GJA9 (gap junction protein alpha 9)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 81025
• Gene name: Gap junction protein alpha 9
• Gene symbol: GJA9
• Synonyms (NCBI Gene): CX58, CX59, GJA10
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin s

miRNA Show/Hide all (18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1019734	hsa-miR-3646	CLIP-seq
MIRT1019735	hsa-miR-4452	CLIP-seq
MIRT1019736	hsa-miR-4720-3p	CLIP-seq
MIRT1019737	hsa-miR-4753-3p	CLIP-seq
MIRT1019738	hsa-miR-4768-5p	CLIP-seq
MIRT1019739	hsa-miR-4804-3p	CLIP-seq
MIRT1019740	hsa-miR-511	CLIP-seq
MIRT1019741	hsa-miR-654-3p	CLIP-seq
MIRT2001973	hsa-miR-3607-5p	CLIP-seq
MIRT2538861	hsa-miR-3977	CLIP-seq
MIRT2538862	hsa-miR-513b	CLIP-seq
MIRT1019734	hsa-miR-3646	CLIP-seq
MIRT2538861	hsa-miR-3977	CLIP-seq
MIRT1019736	hsa-miR-4720-3p	CLIP-seq
MIRT1019737	hsa-miR-4753-3p	CLIP-seq
MIRT1019738	hsa-miR-4768-5p	CLIP-seq
MIRT1019739	hsa-miR-4804-3p	CLIP-seq
MIRT2538862	hsa-miR-513b	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005243	Function	Gap junction channel activity	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005921	Component	Gap junction	IEA
GO:0005922	Component	Connexin complex	IBA
GO:0005922	Component	Connexin complex	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007267	Process	Cell-cell signaling	IBA
GO:0016020	Component	Membrane	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 611923
• HGNC: 19155
• e!Ensembl: ENSG00000131233

Protein

• UniProt ID: P57773
• Protein name: Gap junction alpha-9 protein (Connexin-58) (Cx58) (Connexin-59) (Cx59) (Gap junction alpha-10 protein)
• Protein function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00029	Connexin	3 → 235	Connexin	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly abundant in skeletal muscle. Also detected in testis. {ECO:0000269|PubMed:12881038}.
• Sequence:

  MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPG
  CRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRVELEE
  VEFEMPRDRRRLEQELCQLEKRKLNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLYG
  FHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIKR
  GLWGKYKLKKEHNEFHANKAKQNVAKYQSTSANSLKRLPSAPDYNLLVEKQTHTAVYPSL
  NSSSVFQPNPDNHSVNDEKCILDEQETVLSNEISTLSTSCSHFQHISSNNNKDTHKIFGK
  ELNGNQLMEKRETEGKDSKRNYYSRGHRSIPGVAIDGENNMRQSPQTVFSLPANCDWKPR
  WLRATWGSSTEHENRGSPPKGNLKGQFRKGTVRTLPPSQGDSQSLDIPNTADSLGGLSFE
  PGLVRTCNNPVCPPNHVVSLTNNLIGRRVPTDLQI

• Sequence length: 515

Pathways

Reactome Pathway:

Gap junction assembly

Related Genes

No strongly related genes found yet for GJA9.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GJA9.