Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 2814
Gene name Glycoprotein V platelet
Gene symbol GP5
Synonyms (NCBI Gene)
CD42dGPV
Chromosome 3
Chromosome location 3q29
Summary Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circul
miRNA miRNA information provided by mirtarbase database.
250 Show/Hide all (250)
miRTarBase ID miRNA Experiments Reference
MIRT052370 hsa-let-7a-5p CLASH 23622248
MIRT691380 hsa-miR-3614-5p HITS-CLIP 23313552
MIRT691379 hsa-miR-6500-3p HITS-CLIP 23313552
MIRT691378 hsa-miR-1288-5p HITS-CLIP 23313552
MIRT691377 hsa-miR-383-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 1730602
GO:0005886 Component Plasma membrane TAS 7690959, 10429193
GO:0007155 Process Cell adhesion IEA
GO:0007155 Process Cell adhesion NAS 7690959
GO:0007596 Process Blood coagulation IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
173511 4443 ENSG00000178732
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P40197
Protein name Platelet glycoprotein V (GPV) (Glycoprotein 5) (CD antigen CD42d)
Protein function The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 74 → 134 Leucine rich repeat Repeat
PF13855 LRR_8 194 → 254 Leucine rich repeat Repeat
PF13855 LRR_8 98 → 158 Leucine rich repeat Repeat
PF13855 LRR_8 364 → 422 Leucine rich repeat Repeat
PF13855 LRR_8 124 → 182 Leucine rich repeat Repeat
PF13855 LRR_8 146 → 192 Leucine rich repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Platelets and megakaryocytes.
Sequence
MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGM
GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK
MVL
LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN
NL
THLPKGLLGA
QAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR
LPNLSSLTLSRNHL
AFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT
QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR
GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH
NS
WRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPPP
RPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVIIV
FAMIKIGQLFRKLIRERALG
Sequence length 560
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
ECM-receptor interaction Intrinsic Pathway of Fibrin Clot Formation
Platelet activation GP1b-IX-V activation signalling
Hematopoietic cell lineage Platelet Adhesion to exposed collagen
  Platelet Aggregation (Plug Formation)