GID8 (GID complex subunit 8 homolog)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54994
• Gene name: GID complex subunit 8 homolog
• Gene symbol: GID8
• Synonyms (NCBI Gene): C20orf11, TWA1
• Chromosome: 20
• Chromosome location: 20q13.33

miRNA Show/Hide all (21)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016102	hsa-miR-421	Sequencing	20371350
MIRT019562	hsa-miR-340-5p	Sequencing	20371350
MIRT024155	hsa-miR-221-3p	Sequencing	20371350
MIRT026715	hsa-miR-192-5p	Microarray	19074876
MIRT048257	hsa-miR-196a-5p	CLASH	23622248
MIRT043190	hsa-miR-324-5p	CLASH	23622248
MIRT437737	hsa-miR-342-3p	Microarray, qRT-PCR	22815788
MIRT537159	hsa-miR-646	PAR-CLIP	22012620
MIRT537158	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT537156	hsa-miR-6736-3p	PAR-CLIP	22012620
MIRT537157	hsa-miR-132-5p	PAR-CLIP	22012620
MIRT537155	hsa-miR-3188	PAR-CLIP	22012620
MIRT537154	hsa-miR-4660	PAR-CLIP	22012620
MIRT537153	hsa-miR-6081	PAR-CLIP	22012620
MIRT537159	hsa-miR-646	PAR-CLIP	22012620
MIRT537158	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT537156	hsa-miR-6736-3p	PAR-CLIP	22012620
MIRT537157	hsa-miR-132-5p	PAR-CLIP	22012620
MIRT537155	hsa-miR-3188	PAR-CLIP	22012620
MIRT537154	hsa-miR-4660	PAR-CLIP	22012620
MIRT537153	hsa-miR-6081	PAR-CLIP	22012620

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IDA	29911972
GO:0005515	Function	Protein binding	IPI	27173435, 28514442, 28829046, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17467196, 24143168, 28829046, 29911972
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	17467196
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	24143168
GO:0005829	Component	Cytosol	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	28829046
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030054	Component	Cell junction	IDA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	28829046

Other IDs

• MIM: 611625
• HGNC: 15857
• e!Ensembl: ENSG00000101193

Protein

• UniProt ID: Q9NWU2
• Protein name: Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)
• Protein function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positiv
• PDB: 7NSC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08513	LisH	27 → 53	LisH	Domain
  PF10607	CLTH	63 → 207	CTLH/CRA C-terminal to LisH motif domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Up-regulated in colorectal cancer tissues (at protein level). {ECO:0000269|PubMed:28829046}.
• Sequence:

  MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVD
  LETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEA
  ALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHTMQRQKVWSEVNQAV
  LDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK

• Sequence length: 228

Related Genes

No strongly related genes found yet for GID8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GID8.