GLB1L (galactosidase beta 1 like)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79411
• Gene name: Galactosidase beta 1 like
• Gene symbol: GLB1L
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q35

miRNA Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1020401	hsa-miR-3149	CLIP-seq
MIRT1020402	hsa-miR-3591-5p	CLIP-seq
MIRT1020403	hsa-miR-3681	CLIP-seq
MIRT1020404	hsa-miR-4460	CLIP-seq
MIRT1020405	hsa-miR-4727-3p	CLIP-seq
MIRT1020406	hsa-miR-483-5p	CLIP-seq
MIRT1020407	hsa-miR-5096	CLIP-seq
MIRT1020408	hsa-miR-877	CLIP-seq
MIRT2002179	hsa-miR-122	CLIP-seq
MIRT2002180	hsa-miR-197	CLIP-seq
MIRT2002181	hsa-miR-3135b	CLIP-seq
MIRT1020401	hsa-miR-3149	CLIP-seq
MIRT2002182	hsa-miR-3157-5p	CLIP-seq
MIRT2002183	hsa-miR-3187-3p	CLIP-seq
MIRT1020402	hsa-miR-3591-5p	CLIP-seq
MIRT2002184	hsa-miR-3652	CLIP-seq
MIRT2002185	hsa-miR-3680	CLIP-seq
MIRT1020403	hsa-miR-3681	CLIP-seq
MIRT2002186	hsa-miR-4430	CLIP-seq
MIRT2002187	hsa-miR-4435	CLIP-seq
MIRT1020404	hsa-miR-4460	CLIP-seq
MIRT2002188	hsa-miR-4691-3p	CLIP-seq
MIRT2002189	hsa-miR-4701-5p	CLIP-seq
MIRT2002190	hsa-miR-4716-5p	CLIP-seq
MIRT1020405	hsa-miR-4727-3p	CLIP-seq
MIRT2002191	hsa-miR-4735-5p	CLIP-seq
MIRT2002192	hsa-miR-4755-3p	CLIP-seq
MIRT2002193	hsa-miR-4775	CLIP-seq
MIRT2002194	hsa-miR-4781-3p	CLIP-seq
MIRT1020406	hsa-miR-483-5p	CLIP-seq
MIRT1020407	hsa-miR-5096	CLIP-seq
MIRT2002195	hsa-miR-548s	CLIP-seq
MIRT2002196	hsa-miR-588	CLIP-seq
MIRT2002197	hsa-miR-590-3p	CLIP-seq
MIRT2235181	hsa-miR-106a	CLIP-seq
MIRT2235182	hsa-miR-106b	CLIP-seq
MIRT2002179	hsa-miR-122	CLIP-seq
MIRT2235183	hsa-miR-150	CLIP-seq
MIRT2235184	hsa-miR-17	CLIP-seq
MIRT2002180	hsa-miR-197	CLIP-seq
MIRT2235185	hsa-miR-20a	CLIP-seq
MIRT2235186	hsa-miR-20b	CLIP-seq
MIRT2235187	hsa-miR-302a	CLIP-seq
MIRT2235188	hsa-miR-302b	CLIP-seq
MIRT2235189	hsa-miR-302c	CLIP-seq
MIRT2235190	hsa-miR-302d	CLIP-seq
MIRT2235191	hsa-miR-302e	CLIP-seq
MIRT2002181	hsa-miR-3135b	CLIP-seq
MIRT2002182	hsa-miR-3157-5p	CLIP-seq
MIRT2002183	hsa-miR-3187-3p	CLIP-seq
MIRT1020402	hsa-miR-3591-5p	CLIP-seq
MIRT2235192	hsa-miR-3616-5p	CLIP-seq
MIRT2235193	hsa-miR-3647-5p	CLIP-seq
MIRT2002184	hsa-miR-3652	CLIP-seq
MIRT2235194	hsa-miR-3663-5p	CLIP-seq
MIRT1020403	hsa-miR-3681	CLIP-seq
MIRT2235195	hsa-miR-3690	CLIP-seq
MIRT2235196	hsa-miR-372	CLIP-seq
MIRT2235197	hsa-miR-373	CLIP-seq
MIRT2235198	hsa-miR-4254	CLIP-seq
MIRT2235199	hsa-miR-4320	CLIP-seq
MIRT2002186	hsa-miR-4430	CLIP-seq
MIRT2002187	hsa-miR-4435	CLIP-seq
MIRT1020404	hsa-miR-4460	CLIP-seq
MIRT2235200	hsa-miR-4635	CLIP-seq
MIRT2002188	hsa-miR-4691-3p	CLIP-seq
MIRT2002189	hsa-miR-4701-5p	CLIP-seq
MIRT2002190	hsa-miR-4716-5p	CLIP-seq
MIRT1020405	hsa-miR-4727-3p	CLIP-seq
MIRT2002192	hsa-miR-4755-3p	CLIP-seq
MIRT2002194	hsa-miR-4781-3p	CLIP-seq
MIRT1020406	hsa-miR-483-5p	CLIP-seq
MIRT2235201	hsa-miR-498	CLIP-seq
MIRT1020407	hsa-miR-5096	CLIP-seq
MIRT2235202	hsa-miR-512-3p	CLIP-seq
MIRT2235203	hsa-miR-519d	CLIP-seq
MIRT2235204	hsa-miR-520a-3p	CLIP-seq
MIRT2235205	hsa-miR-520b	CLIP-seq
MIRT2235206	hsa-miR-520c-3p	CLIP-seq
MIRT2235207	hsa-miR-520d-3p	CLIP-seq
MIRT2235208	hsa-miR-520e	CLIP-seq
MIRT2235209	hsa-miR-520g	CLIP-seq
MIRT2235210	hsa-miR-520h	CLIP-seq
MIRT2002195	hsa-miR-548s	CLIP-seq
MIRT2235211	hsa-miR-573	CLIP-seq
MIRT2002196	hsa-miR-588	CLIP-seq
MIRT2235212	hsa-miR-93	CLIP-seq
MIRT1020401	hsa-miR-3149	CLIP-seq
MIRT1020402	hsa-miR-3591-5p	CLIP-seq
MIRT1020403	hsa-miR-3681	CLIP-seq
MIRT2235195	hsa-miR-3690	CLIP-seq
MIRT2235198	hsa-miR-4254	CLIP-seq
MIRT2235199	hsa-miR-4320	CLIP-seq
MIRT1020404	hsa-miR-4460	CLIP-seq
MIRT1020405	hsa-miR-4727-3p	CLIP-seq
MIRT2002191	hsa-miR-4735-5p	CLIP-seq
MIRT2002193	hsa-miR-4775	CLIP-seq
MIRT1020406	hsa-miR-483-5p	CLIP-seq
MIRT2235201	hsa-miR-498	CLIP-seq
MIRT2002197	hsa-miR-590-3p	CLIP-seq
MIRT2235183	hsa-miR-150	CLIP-seq
MIRT2002180	hsa-miR-197	CLIP-seq
MIRT2538963	hsa-miR-1976	CLIP-seq
MIRT1020401	hsa-miR-3149	CLIP-seq
MIRT1020402	hsa-miR-3591-5p	CLIP-seq
MIRT1020403	hsa-miR-3681	CLIP-seq
MIRT2235195	hsa-miR-3690	CLIP-seq
MIRT2235198	hsa-miR-4254	CLIP-seq
MIRT2538964	hsa-miR-4279	CLIP-seq
MIRT2235199	hsa-miR-4320	CLIP-seq
MIRT1020404	hsa-miR-4460	CLIP-seq
MIRT2002190	hsa-miR-4716-5p	CLIP-seq
MIRT2538965	hsa-miR-4722-3p	CLIP-seq
MIRT1020405	hsa-miR-4727-3p	CLIP-seq
MIRT2002191	hsa-miR-4735-5p	CLIP-seq
MIRT2002192	hsa-miR-4755-3p	CLIP-seq
MIRT2002193	hsa-miR-4775	CLIP-seq
MIRT2002194	hsa-miR-4781-3p	CLIP-seq
MIRT1020406	hsa-miR-483-5p	CLIP-seq
MIRT2235201	hsa-miR-498	CLIP-seq
MIRT1020407	hsa-miR-5096	CLIP-seq
MIRT2002197	hsa-miR-590-3p	CLIP-seq
MIRT1020408	hsa-miR-877	CLIP-seq
MIRT2002180	hsa-miR-197	CLIP-seq
MIRT2538963	hsa-miR-1976	CLIP-seq
MIRT1020401	hsa-miR-3149	CLIP-seq
MIRT1020402	hsa-miR-3591-5p	CLIP-seq
MIRT1020403	hsa-miR-3681	CLIP-seq
MIRT2235195	hsa-miR-3690	CLIP-seq
MIRT2235198	hsa-miR-4254	CLIP-seq
MIRT2538964	hsa-miR-4279	CLIP-seq
MIRT2235199	hsa-miR-4320	CLIP-seq
MIRT1020404	hsa-miR-4460	CLIP-seq
MIRT1020405	hsa-miR-4727-3p	CLIP-seq
MIRT2002191	hsa-miR-4735-5p	CLIP-seq
MIRT2002193	hsa-miR-4775	CLIP-seq
MIRT1020406	hsa-miR-483-5p	CLIP-seq
MIRT2235201	hsa-miR-498	CLIP-seq
MIRT1020407	hsa-miR-5096	CLIP-seq
MIRT2002197	hsa-miR-590-3p	CLIP-seq
MIRT1020408	hsa-miR-877	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0004565	Function	Beta-galactosidase activity	IBA
GO:0004565	Function	Beta-galactosidase activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005773	Component	Vacuole	IBA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0019388	Process	Galactose catabolic process	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6UWU2
• Protein name: Beta-galactosidase-1-like protein (EC 3.2.1.-)
• Protein function: Probable glycosyl hydrolase.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01301	Glyco_hydro_35	38 → 355	Glycosyl hydrolases family 35	Domain

• Sequence:

  MAPKKLSCLRSLLLPLSLTLLLPQADTRSFVVDRGHDRFLLDGAPFRYVSGSLHYFRVPR
  VLWADRLLKMRWSGLNAIQFYVPWNYHEPQPGVYNFNGSRDLIAFLNEAALANLLVILRP
  GPYICAEWEMGGLPSWLLRKPEIHLRTSDPDFLAAVDSWFKVLLPKIYPWLYHNGGNIIS
  IQVENEYGSYRACDFSYMRHLAGLFRALLGEKILLFTTDGPEGLKCGSLRGLYTTVDFGP
  ADNMTKIFTLLRKYEPHGPLVNSEYYTGWLDYWGQNHSTRSVSAVTKGLENMLKLGASVN
  MYMFHGGTNFGYWNGADKKGRFLPITTSYDYDAPISEAGDPTPKLFALRDVISKFQEVPL
  GPLPPPSPKMMLGPVTLHLVGHLLAFLDLLCPRGPIHSILPMTFEAVKQDHGFMLYRTYM
  THTIFEPTPFWVPNNGVHDRAYVMVDGVFQGVVERNMRDKLFLTGKLGSKLDILVENMGR
  LSFGSNSSDFKGLLKPPILGQTILTQWMMFPLKIDNLVKWWFPLQLPKWPYPQAPSGPTF
  YSKTFPILGSVGDTFLYLPGWTKGQVWINGFNLGRYWTKQGPQQTLYVPRFLLFPRGALN
  KITLLELEDVPLQPQVQFLDKPILNSTSTLHRTHINSLSADTLSASEPMELSGH

• Sequence length: 654

Pathways

Reactome Pathway

Glycosphingolipid metabolism

Keratan sulfate degradation

HS-GAG degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (6)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29182684	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

GLB1 3 shared pathwaysHS-GAG degradation, Glycosphingolipid metabolism, Keratan sulfate degradation Related via 3 shared pathways including HS-GAG degradation, Glycosphingolipid metabolism. HEXA 2 shared pathwaysGlycosphingolipid metabolism, Keratan sulfate degradation Related via 2 shared pathways including Glycosphingolipid metabolism, Keratan sulfate degradation. HEXB 2 shared pathwaysGlycosphingolipid metabolism, Keratan sulfate degradation Related via 2 shared pathways including Glycosphingolipid metabolism, Keratan sulfate degradation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
GLB1	0	[]	3	["HS-GAG degradation","Glycosphingolipid metabolism","Keratan sulfate degradation"]	0	[]
HEXA	0	[]	2	["Glycosphingolipid metabolism","Keratan sulfate degradation"]	0	[]
HEXB	0	[]	2	["Glycosphingolipid metabolism","Keratan sulfate degradation"]	0	[]

Diseases Linked via Similar Genes

Asthma Linked via 1 of 3 related genesGLB1 Eczema Linked via 1 of 3 related genesGLB1 Bone disease Linked via 1 of 3 related genesGLB1 Celiac disease Linked via 1 of 3 related genesGLB1 Obstructive pulmonary disease Linked via 1 of 3 related genesGLB1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Asthma	1	["GLB1"]
Eczema	1	["GLB1"]
Bone disease	1	["GLB1"]
Celiac disease	1	["GLB1"]
Obstructive pulmonary disease	1	["GLB1"]