GLRX2 (glutaredoxin 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51022
• Gene name: Glutaredoxin 2
• Gene symbol: GLRX2
• Synonyms (NCBI Gene): CGI-133, GRX2
• Chromosome: 1
• Chromosome location: 1q31.2
• Summary: The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their

miRNA Show/Hide all (244)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030287	hsa-miR-26b-5p	Microarray	19088304
MIRT693276	hsa-miR-548aa	HITS-CLIP	21572407
MIRT693275	hsa-miR-548ap-3p	HITS-CLIP	21572407
MIRT693274	hsa-miR-548t-3p	HITS-CLIP	21572407
MIRT693273	hsa-miR-548as-3p	HITS-CLIP	21572407
MIRT693272	hsa-miR-548at-3p	HITS-CLIP	21572407
MIRT693271	hsa-miR-548ay-3p	HITS-CLIP	21572407
MIRT707310	hsa-miR-4282	HITS-CLIP	21572407
MIRT707309	hsa-miR-8063	HITS-CLIP	21572407
MIRT707308	hsa-miR-4698	HITS-CLIP	21572407
MIRT707307	hsa-miR-371b-5p	HITS-CLIP	21572407
MIRT707306	hsa-miR-373-5p	HITS-CLIP	21572407
MIRT707305	hsa-miR-616-5p	HITS-CLIP	21572407
MIRT516498	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT516499	hsa-miR-3662	HITS-CLIP	21572407
MIRT516497	hsa-miR-3163	HITS-CLIP	21572407
MIRT550841	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT516495	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT516494	hsa-miR-203a-3p	HITS-CLIP	21572407
MIRT516493	hsa-miR-567	HITS-CLIP	21572407
MIRT516492	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT516491	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT516490	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516489	hsa-miR-297	HITS-CLIP	21572407
MIRT693276	hsa-miR-548aa	HITS-CLIP	23313552
MIRT693275	hsa-miR-548ap-3p	HITS-CLIP	23313552
MIRT693274	hsa-miR-548t-3p	HITS-CLIP	23313552
MIRT693273	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT693272	hsa-miR-548at-3p	HITS-CLIP	23313552
MIRT693271	hsa-miR-548ay-3p	HITS-CLIP	23313552
MIRT516497	hsa-miR-3163	HITS-CLIP	23313552
MIRT550841	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516496	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693270	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT516490	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT693269	hsa-miR-6083	HITS-CLIP	23313552
MIRT516498	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT674841	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT674840	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT674839	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT674838	hsa-miR-564	HITS-CLIP	23824327
MIRT674837	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT637256	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT637255	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT637254	hsa-miR-5690	HITS-CLIP	23824327
MIRT637253	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT637252	hsa-miR-4459	HITS-CLIP	23824327
MIRT637251	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT637245	hsa-miR-665	HITS-CLIP	23824327
MIRT657769	hsa-miR-6078	HITS-CLIP	23824327
MIRT637250	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT637249	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT637248	hsa-miR-4518	HITS-CLIP	23824327
MIRT637247	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT657770	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT637257	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT637256	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT637255	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT637254	hsa-miR-5690	HITS-CLIP	23824327
MIRT637252	hsa-miR-4459	HITS-CLIP	23824327
MIRT637251	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT657769	hsa-miR-6078	HITS-CLIP	23824327
MIRT637250	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT637249	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT637248	hsa-miR-4518	HITS-CLIP	23824327
MIRT637247	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT637245	hsa-miR-665	HITS-CLIP	23824327
MIRT637257	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT637256	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT637255	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT637254	hsa-miR-5690	HITS-CLIP	23824327
MIRT637253	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT637252	hsa-miR-4459	HITS-CLIP	23824327
MIRT637251	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT637250	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT637249	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT637248	hsa-miR-4518	HITS-CLIP	23824327
MIRT637247	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT637245	hsa-miR-665	HITS-CLIP	23824327
MIRT516499	hsa-miR-3662	PAR-CLIP	21572407
MIRT516497	hsa-miR-3163	PAR-CLIP	21572407
MIRT550841	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516496	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516495	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT516494	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT516493	hsa-miR-567	PAR-CLIP	21572407
MIRT516492	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT516491	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT516490	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516489	hsa-miR-297	PAR-CLIP	21572407
MIRT516498	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516499	hsa-miR-3662	PAR-CLIP	21572407
MIRT516498	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516496	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516495	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT516493	hsa-miR-567	PAR-CLIP	21572407
MIRT516492	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT516491	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT516490	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516489	hsa-miR-297	PAR-CLIP	21572407
MIRT516499	hsa-miR-3662	PAR-CLIP	23446348
MIRT516498	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT516497	hsa-miR-3163	PAR-CLIP	23446348
MIRT516496	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516495	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT516494	hsa-miR-203a-3p	PAR-CLIP	23446348
MIRT516493	hsa-miR-567	PAR-CLIP	23446348
MIRT516492	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT516491	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT516490	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516489	hsa-miR-297	PAR-CLIP	23446348
MIRT693276	hsa-miR-548aa	HITS-CLIP	21572407
MIRT693275	hsa-miR-548ap-3p	HITS-CLIP	21572407
MIRT693274	hsa-miR-548t-3p	HITS-CLIP	21572407
MIRT693273	hsa-miR-548as-3p	HITS-CLIP	21572407
MIRT693272	hsa-miR-548at-3p	HITS-CLIP	21572407
MIRT693271	hsa-miR-548ay-3p	HITS-CLIP	21572407
MIRT707310	hsa-miR-4282	HITS-CLIP	21572407
MIRT707309	hsa-miR-8063	HITS-CLIP	21572407
MIRT707308	hsa-miR-4698	HITS-CLIP	21572407
MIRT707307	hsa-miR-371b-5p	HITS-CLIP	21572407
MIRT707306	hsa-miR-373-5p	HITS-CLIP	21572407
MIRT707305	hsa-miR-616-5p	HITS-CLIP	21572407
MIRT516498	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT516499	hsa-miR-3662	HITS-CLIP	21572407
MIRT516497	hsa-miR-3163	HITS-CLIP	21572407
MIRT550841	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT516495	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT516494	hsa-miR-203a-3p	HITS-CLIP	21572407
MIRT516493	hsa-miR-567	HITS-CLIP	21572407
MIRT516492	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT516491	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT516490	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516489	hsa-miR-297	HITS-CLIP	21572407
MIRT693276	hsa-miR-548aa	HITS-CLIP	23313552
MIRT693275	hsa-miR-548ap-3p	HITS-CLIP	23313552
MIRT693274	hsa-miR-548t-3p	HITS-CLIP	23313552
MIRT693273	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT693272	hsa-miR-548at-3p	HITS-CLIP	23313552
MIRT693271	hsa-miR-548ay-3p	HITS-CLIP	23313552
MIRT516497	hsa-miR-3163	HITS-CLIP	23313552
MIRT550841	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516496	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693270	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT516490	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT693269	hsa-miR-6083	HITS-CLIP	23313552
MIRT516498	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT674841	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT674840	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT674839	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT674838	hsa-miR-564	HITS-CLIP	23824327
MIRT674837	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT637256	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT637255	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT637254	hsa-miR-5690	HITS-CLIP	23824327
MIRT637253	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT637252	hsa-miR-4459	HITS-CLIP	23824327
MIRT637251	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT637245	hsa-miR-665	HITS-CLIP	23824327
MIRT657769	hsa-miR-6078	HITS-CLIP	23824327
MIRT637250	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT637249	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT637248	hsa-miR-4518	HITS-CLIP	23824327
MIRT637247	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT657770	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT637257	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT637256	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT637255	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT637254	hsa-miR-5690	HITS-CLIP	23824327
MIRT637252	hsa-miR-4459	HITS-CLIP	23824327
MIRT637251	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT657769	hsa-miR-6078	HITS-CLIP	23824327
MIRT637250	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT637249	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT637248	hsa-miR-4518	HITS-CLIP	23824327
MIRT637247	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT637245	hsa-miR-665	HITS-CLIP	23824327
MIRT637257	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT637256	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT637255	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT637254	hsa-miR-5690	HITS-CLIP	23824327
MIRT637253	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT637252	hsa-miR-4459	HITS-CLIP	23824327
MIRT637251	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT637250	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT637249	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT637248	hsa-miR-4518	HITS-CLIP	23824327
MIRT637247	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT637246	hsa-miR-7977	HITS-CLIP	23824327
MIRT637245	hsa-miR-665	HITS-CLIP	23824327
MIRT516499	hsa-miR-3662	PAR-CLIP	21572407
MIRT516497	hsa-miR-3163	PAR-CLIP	21572407
MIRT550841	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516496	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516495	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT516494	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT516493	hsa-miR-567	PAR-CLIP	21572407
MIRT516492	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT516491	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT516490	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516489	hsa-miR-297	PAR-CLIP	21572407
MIRT516498	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516499	hsa-miR-3662	PAR-CLIP	21572407
MIRT516498	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516496	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516495	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT516493	hsa-miR-567	PAR-CLIP	21572407
MIRT516492	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT516491	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT516490	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516489	hsa-miR-297	PAR-CLIP	21572407
MIRT516499	hsa-miR-3662	PAR-CLIP	23446348
MIRT516498	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT516497	hsa-miR-3163	PAR-CLIP	23446348
MIRT516496	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516495	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT516494	hsa-miR-203a-3p	PAR-CLIP	23446348
MIRT516493	hsa-miR-567	PAR-CLIP	23446348
MIRT516492	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT516491	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT516490	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516489	hsa-miR-297	PAR-CLIP	23446348
MIRT1021433	hsa-miR-3117-5p	CLIP-seq
MIRT1021434	hsa-miR-4661-5p	CLIP-seq
MIRT1021435	hsa-miR-548p	CLIP-seq
MIRT2002664	hsa-miR-1206	CLIP-seq
MIRT1021433	hsa-miR-3117-5p	CLIP-seq
MIRT2002665	hsa-miR-3692	CLIP-seq
MIRT2002666	hsa-miR-4528	CLIP-seq
MIRT1021434	hsa-miR-4661-5p	CLIP-seq
MIRT1021435	hsa-miR-548p	CLIP-seq
MIRT1021433	hsa-miR-3117-5p	CLIP-seq
MIRT1021434	hsa-miR-4661-5p	CLIP-seq
MIRT1021435	hsa-miR-548p	CLIP-seq
MIRT1021433	hsa-miR-3117-5p	CLIP-seq
MIRT1021434	hsa-miR-4661-5p	CLIP-seq
MIRT1021435	hsa-miR-548p	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003756	Function	Protein disulfide isomerase activity	TAS	11297543, 11397793
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	11297543
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	11297543, 11397793
GO:0005739	Component	Mitochondrion	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	11297543
GO:0006749	Process	Glutathione metabolic process	TAS	11397793
GO:0006915	Process	Apoptotic process	NAS	11297543
GO:0008794	Function	Arsenate reductase (glutaredoxin) activity	TAS	11297543, 11397793
GO:0009055	Function	Electron transfer activity	NAS	11297543
GO:0009266	Process	Response to temperature stimulus	NAS	11397793
GO:0009966	Process	Regulation of signal transduction	NAS	11297543
GO:0015035	Function	Protein-disulfide reductase activity	IBA
GO:0015038	Function	Glutathione disulfide oxidoreductase activity	TAS	11297543, 11397793
GO:0030154	Process	Cell differentiation	NAS	11297543
GO:0042262	Process	DNA protection	NAS	11297543, 11397793
GO:0045454	Process	Cell redox homeostasis	TAS	11397793
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IEA
GO:0051775	Process	Response to redox state	TAS	11297543

Other IDs

• MIM: 606820
• HGNC: 16065
• e!Ensembl: ENSG00000023572

Protein

• UniProt ID: Q9NS18
• Protein name: Glutaredoxin-2, mitochondrial
• Protein function: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative s
• PDB: 2CQ9 , 2FLS , 2HT9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00462	Glutaredoxin	69 → 131	Glutaredoxin	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:1518
• Sequence:

  MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQI
  QETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERT
  VPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ

• Sequence length: 164

Related Genes

No strongly related genes found yet for GLRX2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GLRX2.