GPR3 (G protein-coupled receptor 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2827
• Gene name: G protein-coupled receptor 3
• Gene symbol: GPR3
• Synonyms (NCBI Gene): ACCA
• Chromosome: 1
• Chromosome location: 1p36.11
• Summary: This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intrace

miRNA Show/Hide all (53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1031281	hsa-miR-106a	CLIP-seq
MIRT1031282	hsa-miR-106b	CLIP-seq
MIRT1031283	hsa-miR-1207-3p	CLIP-seq
MIRT1031284	hsa-miR-1275	CLIP-seq
MIRT1031285	hsa-miR-1299	CLIP-seq
MIRT1031286	hsa-miR-151-5p	CLIP-seq
MIRT1031287	hsa-miR-151b	CLIP-seq
MIRT1031288	hsa-miR-1587	CLIP-seq
MIRT1031289	hsa-miR-17	CLIP-seq
MIRT1031290	hsa-miR-1972	CLIP-seq
MIRT1031291	hsa-miR-20a	CLIP-seq
MIRT1031292	hsa-miR-20b	CLIP-seq
MIRT1031293	hsa-miR-3127-3p	CLIP-seq
MIRT1031294	hsa-miR-328	CLIP-seq
MIRT1031295	hsa-miR-3609	CLIP-seq
MIRT1031296	hsa-miR-361-3p	CLIP-seq
MIRT1031297	hsa-miR-3616-3p	CLIP-seq
MIRT1031298	hsa-miR-3622a-3p	CLIP-seq
MIRT1031299	hsa-miR-3622b-3p	CLIP-seq
MIRT1031300	hsa-miR-378g	CLIP-seq
MIRT1031301	hsa-miR-3974	CLIP-seq
MIRT1031302	hsa-miR-4260	CLIP-seq
MIRT1031303	hsa-miR-4436b-3p	CLIP-seq
MIRT1031304	hsa-miR-4492	CLIP-seq
MIRT1031305	hsa-miR-4498	CLIP-seq
MIRT1031306	hsa-miR-4522	CLIP-seq
MIRT1031307	hsa-miR-4656	CLIP-seq
MIRT1031308	hsa-miR-4665-5p	CLIP-seq
MIRT1031309	hsa-miR-4675	CLIP-seq
MIRT1031310	hsa-miR-4677-3p	CLIP-seq
MIRT1031311	hsa-miR-4687-3p	CLIP-seq
MIRT1031312	hsa-miR-4741	CLIP-seq
MIRT1031313	hsa-miR-4761-5p	CLIP-seq
MIRT1031314	hsa-miR-4779	CLIP-seq
MIRT1031315	hsa-miR-4782-5p	CLIP-seq
MIRT1031316	hsa-miR-4796-3p	CLIP-seq
MIRT1031317	hsa-miR-516b	CLIP-seq
MIRT1031318	hsa-miR-519d	CLIP-seq
MIRT1031319	hsa-miR-543	CLIP-seq
MIRT1031320	hsa-miR-548ah	CLIP-seq
MIRT1031321	hsa-miR-762	CLIP-seq
MIRT1031322	hsa-miR-875-3p	CLIP-seq
MIRT1031323	hsa-miR-93	CLIP-seq
MIRT2005931	hsa-miR-3620	CLIP-seq
MIRT2005932	hsa-miR-3679-3p	CLIP-seq
MIRT2005933	hsa-miR-5096	CLIP-seq
MIRT2388663	hsa-miR-3149	CLIP-seq
MIRT2388664	hsa-miR-410	CLIP-seq
MIRT2388665	hsa-miR-448	CLIP-seq
MIRT2388666	hsa-miR-455-5p	CLIP-seq
MIRT2388667	hsa-miR-568	CLIP-seq
MIRT2682049	hsa-miR-3179	CLIP-seq
MIRT2682050	hsa-miR-4475	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	7639700
GO:0005515	Function	Protein binding	IPI	24069330
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7639700
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS	7639700
GO:0016020	Component	Membrane	IEA
GO:0038036	Function	Sphingosine-1-phosphate receptor activity	IBA
GO:0040020	Process	Regulation of meiotic nuclear division	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	26455425

Other IDs

• MIM: 600241
• HGNC: 4484
• e!Ensembl: ENSG00000181773

Protein

• UniProt ID: P46089
• Protein name: G-protein coupled receptor 3 (ACCA orphan receptor)
• Protein function: Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numer
• PDB: 8U8F , 8WW2 , 8X2K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	57 → 297	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
• Sequence:

  MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENAL
  VVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAF
  TASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDG
  LTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYV
  ATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFR
  NQDVQKVLWAVCCCCSSSKIPFRSRSPSDV

• Sequence length: 330

Related Genes

No strongly related genes found yet for GPR3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GPR3.