Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	79833
Gene name	Gem nuclear organelle associated protein 6
Gene symbol	GEMIN6
Synonyms (NCBI Gene)	-
Chromosome	2
Chromosome location	2p22.1
Summary	GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (

125 Show/Hide all (125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049420	hsa-miR-92a-3p	CLASH	23622248
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT623819	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT623818	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT453682	hsa-miR-4257	PAR-CLIP	23592263
MIRT453681	hsa-miR-1827	PAR-CLIP	23592263
MIRT453680	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT453679	hsa-miR-6086	PAR-CLIP	23592263
MIRT453678	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT453677	hsa-miR-3612	PAR-CLIP	23592263
MIRT453676	hsa-miR-650	PAR-CLIP	23592263
MIRT453675	hsa-miR-4536-5p	PAR-CLIP	23592263
MIRT449348	hsa-miR-548n	PAR-CLIP	22100165
MIRT449347	hsa-miR-548l	PAR-CLIP	22100165
MIRT449346	hsa-miR-630	PAR-CLIP	22100165
MIRT449345	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449343	hsa-miR-3161	PAR-CLIP	22100165
MIRT449344	hsa-miR-599	PAR-CLIP	22100165
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT623819	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT623818	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612984	hsa-miR-8485	HITS-CLIP	23824327
MIRT612983	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612982	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612981	hsa-miR-603	HITS-CLIP	23824327
MIRT612980	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612979	hsa-miR-3941	HITS-CLIP	23824327
MIRT612978	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT612977	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT453682	hsa-miR-4257	PAR-CLIP	23592263
MIRT453681	hsa-miR-1827	PAR-CLIP	23592263
MIRT453680	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT453679	hsa-miR-6086	PAR-CLIP	23592263
MIRT453678	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT453677	hsa-miR-3612	PAR-CLIP	23592263
MIRT453676	hsa-miR-650	PAR-CLIP	23592263
MIRT453675	hsa-miR-4536-5p	PAR-CLIP	23592263
MIRT449348	hsa-miR-548n	PAR-CLIP	22100165
MIRT449347	hsa-miR-548l	PAR-CLIP	22100165
MIRT449346	hsa-miR-630	PAR-CLIP	22100165
MIRT449345	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449343	hsa-miR-3161	PAR-CLIP	22100165
MIRT449344	hsa-miR-599	PAR-CLIP	22100165

25 Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000245	Process	Spliceosomal complex assembly	IEA
GO:0000387	Process	Spliceosomal snRNP assembly	EXP	12067652
GO:0000387	Process	Spliceosomal snRNP assembly	IBA
GO:0000387	Process	Spliceosomal snRNP assembly	IDA	18984161
GO:0000387	Process	Spliceosomal snRNP assembly	TAS	11748230
GO:0000398	Process	MRNA splicing, via spliceosome	TAS	11748230
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11748230, 12065586, 15848170, 15939020, 16189514, 17178713, 22190034, 25416956, 26496610, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	11748230
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	11748230
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18984161
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016604	Component	Nuclear body	IDA	11748230
GO:0032797	Component	SMN complex	IBA
GO:0032797	Component	SMN complex	IDA	17178713, 18984161
GO:0032797	Component	SMN complex	IPI	17178713
GO:0034719	Component	SMN-Sm protein complex	IDA	18984161
GO:0097504	Component	Gemini of Cajal bodies	IDA	20513430
GO:0097504	Component	Gemini of Cajal bodies	IEA

MIM	HGNC	e!Ensembl
607006	20044	ENSG00000152147

Q8WXD5

Protein name

Gem-associated protein 6 (Gemin-6) (SIP2)

Protein function

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set

PDB

1Y96 , 7BBL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06372	Gemin6	1 → 167	Gemin6 protein	Family

Sequence

MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGI
MGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEERKNSLKKWLEKNHIPITEQ
GDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIEGHLTASQ

Sequence length

167

Interactions

View interactions

Reactome Pathway
snRNP Assembly

Related Genes Genes most often co-reported with GEMIN6 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for GEMIN6.

Diseases Linked via Similar Genes Diseases curated for genes most similar to GEMIN6 (see Related Genes above), that are NOT already directly curated for GEMIN6 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to GEMIN6.

GEMIN6 (gem nuclear organelle associated protein 6)

Bookmark This Gene