GPR21 (G protein-coupled receptor 21)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2844
• Gene name: G protein-coupled receptor 21
• Gene symbol: GPR21
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q33.2
• Summary: This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathwa

miRNA Show/Hide all (63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT628669	hsa-miR-8485	HITS-CLIP	22927820
MIRT706250	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT706249	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT706248	hsa-miR-603	HITS-CLIP	22927820
MIRT706247	hsa-miR-577	HITS-CLIP	22927820
MIRT706245	hsa-miR-3163	HITS-CLIP	22927820
MIRT706246	hsa-miR-3941	HITS-CLIP	22927820
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	27418678
MIRT628669	hsa-miR-8485	HITS-CLIP	22927820
MIRT706250	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT706249	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT706248	hsa-miR-603	HITS-CLIP	22927820
MIRT706247	hsa-miR-577	HITS-CLIP	22927820
MIRT706245	hsa-miR-3163	HITS-CLIP	22927820
MIRT706246	hsa-miR-3941	HITS-CLIP	22927820
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327
MIRT628669	hsa-miR-8485	HITS-CLIP	23824327
MIRT628668	hsa-miR-602	HITS-CLIP	23824327
MIRT628667	hsa-miR-4681	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0040018	Process	Positive regulation of multicellular organism growth	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA

Other IDs

• MIM: 601909
• HGNC: 4476
• e!Ensembl: ENSG00000188394

Protein

• UniProt ID: Q99679
• Protein name: Probable G-protein coupled receptor 21
• Protein function: Orphan receptor.
• PDB: 8HIX , 8HJ0 , 8HJ1 , 8HJ2 , 8HMV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	45 → 304	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.
• Sequence:

  MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
  HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
  ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
  CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
  EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
  CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI

• Sequence length: 349

Related Genes

No strongly related genes found yet for GPR21.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GPR21.