GCM1 (glial cells missing transcription factor 1)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8521
• Gene name: Glial cells missing transcription factor 1
• Gene symbol: GCM1
• Synonyms (NCBI Gene): GCMA, hGCMa
• Chromosome: 6
• Chromosome location: 6p12.1
• Summary: This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets

miRNA Show/Hide all (84)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007272	hsa-miR-19b-3p	Luciferase reporter assay	23438603
MIRT1014839	hsa-miR-10a	CLIP-seq
MIRT1014840	hsa-miR-10b	CLIP-seq
MIRT1014841	hsa-miR-1193	CLIP-seq
MIRT1014842	hsa-miR-1254	CLIP-seq
MIRT1014843	hsa-miR-1285	CLIP-seq
MIRT1014844	hsa-miR-1294	CLIP-seq
MIRT1014845	hsa-miR-217	CLIP-seq
MIRT1014846	hsa-miR-2278	CLIP-seq
MIRT1014847	hsa-miR-3074-5p	CLIP-seq
MIRT1014848	hsa-miR-3116	CLIP-seq
MIRT1014849	hsa-miR-3122	CLIP-seq
MIRT1014850	hsa-miR-3187-5p	CLIP-seq
MIRT1014851	hsa-miR-34b	CLIP-seq
MIRT1014852	hsa-miR-3529	CLIP-seq
MIRT1014853	hsa-miR-3614-5p	CLIP-seq
MIRT1014854	hsa-miR-371-5p	CLIP-seq
MIRT1014855	hsa-miR-377	CLIP-seq
MIRT1014856	hsa-miR-379	CLIP-seq
MIRT1014857	hsa-miR-3913-5p	CLIP-seq
MIRT1014858	hsa-miR-3929	CLIP-seq
MIRT1014859	hsa-miR-4293	CLIP-seq
MIRT1014860	hsa-miR-4419b	CLIP-seq
MIRT1014861	hsa-miR-4433	CLIP-seq
MIRT1014862	hsa-miR-4451	CLIP-seq
MIRT1014863	hsa-miR-4459	CLIP-seq
MIRT1014864	hsa-miR-4470	CLIP-seq
MIRT1014865	hsa-miR-4478	CLIP-seq
MIRT1014866	hsa-miR-450b-3p	CLIP-seq
MIRT1014867	hsa-miR-4536	CLIP-seq
MIRT1014868	hsa-miR-4650-3p	CLIP-seq
MIRT1014869	hsa-miR-4710	CLIP-seq
MIRT1014870	hsa-miR-4722-3p	CLIP-seq
MIRT1014871	hsa-miR-4722-5p	CLIP-seq
MIRT1014872	hsa-miR-4768-3p	CLIP-seq
MIRT1014873	hsa-miR-4772-5p	CLIP-seq
MIRT1014874	hsa-miR-4792	CLIP-seq
MIRT1014875	hsa-miR-485-5p	CLIP-seq
MIRT1014876	hsa-miR-5096	CLIP-seq
MIRT1014877	hsa-miR-541	CLIP-seq
MIRT1014878	hsa-miR-612	CLIP-seq
MIRT1014879	hsa-miR-654-5p	CLIP-seq
MIRT1014880	hsa-miR-661	CLIP-seq
MIRT1014881	hsa-miR-769-3p	CLIP-seq
MIRT1014882	hsa-miR-888	CLIP-seq
MIRT1549180	hsa-miR-1252	CLIP-seq
MIRT1549181	hsa-miR-3148	CLIP-seq
MIRT1014851	hsa-miR-34b	CLIP-seq
MIRT1014854	hsa-miR-371-5p	CLIP-seq
MIRT1014871	hsa-miR-4722-5p	CLIP-seq
MIRT1014872	hsa-miR-4768-3p	CLIP-seq
MIRT1014882	hsa-miR-888	CLIP-seq
MIRT1014846	hsa-miR-2278	CLIP-seq
MIRT2234014	hsa-miR-24	CLIP-seq
MIRT2234015	hsa-miR-4284	CLIP-seq
MIRT1014859	hsa-miR-4293	CLIP-seq
MIRT1014861	hsa-miR-4433	CLIP-seq
MIRT1014863	hsa-miR-4459	CLIP-seq
MIRT2234016	hsa-miR-4755-3p	CLIP-seq
MIRT1014872	hsa-miR-4768-3p	CLIP-seq
MIRT2388397	hsa-miR-338-3p	CLIP-seq
MIRT2388398	hsa-miR-4474-3p	CLIP-seq
MIRT2388399	hsa-miR-570	CLIP-seq
MIRT1014839	hsa-miR-10a	CLIP-seq
MIRT1014840	hsa-miR-10b	CLIP-seq
MIRT2537897	hsa-miR-3121-3p	CLIP-seq
MIRT2537898	hsa-miR-339-5p	CLIP-seq
MIRT1014851	hsa-miR-34b	CLIP-seq
MIRT1014854	hsa-miR-371-5p	CLIP-seq
MIRT2537899	hsa-miR-4421	CLIP-seq
MIRT2537900	hsa-miR-4684-5p	CLIP-seq
MIRT1014871	hsa-miR-4722-5p	CLIP-seq
MIRT1014872	hsa-miR-4768-3p	CLIP-seq
MIRT2537901	hsa-miR-548c-3p	CLIP-seq
MIRT2537902	hsa-miR-593	CLIP-seq
MIRT1014882	hsa-miR-888	CLIP-seq
MIRT1014839	hsa-miR-10a	CLIP-seq
MIRT1014840	hsa-miR-10b	CLIP-seq
MIRT2537897	hsa-miR-3121-3p	CLIP-seq
MIRT2537898	hsa-miR-339-5p	CLIP-seq
MIRT2537899	hsa-miR-4421	CLIP-seq
MIRT2537900	hsa-miR-4684-5p	CLIP-seq
MIRT2537901	hsa-miR-548c-3p	CLIP-seq
MIRT2537902	hsa-miR-593	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC3	Unknown	16528103
KCNIP3	Repression	23300953
POU2F1	Unknown	11071865

Gene ontology (GO) Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000768	Process	Syncytium formation by plasma membrane fusion	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	15385555
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	23867755, 27917469
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	15385555
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	8962155
GO:0003700	Function	DNA-binding transcription factor activity	IDA	15385555
GO:0005515	Function	Protein binding	IPI	23651062, 23867755, 26899996, 28515447
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23867755
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8962155
GO:0005667	Component	Transcription regulator complex	IDA	15385555
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	15385555
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	23867755
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	8962155
GO:0042063	Process	Gliogenesis	IBA
GO:0042826	Function	Histone deacetylase binding	IPI	23867755
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	27917469
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	15385555
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060018	Process	Astrocyte fate commitment	IEA
GO:0060143	Process	Positive regulation of syncytium formation by plasma membrane fusion	IEA
GO:0060670	Process	Branching involved in labyrinthine layer morphogenesis	IEA
GO:0060706	Process	Cell differentiation involved in embryonic placenta development	IBA
GO:0060706	Process	Cell differentiation involved in embryonic placenta development	IEA
GO:0060800	Process	Regulation of cell differentiation involved in embryonic placenta development	IMP	19219068
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 603715
• HGNC: 4197
• e!Ensembl: ENSG00000137270

Protein

• UniProt ID: Q9NP62
• Protein name: Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1)
• Protein function: Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03615	GCM	30 → 167	GCM motif protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the placenta (PubMed:10542267). Expressed in trophoblast cells of the villi (PubMed:27917469). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:27917469}.
• Sequence:

  MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHIYSSEDKNAQRHLSSWA
  MRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICDKARQKQQRKRCPNCDGPL
  KLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVNTAPSSVS
  LSLKGSTETRSLPGETQSQGSLPLTWSFQEGVQLPGSYSGHLIANTPQQNSLNDCFSFSK
  SYGLGGITDLTDQTSTVDPMKLYEKRKLSSSRTYSSGDLLPPSASGVYSDHGDLQAWSKN
  AALGRNHLADNCYSNYPFPLTSWPCSFSPSQNSSEPFYQQLPLEPPAAKTGCPPLWPNPA
  GNLYEEKVHVDFNSYVQSPAYHSPQEDPFLFTYASHPHQQYSLPSKSSKWDFEEEMTYLG
  LDHCNNDMLLNLCPLR

• Sequence length: 436

Pathways

KEGG Pathway:

Parathyroid hormone synthesis, secretion and action

Related Genes

No strongly related genes found yet for GCM1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to GCM1.