GMEB2 (glucocorticoid modulatory element binding protein 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26205
• Gene name: Glucocorticoid modulatory element binding protein 2
• Gene symbol: GMEB2
• Synonyms (NCBI Gene): GMEB-2, P79PIF, PIF79
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the g

miRNA Show/Hide all (198)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019657	hsa-miR-378a-3p	Sequencing	20371350
MIRT027243	hsa-miR-101-3p	Sequencing	20371350
MIRT031159	hsa-miR-19b-3p	Sequencing	20371350
MIRT043805	hsa-miR-328-3p	CLASH	23622248
MIRT036954	hsa-miR-877-3p	CLASH	23622248
MIRT738514	hsa-miR-4437	HITS-CLIP	33718276
MIRT738516	hsa-miR-378g	HITS-CLIP	33718276
MIRT738518	hsa-miR-612	HITS-CLIP	33718276
MIRT738522	hsa-miR-330-5p	HITS-CLIP	33718276
MIRT738525	hsa-miR-3155b	HITS-CLIP	33718276
MIRT1022499	hsa-miR-1254	CLIP-seq
MIRT1022500	hsa-miR-1266	CLIP-seq
MIRT1022501	hsa-miR-144	CLIP-seq
MIRT1022502	hsa-miR-19a	CLIP-seq
MIRT1022503	hsa-miR-19b	CLIP-seq
MIRT1022504	hsa-miR-30a	CLIP-seq
MIRT1022505	hsa-miR-30b	CLIP-seq
MIRT1022506	hsa-miR-30c	CLIP-seq
MIRT1022507	hsa-miR-30d	CLIP-seq
MIRT1022508	hsa-miR-30e	CLIP-seq
MIRT1022509	hsa-miR-3116	CLIP-seq
MIRT1022510	hsa-miR-3136-3p	CLIP-seq
MIRT1022511	hsa-miR-3148	CLIP-seq
MIRT1022512	hsa-miR-3619-3p	CLIP-seq
MIRT1022513	hsa-miR-3664-3p	CLIP-seq
MIRT1022514	hsa-miR-3688-3p	CLIP-seq
MIRT1022515	hsa-miR-3690	CLIP-seq
MIRT1022516	hsa-miR-3922-5p	CLIP-seq
MIRT1022517	hsa-miR-4283	CLIP-seq
MIRT1022518	hsa-miR-4436a	CLIP-seq
MIRT1022519	hsa-miR-4518	CLIP-seq
MIRT1022520	hsa-miR-4666-5p	CLIP-seq
MIRT1022521	hsa-miR-4691-3p	CLIP-seq
MIRT1022522	hsa-miR-4776-5p	CLIP-seq
MIRT1022523	hsa-miR-4797-3p	CLIP-seq
MIRT1022524	hsa-miR-513a-5p	CLIP-seq
MIRT1022525	hsa-miR-519a	CLIP-seq
MIRT1022526	hsa-miR-519b-3p	CLIP-seq
MIRT1022527	hsa-miR-519c-3p	CLIP-seq
MIRT1022528	hsa-miR-548ac	CLIP-seq
MIRT1022529	hsa-miR-548ae	CLIP-seq
MIRT1022530	hsa-miR-548aj	CLIP-seq
MIRT1022531	hsa-miR-548am	CLIP-seq
MIRT1022532	hsa-miR-548d-3p	CLIP-seq
MIRT1022533	hsa-miR-548x	CLIP-seq
MIRT1022534	hsa-miR-548z	CLIP-seq
MIRT1022535	hsa-miR-661	CLIP-seq
MIRT1022499	hsa-miR-1254	CLIP-seq
MIRT738519	hsa-miR-1285	CLIP-seq
MIRT2002964	hsa-miR-1913	CLIP-seq
MIRT2002965	hsa-miR-1915	CLIP-seq
MIRT1022502	hsa-miR-19a	CLIP-seq
MIRT1022503	hsa-miR-19b	CLIP-seq
MIRT1022509	hsa-miR-3116	CLIP-seq
MIRT2002966	hsa-miR-3120-3p	CLIP-seq
MIRT2002967	hsa-miR-3166	CLIP-seq
MIRT738517	hsa-miR-3187-5p	CLIP-seq
MIRT2002968	hsa-miR-3189-5p	CLIP-seq
MIRT2002969	hsa-miR-324-3p	CLIP-seq
MIRT2002970	hsa-miR-4269	CLIP-seq
MIRT2002971	hsa-miR-4270	CLIP-seq
MIRT2002972	hsa-miR-4303	CLIP-seq
MIRT2002973	hsa-miR-4441	CLIP-seq
MIRT2002974	hsa-miR-4456	CLIP-seq
MIRT738520	hsa-miR-4486	CLIP-seq
MIRT2002975	hsa-miR-4504	CLIP-seq
MIRT2002976	hsa-miR-4505	CLIP-seq
MIRT2002977	hsa-miR-4514	CLIP-seq
MIRT2002978	hsa-miR-4633-5p	CLIP-seq
MIRT1022520	hsa-miR-4666-5p	CLIP-seq
MIRT2002979	hsa-miR-4692	CLIP-seq
MIRT2002980	hsa-miR-4758-3p	CLIP-seq
MIRT2002981	hsa-miR-4771	CLIP-seq
MIRT1022523	hsa-miR-4797-3p	CLIP-seq
MIRT2002982	hsa-miR-499-3p	CLIP-seq
MIRT2002983	hsa-miR-499a-3p	CLIP-seq
MIRT2002984	hsa-miR-532-5p	CLIP-seq
MIRT2002985	hsa-miR-542-3p	CLIP-seq
MIRT2002986	hsa-miR-545	CLIP-seq
MIRT1022528	hsa-miR-548ac	CLIP-seq
MIRT1022529	hsa-miR-548ae	CLIP-seq
MIRT1022530	hsa-miR-548aj	CLIP-seq
MIRT1022531	hsa-miR-548am	CLIP-seq
MIRT1022532	hsa-miR-548d-3p	CLIP-seq
MIRT1022533	hsa-miR-548x	CLIP-seq
MIRT1022534	hsa-miR-548z	CLIP-seq
MIRT2002987	hsa-miR-549	CLIP-seq
MIRT738523	hsa-miR-760	CLIP-seq
MIRT2002988	hsa-miR-943	CLIP-seq
MIRT2236065	hsa-miR-1224-3p	CLIP-seq
MIRT2236066	hsa-miR-1228	CLIP-seq
MIRT2236067	hsa-miR-1262	CLIP-seq
MIRT1022500	hsa-miR-1266	CLIP-seq
MIRT2236068	hsa-miR-149	CLIP-seq
MIRT2236069	hsa-miR-150	CLIP-seq
MIRT2236070	hsa-miR-1587	CLIP-seq
MIRT2236071	hsa-miR-199a-3p	CLIP-seq
MIRT2236072	hsa-miR-199b-3p	CLIP-seq
MIRT2236073	hsa-miR-3129-5p	CLIP-seq
MIRT2236074	hsa-miR-3130-3p	CLIP-seq
MIRT2236075	hsa-miR-3135	CLIP-seq
MIRT738524	hsa-miR-3155	CLIP-seq
MIRT2236076	hsa-miR-329	CLIP-seq
MIRT2236077	hsa-miR-3616-3p	CLIP-seq
MIRT2236078	hsa-miR-3622a-3p	CLIP-seq
MIRT2236079	hsa-miR-3622a-5p	CLIP-seq
MIRT2236080	hsa-miR-3622b-3p	CLIP-seq
MIRT2236081	hsa-miR-362-3p	CLIP-seq
MIRT2236082	hsa-miR-3647-3p	CLIP-seq
MIRT2236083	hsa-miR-3649	CLIP-seq
MIRT2236084	hsa-miR-3663-3p	CLIP-seq
MIRT2236085	hsa-miR-3691-3p	CLIP-seq
MIRT2236086	hsa-miR-3919	CLIP-seq
MIRT2236087	hsa-miR-3921	CLIP-seq
MIRT1022516	hsa-miR-3922-5p	CLIP-seq
MIRT2236088	hsa-miR-3943	CLIP-seq
MIRT2002970	hsa-miR-4269	CLIP-seq
MIRT2236089	hsa-miR-4292	CLIP-seq
MIRT2002972	hsa-miR-4303	CLIP-seq
MIRT2236090	hsa-miR-4323	CLIP-seq
MIRT2236091	hsa-miR-4330	CLIP-seq
MIRT2236092	hsa-miR-4423-3p	CLIP-seq
MIRT2236093	hsa-miR-4424	CLIP-seq
MIRT1022518	hsa-miR-4436a	CLIP-seq
MIRT2236094	hsa-miR-4436b-3p	CLIP-seq
MIRT2236095	hsa-miR-4453	CLIP-seq
MIRT2236096	hsa-miR-4468	CLIP-seq
MIRT2002975	hsa-miR-4504	CLIP-seq
MIRT2002976	hsa-miR-4505	CLIP-seq
MIRT1022519	hsa-miR-4518	CLIP-seq
MIRT2236097	hsa-miR-4538	CLIP-seq
MIRT2236098	hsa-miR-4640-5p	CLIP-seq
MIRT2236099	hsa-miR-4648	CLIP-seq
MIRT2236100	hsa-miR-4653-5p	CLIP-seq
MIRT1022520	hsa-miR-4666-5p	CLIP-seq
MIRT738515	hsa-miR-4674	CLIP-seq
MIRT2236101	hsa-miR-4690-5p	CLIP-seq
MIRT2236102	hsa-miR-4695-3p	CLIP-seq
MIRT2236103	hsa-miR-4701-3p	CLIP-seq
MIRT2236104	hsa-miR-4710	CLIP-seq
MIRT2236105	hsa-miR-4721	CLIP-seq
MIRT2236106	hsa-miR-4726-5p	CLIP-seq
MIRT1022523	hsa-miR-4797-3p	CLIP-seq
MIRT738526	hsa-miR-484	CLIP-seq
MIRT2236107	hsa-miR-489	CLIP-seq
MIRT2236108	hsa-miR-490-5p	CLIP-seq
MIRT1022524	hsa-miR-513a-5p	CLIP-seq
MIRT1022528	hsa-miR-548ac	CLIP-seq
MIRT1022529	hsa-miR-548ae	CLIP-seq
MIRT1022530	hsa-miR-548aj	CLIP-seq
MIRT1022531	hsa-miR-548am	CLIP-seq
MIRT1022532	hsa-miR-548d-3p	CLIP-seq
MIRT1022533	hsa-miR-548x	CLIP-seq
MIRT1022534	hsa-miR-548z	CLIP-seq
MIRT2236109	hsa-miR-563	CLIP-seq
MIRT2236110	hsa-miR-566	CLIP-seq
MIRT2236111	hsa-miR-635	CLIP-seq
MIRT2236112	hsa-miR-659	CLIP-seq
MIRT2236113	hsa-miR-802	CLIP-seq
MIRT2236114	hsa-miR-936	CLIP-seq
MIRT2002965	hsa-miR-1915	CLIP-seq
MIRT2539895	hsa-miR-1207-3p	CLIP-seq
MIRT2539896	hsa-miR-1225-3p	CLIP-seq
MIRT2236067	hsa-miR-1262	CLIP-seq
MIRT2539897	hsa-miR-3179	CLIP-seq
MIRT2236077	hsa-miR-3616-3p	CLIP-seq
MIRT2539898	hsa-miR-3940-5p	CLIP-seq
MIRT2236094	hsa-miR-4436b-3p	CLIP-seq
MIRT2539899	hsa-miR-4507	CLIP-seq
MIRT2539900	hsa-miR-4690-3p	CLIP-seq
MIRT2236103	hsa-miR-4701-3p	CLIP-seq
MIRT2236104	hsa-miR-4710	CLIP-seq
MIRT2236105	hsa-miR-4721	CLIP-seq
MIRT2539901	hsa-miR-4722-3p	CLIP-seq
MIRT2539902	hsa-miR-4730	CLIP-seq
MIRT2236107	hsa-miR-489	CLIP-seq
MIRT2539903	hsa-miR-646	CLIP-seq
MIRT2539895	hsa-miR-1207-3p	CLIP-seq
MIRT2539896	hsa-miR-1225-3p	CLIP-seq
MIRT2236067	hsa-miR-1262	CLIP-seq
MIRT738519	hsa-miR-1285	CLIP-seq
MIRT2681672	hsa-miR-2467-3p	CLIP-seq
MIRT738517	hsa-miR-3187-5p	CLIP-seq
MIRT2236077	hsa-miR-3616-3p	CLIP-seq
MIRT2539898	hsa-miR-3940-5p	CLIP-seq
MIRT2681673	hsa-miR-4257	CLIP-seq
MIRT2236094	hsa-miR-4436b-3p	CLIP-seq
MIRT738520	hsa-miR-4486	CLIP-seq
MIRT2539899	hsa-miR-4507	CLIP-seq
MIRT2236103	hsa-miR-4701-3p	CLIP-seq
MIRT2236104	hsa-miR-4710	CLIP-seq
MIRT2236105	hsa-miR-4721	CLIP-seq
MIRT2539901	hsa-miR-4722-3p	CLIP-seq
MIRT2539902	hsa-miR-4730	CLIP-seq
MIRT2236107	hsa-miR-489	CLIP-seq
MIRT2681674	hsa-miR-615-5p	CLIP-seq
MIRT2539903	hsa-miR-646	CLIP-seq
MIRT2681675	hsa-miR-652	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16713569, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	10523663
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	TAS	10523663
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 607451
• HGNC: 4371
• e!Ensembl: ENSG00000101216

Protein

• UniProt ID: Q9UKD1
• Protein name: Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79)
• Protein function: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promote
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01342	SAND	87 → 162	SAND domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.
• Sequence:

  MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAA
  AAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQY
  DEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKI
  DLSGARVSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDPGDWTAAIGDDTFTFWRGL
  KDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLAS
  HKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVSLPPPVKRPR
  LARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPLGKVVSTLPSTVLGKGSLQAPPA
  SSPASPLLGGYTVLASSGSTYPSTVEIHPDASSLTVLSTAAVQDGSTVFKVVSPLQLLTL
  PGLGPTLQNVAQASPGSSTIVTVPAGAAPGPEEHTATIEVAAMAEDHERK

• Sequence length: 530

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
IDIOPATHIC PULMONARY FIBROSIS	—	GWAS catalog	36777996	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	39792054	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	33398198, 34290314, 37340002, 37945903, 38632662	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	33398198, 34290314, 37340002, 37945903, 38632662	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	40050615	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Glioblastoma	Glioblastoma	Pubtator	33169458	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33169458, 36541697	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25491628	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for GMEB2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GMEB2.