GLS2 (glutaminase 2)

Gene Gene information from NCBI Gene database.
Gene SNPs Other IDs Associated diseases
Entrez ID 27165
Gene name Glutaminase 2
Gene symbol GLS2
Synonyms (NCBI Gene)
GAGLSLGAhLGA
Chromosome 12
Chromosome location 12q13.3
Summary The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in othe
miRNA miRNA information provided by mirtarbase database.
59
Gene SNPs Other IDs Associated diseases
Show/Hide all (59)
miRTarBase ID miRNA Experiments Reference
MIRT016977 hsa-miR-335-5p Microarray 18185580
MIRT734755 hsa-miR-1246 MicroarrayqRT-PCR 33610185
MIRT734756 hsa-miR-1260a MicroarrayqRT-PCR 33610185
MIRT734757 hsa-miR-146a-5p MicroarrayqRT-PCR 33610185
MIRT734758 hsa-miR-21-5p MicroarrayqRT-PCR 33610185
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
Gene SNPs Other IDs Associated diseases
Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0004359 Function Glutaminase activity IBA
GO:0004359 Function Glutaminase activity IEA
GO:0004359 Function Glutaminase activity TAS 10620514
GO:0005515 Function Protein binding IPI 11163757, 32296183, 33961781
GO:0005739 Component Mitochondrion HTP 34800366
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
606365 29570 ENSG00000135423
Protein Protein information from UniProt database.
Gene SNPs Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UI32
Protein name Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)
Protein function Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant functio
PDB 4BQM , 5U0K , 8SZL , 8T0Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17959 EF-hand_14 72 → 155 EF-hand domain Domain
PF04960 Glutaminase 177 → 463 Glutaminase Domain
PF12796 Ank_2 484 → 582 Ankyrin repeats (3 copies) Repeat
Tissue specificity TISSUE SPECIFICITY: Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269|PubMed:10620514, ECO:0000269|
Sequence
Sequence length 602
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene SNPs Other IDs Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GOUT — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (225)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 30266987
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 22042278, 28813436, 29343523, 29447943, 31209181, 9349841
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 7856567
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 23574722
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 31040157
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 11819789, 29796160
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 12408749
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 29343523
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Oligodendroglioma Oligodendroglioma BEFREE 17940881
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 37210557 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only