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Gene Gene information from NCBI Gene database.
Entrez ID 84296
Gene name GINS complex subunit 4
Gene symbol GINS4
Synonyms (NCBI Gene)
SLD5
Chromosome 8
Chromosome location 8p11.21
Summary The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg ext
miRNA miRNA information provided by mirtarbase database.
593 Show/Hide all (593)
miRTarBase ID miRNA Experiments Reference
MIRT029376 hsa-miR-26b-5p Microarray 19088304
MIRT657873 hsa-miR-203a-3p HITS-CLIP 23824327
MIRT657872 hsa-miR-4272 HITS-CLIP 23824327
MIRT657871 hsa-miR-510-3p HITS-CLIP 23824327
MIRT503446 hsa-miR-3609 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000727 Process Double-strand break repair via break-induced replication IBA
GO:0000811 Component GINS complex IBA
GO:0000811 Component GINS complex IPI 17417653
GO:0001833 Process Inner cell mass cell proliferation IEA
GO:0005515 Function Protein binding IPI 16189514, 17417653, 17652513, 19805216, 22540012, 24299456, 25416956, 28514442, 31515488, 32296183, 32707033, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610611 28226 ENSG00000147536
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BRT9
Protein name DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]
Protein function Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of C
PDB 2E9X , 2EHO , 2Q9Q , 6XTX , 6XTY , 7PFO , 7PLO , 8B9D , 8OK2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05916 Sld5 21 → 127 GINS complex protein Family
PF16922 SLD5_C 165 → 223 DNA replication complex GINS protein SLD5 C-terminus Domain
Sequence
Sequence length 223
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Unwinding of DNA