Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	2595
Gene name	Glucosidase alpha, neutral C
Gene symbol	GANC
Synonyms (NCBI Gene)	-
Chromosome	15
Chromosome location	15q15.1
Summary	Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing

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miRTarBase ID	miRNA	Experiments
MIRT1011958	hsa-miR-1206	CLIP-seq
MIRT1011959	hsa-miR-129-5p	CLIP-seq
MIRT1011960	hsa-miR-2681	CLIP-seq
MIRT1011961	hsa-miR-300	CLIP-seq
MIRT1011962	hsa-miR-3126-5p	CLIP-seq
MIRT1011963	hsa-miR-3153	CLIP-seq
MIRT1011964	hsa-miR-3173-5p	CLIP-seq
MIRT1011965	hsa-miR-3184	CLIP-seq
MIRT1011966	hsa-miR-3189-3p	CLIP-seq
MIRT1011967	hsa-miR-325	CLIP-seq
MIRT1011968	hsa-miR-33a	CLIP-seq
MIRT1011969	hsa-miR-33b	CLIP-seq
MIRT1011970	hsa-miR-3675-5p	CLIP-seq
MIRT1011971	hsa-miR-370	CLIP-seq
MIRT1011972	hsa-miR-375	CLIP-seq
MIRT1011973	hsa-miR-381	CLIP-seq
MIRT1011974	hsa-miR-423-5p	CLIP-seq
MIRT1011975	hsa-miR-425	CLIP-seq
MIRT1011976	hsa-miR-4419a	CLIP-seq
MIRT1011977	hsa-miR-4462	CLIP-seq
MIRT1011978	hsa-miR-4506	CLIP-seq
MIRT1011979	hsa-miR-450b-5p	CLIP-seq
MIRT1011980	hsa-miR-4510	CLIP-seq
MIRT1011981	hsa-miR-4666-3p	CLIP-seq
MIRT1011982	hsa-miR-4688	CLIP-seq
MIRT1011983	hsa-miR-4710	CLIP-seq
MIRT1011984	hsa-miR-486-3p	CLIP-seq
MIRT1011985	hsa-miR-488	CLIP-seq
MIRT1011986	hsa-miR-507	CLIP-seq
MIRT1011987	hsa-miR-526b	CLIP-seq
MIRT1011988	hsa-miR-557	CLIP-seq
MIRT1011989	hsa-miR-624	CLIP-seq
MIRT1011990	hsa-miR-628-3p	CLIP-seq
MIRT1011991	hsa-miR-635	CLIP-seq
MIRT1011992	hsa-miR-767-5p	CLIP-seq
MIRT1999801	hsa-miR-103a	CLIP-seq
MIRT1999802	hsa-miR-107	CLIP-seq
MIRT1011958	hsa-miR-1206	CLIP-seq
MIRT1011959	hsa-miR-129-5p	CLIP-seq
MIRT1999803	hsa-miR-1301	CLIP-seq
MIRT1011972	hsa-miR-375	CLIP-seq
MIRT1999804	hsa-miR-4270	CLIP-seq
MIRT1999805	hsa-miR-4441	CLIP-seq
MIRT1999806	hsa-miR-4470	CLIP-seq
MIRT1999807	hsa-miR-5047	CLIP-seq
MIRT1999808	hsa-miR-545	CLIP-seq
MIRT1999809	hsa-miR-548c-3p	CLIP-seq
MIRT1999810	hsa-miR-548p	CLIP-seq
MIRT2233232	hsa-miR-2113	CLIP-seq
MIRT2233233	hsa-miR-214	CLIP-seq
MIRT2233234	hsa-miR-3619-5p	CLIP-seq
MIRT2233235	hsa-miR-3922-5p	CLIP-seq
MIRT2233236	hsa-miR-4252	CLIP-seq
MIRT1999804	hsa-miR-4270	CLIP-seq
MIRT1999805	hsa-miR-4441	CLIP-seq
MIRT2233237	hsa-miR-4753-5p	CLIP-seq
MIRT2233238	hsa-miR-761	CLIP-seq
MIRT1011966	hsa-miR-3189-3p	CLIP-seq
MIRT1011991	hsa-miR-635	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0004558	Function	Alpha-1,4-glucosidase activity	IBA
GO:0004558	Function	Alpha-1,4-glucosidase activity	IEA
GO:0004558	Function	Alpha-1,4-glucosidase activity	NAS	12370436
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006491	Process	N-glycan processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0090599	Function	Alpha-glucosidase activity	IEA

MIM	HGNC	e!Ensembl
104180	4139	ENSG00000214013

Q8TET4

Protein name

Neutral alpha-glucosidase C (EC 3.2.1.20)

Protein function

Has alpha-glucosidase activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01055	Glyco_hydro_31	334 → 779	Glycosyl hydrolases family 31	Family
PF13802	Gal_mutarotas_2	222 → 293	Galactose mutarotase-like	Domain

Sequence

MEAAVKEEISLEDEAVDKNIFRDCNKIAFYRRQKQWLSKKSTYQALLDSVTTDEDSTRFQ
IINEASKVPLLAEIYGIEGNIFRLKINEETPLKPRFEVPDVLTSKPSTVRLISCSGDTGS
LILADGKGDLKCHITANPFKVDLVSEEEVVISINSLGQLYFEHLQILHKQRAAKENEEET
SVDTSQENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNT
GDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINTEPAV
EYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPL
FSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKR
MQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKDQGFFVKNQEGEDFEGVCWPGLSSYLD
FTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHREL
HNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIP
MLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHATMNTKRREPWLFGE
EHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGSA
LLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIP
IKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQKQFLHRKFSFCSSV
LINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLEK
LSLNIATDWEVRII

Sequence length

914

Interactions

View interactions

KEGG Pathway
Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Lung cancer	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Congenital dyserythropoietic anemia	Congenital dyserythropoietic anemia	LHGDN	12434312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	12370436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	29391400		★★★★★ ★☆☆☆☆ Found in Text Mining only

GANC (glucosidase alpha, neutral C)

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