766	CLIP-seq
MIRT1031472	hsa-miR-769-5p	CLIP-seq
MIRT1031473	hsa-miR-940	CLIP-seq
MIRT1549364	hsa-miR-450b-5p	CLIP-seq
MIRT1549365	hsa-miR-4803	CLIP-seq
MIRT1549366	hsa-miR-518a-5p	CLIP-seq
MIRT1549367	hsa-miR-527	CLIP-seq
MIRT1031410	hsa-miR-1225-3p	CLIP-seq
MIRT1031411	hsa-miR-1233	CLIP-seq
MIRT1031420	hsa-miR-3153	CLIP-seq
MIRT1031431	hsa-miR-3714	CLIP-seq
MIRT1031434	hsa-miR-4261	CLIP-seq
MIRT1031440	hsa-miR-4433	CLIP-seq
MIRT1031442	hsa-miR-4459	CLIP-seq
MIRT1549364	hsa-miR-450b-5p	CLIP-seq
MIRT1031446	hsa-miR-4646-5p	CLIP-seq
MIRT1031450	hsa-miR-4668-5p	CLIP-seq
MIRT1031451	hsa-miR-4722-5p	CLIP-seq
MIRT1549365	hsa-miR-4803	CLIP-seq
MIRT1031459	hsa-miR-494	CLIP-seq
MIRT1549366	hsa-miR-518a-5p	CLIP-seq
MIRT1031465	hsa-miR-526b	CLIP-seq
MIRT1549367	hsa-miR-527	CLIP-seq
MIRT1031469	hsa-miR-661	CLIP-seq
MIRT1031470	hsa-miR-665	CLIP-seq
MIRT1031473	hsa-miR-940	CLIP-seq
MIRT1031412	hsa-miR-128	CLIP-seq
MIRT1031413	hsa-miR-1285	CLIP-seq
MIRT1031417	hsa-miR-217	CLIP-seq
MIRT1031418	hsa-miR-299-3p	CLIP-seq
MIRT1031419	hsa-miR-3122	CLIP-seq
MIRT1031421	hsa-miR-3187-5p	CLIP-seq
MIRT1031424	hsa-miR-3612	CLIP-seq
MIRT1031426	hsa-miR-3663-3p	CLIP-seq
MIRT1031428	hsa-miR-3689a-3p	CLIP-seq
MIRT1031429	hsa-miR-3689c	CLIP-seq
MIRT1031430	hsa-miR-3689d	CLIP-seq
MIRT1031431	hsa-miR-3714	CLIP-seq
MIRT1031432	hsa-miR-3913-5p	CLIP-seq
MIRT1031433	hsa-miR-3929	CLIP-seq
MIRT2238538	hsa-miR-4281	CLIP-seq
MIRT1031437	hsa-miR-4418	CLIP-seq
MIRT1031438	hsa-miR-4419b	CLIP-seq
MIRT1031441	hsa-miR-4443	CLIP-seq
MIRT1031442	hsa-miR-4459	CLIP-seq
MIRT1031443	hsa-miR-4478	CLIP-seq
MIRT1031447	hsa-miR-4648	CLIP-seq
MIRT1031448	hsa-miR-4654	CLIP-seq
MIRT1031451	hsa-miR-4722-5p	CLIP-seq
MIRT1031453	hsa-miR-4728-5p	CLIP-seq
MIRT1031455	hsa-miR-4769-5p	CLIP-seq
MIRT1031456	hsa-miR-4786-5p	CLIP-seq
MIRT1031457	hsa-miR-4793-3p	CLIP-seq
MIRT1031458	hsa-miR-485-5p	CLIP-seq
MIRT1031461	hsa-miR-508-5p	CLIP-seq
MIRT1031462	hsa-miR-509-3-5p	CLIP-seq
MIRT1031463	hsa-miR-509-5p	CLIP-seq
MIRT1031467	hsa-miR-612	CLIP-seq
MIRT1031468	hsa-miR-650	CLIP-seq
MIRT1031469	hsa-miR-661	CLIP-seq
MIRT1031470	hsa-miR-665	CLIP-seq
MIRT1031471	hsa-miR-766	CLIP-seq
MIRT1031472	hsa-miR-769-5p	CLIP-seq
MIRT1031473	hsa-miR-940	CLIP-seq
MIRT1031408	hsa-miR-10a	CLIP-seq
MIRT1031409	hsa-miR-10b	CLIP-seq
MIRT1031410	hsa-miR-1225-3p	CLIP-seq
MIRT1031411	hsa-miR-1233	CLIP-seq
MIRT1031412	hsa-miR-128	CLIP-seq
MIRT1031423	hsa-miR-339-5p	CLIP-seq
MIRT1031425	hsa-miR-3613-3p	CLIP-seq
MIRT1031431	hsa-miR-3714	CLIP-seq
MIRT1031439	hsa-miR-4421	CLIP-seq
MIRT1031440	hsa-miR-4433	CLIP-seq
MIRT1031442	hsa-miR-4459	CLIP-seq
MIRT1031451	hsa-miR-4722-5p	CLIP-seq
MIRT1031452	hsa-miR-4725-5p	CLIP-seq
MIRT1031456	hsa-miR-4786-5p	CLIP-seq
MIRT1031460	hsa-miR-504	CLIP-seq
MIRT1031464	hsa-miR-515-5p	CLIP-seq
MIRT1031465	hsa-miR-526b	CLIP-seq
MIRT1031470	hsa-miR-665	CLIP-seq
MIRT1031472	hsa-miR-769-5p	CLIP-seq
MIRT1031473	hsa-miR-940	CLIP-seq
MIRT1031408	hsa-miR-10a	CLIP-seq
MIRT1031409	hsa-miR-10b	CLIP-seq
MIRT1031412	hsa-miR-128	CLIP-seq
MIRT1031423	hsa-miR-339-5p	CLIP-seq
MIRT1031425	hsa-miR-3613-3p	CLIP-seq
MIRT1031439	hsa-miR-4421	CLIP-seq
MIRT1031452	hsa-miR-4725-5p	CLIP-seq
MIRT1031456	hsa-miR-4786-5p	CLIP-seq
MIRT1031460	hsa-miR-504	CLIP-seq
MIRT1031464	hsa-miR-515-5p	CLIP-seq
MIRT1031472	hsa-miR-769-5p	CLIP-seq

36 Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	39753132, 39799123
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IMP	20211729
GO:0004930	Function	G protein-coupled receptor activity	TAS	7498459
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17462861
GO:0005886	Component	Plasma membrane	IDA	20211729
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8595909
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	7498459
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17110384, 39884271
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17462861, 22110680, 39753132, 39799123
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	12955148, 20211729
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	20211729
GO:0010447	Process	Response to acidic pH	IDA	17462861, 22110680
GO:0010447	Process	Response to acidic pH	IEA
GO:0010447	Process	Response to acidic pH	IMP	12955148
GO:0016020	Component	Membrane	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IEA
GO:0030155	Process	Regulation of cell adhesion	IDA	22110680
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IDA	17462861
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IMP	20211729
GO:0043114	Process	Regulation of vascular permeability	IEA
GO:0043114	Process	Regulation of vascular permeability	ISS
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0050729	Process	Positive regulation of inflammatory response	ISS
GO:0060055	Process	Angiogenesis involved in wound healing	IEA
GO:0071468	Process	Cellular response to acidic pH	IDA	39753132, 39799123
GO:0071468	Process	Cellular response to acidic pH	IEA
GO:0072144	Process	Glomerular mesangial cell development	IEA

MIM	HGNC	e!Ensembl
600551	4497	ENSG00000177464

P46093

Protein name

G-prodeshotein coupled receptor 4 (hGPR4) (G-protein coupled receptor 6C.l) (GPR6C.l)

Protein function

Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:17462861, PubMed:33478938, PubMed:39753132, PubMed:39799123). Activated by

PDB

9BIP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	34 → 286	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLS
IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVA
HPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAW
MNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPY
HVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKA
LHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPP
AQ

Sequence length

362

Interactions

View interactions

Reactome Pathway
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events

GPR4 (G protein-coupled receptor 4)

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