Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circul
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Platelet glycoprotein V (GPV) (Glycoprotein 5) (CD antigen CD42d)
Protein function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
["ECM-receptor interaction","Platelet activation","GP1b-IX-V activation signalling","Platelet Adhesion to exposed collagen","Platelet Aggregation (Plug Formation)","Intrinsic Pathway of Fibrin Clot Formation"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to GP5 (see Related Genes above), that are NOT already directly curated for GP5 itself -- a lead worth checking, not a confirmed association.