GPR146 (G protein-coupled receptor 146)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 115330
• Gene name: G protein-coupled receptor 146
• Gene symbol: GPR146
• Synonyms (NCBI Gene): PGR8
• Chromosome: 7
• Chromosome location: 7p22.3

miRNA Show/Hide all (49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT723975	hsa-miR-4530	HITS-CLIP	19536157
MIRT723974	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT723973	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT723972	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT723971	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT723970	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT723969	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT723968	hsa-miR-1976	HITS-CLIP	19536157
MIRT723967	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT723966	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT723965	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT723964	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT723963	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT723962	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT723961	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT723960	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT723975	hsa-miR-4530	HITS-CLIP	19536157
MIRT723974	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT723973	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT723972	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT723971	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT723970	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT723969	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT723968	hsa-miR-1976	HITS-CLIP	19536157
MIRT723967	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT723966	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT723965	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT723964	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT723963	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT723962	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT723961	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT723960	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT1030571	hsa-miR-1297	CLIP-seq
MIRT1030572	hsa-miR-26a	CLIP-seq
MIRT1030573	hsa-miR-26b	CLIP-seq
MIRT1030574	hsa-miR-3148	CLIP-seq
MIRT1030575	hsa-miR-3153	CLIP-seq
MIRT1030576	hsa-miR-4465	CLIP-seq
MIRT1030577	hsa-miR-4496	CLIP-seq
MIRT1030578	hsa-miR-4668-5p	CLIP-seq
MIRT1030579	hsa-miR-4716-3p	CLIP-seq
MIRT1030580	hsa-miR-495	CLIP-seq
MIRT1030581	hsa-miR-625	CLIP-seq
MIRT2005769	hsa-miR-3175	CLIP-seq
MIRT2005770	hsa-miR-4650-5p	CLIP-seq
MIRT1030579	hsa-miR-4716-3p	CLIP-seq
MIRT1030580	hsa-miR-495	CLIP-seq
MIRT2005771	hsa-miR-542-5p	CLIP-seq
MIRT1030581	hsa-miR-625	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IDA	38503280
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IDA	38503280
GO:0005886	Component	Plasma membrane	IDA	23759446
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	38503280
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	38503280
GO:0009615	Process	Response to virus	IEA
GO:0016020	Component	Membrane	IEA
GO:0034341	Process	Response to type II interferon	IEA
GO:0035456	Process	Response to interferon-beta	IEA
GO:0045540	Process	Regulation of cholesterol biosynthetic process	IDA	38503280
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IDA	38503280
GO:0051607	Process	Defense response to virus	IEA

Other IDs

• MIM: 621173
• HGNC: 21718
• e!Ensembl: ENSG00000164849

Protein

• UniProt ID: Q96CH1
• Protein name: G-protein coupled receptor 146 (G-protein coupled receptor PGR8)
• Protein function: G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	44 → 296	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMT
  MPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYST
  ALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAK
  MQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVC
  TQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMN
  QSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA

• Sequence length: 333

Related Genes

No strongly related genes found yet for GPR146.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GPR146.