FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 117246
• Gene name: FtsJ RNA 2'-O-methyltransferase 3
• Gene symbol: FTSJ3
• Synonyms (NCBI Gene): EPCS3, SPB1
• Chromosome: 17
• Chromosome location: 17q23.3
• Summary: Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein

miRNA Show/Hide all (136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038257	hsa-miR-330-5p	CLASH	23622248
MIRT453252	hsa-miR-2392	PAR-CLIP	23592263
MIRT453251	hsa-miR-1265	PAR-CLIP	23592263
MIRT453250	hsa-miR-3158-3p	PAR-CLIP	23592263
MIRT453249	hsa-miR-892c-5p	PAR-CLIP	23592263
MIRT453248	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT453247	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT453245	hsa-miR-4721	PAR-CLIP	23592263
MIRT453246	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT453244	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453243	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453242	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453241	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453240	hsa-miR-27a-5p	PAR-CLIP	23592263
MIRT453239	hsa-miR-3175	PAR-CLIP	23592263
MIRT453238	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT453237	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT453236	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT453235	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT453234	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT453233	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT453232	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT453231	hsa-miR-4651	PAR-CLIP	23592263
MIRT453230	hsa-miR-608	PAR-CLIP	23592263
MIRT453229	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT453228	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT453227	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT453226	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT453225	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT453224	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT453223	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT453222	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT453221	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT453252	hsa-miR-2392	PAR-CLIP	23592263
MIRT453251	hsa-miR-1265	PAR-CLIP	23592263
MIRT453250	hsa-miR-3158-3p	PAR-CLIP	23592263
MIRT453249	hsa-miR-892c-5p	PAR-CLIP	23592263
MIRT453248	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT453247	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT453245	hsa-miR-4721	PAR-CLIP	23592263
MIRT453246	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT453244	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453243	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453242	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453241	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453240	hsa-miR-27a-5p	PAR-CLIP	23592263
MIRT453239	hsa-miR-3175	PAR-CLIP	23592263
MIRT453238	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT453237	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT453236	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT453235	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT453234	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT453233	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT453232	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT453231	hsa-miR-4651	PAR-CLIP	23592263
MIRT453230	hsa-miR-608	PAR-CLIP	23592263
MIRT453229	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT453228	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT453227	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT453226	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT453225	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT453224	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT453223	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT453222	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT453221	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT1005845	hsa-miR-214	CLIP-seq
MIRT1005846	hsa-miR-3619-5p	CLIP-seq
MIRT1005847	hsa-miR-4291	CLIP-seq
MIRT1005848	hsa-miR-4519	CLIP-seq
MIRT1005849	hsa-miR-505	CLIP-seq
MIRT1005850	hsa-miR-761	CLIP-seq
MIRT1005851	hsa-miR-922	CLIP-seq
MIRT1998065	hsa-miR-1208	CLIP-seq
MIRT1998066	hsa-miR-1295	CLIP-seq
MIRT1998067	hsa-miR-1324	CLIP-seq
MIRT1998068	hsa-miR-1909	CLIP-seq
MIRT1998069	hsa-miR-2116	CLIP-seq
MIRT1998070	hsa-miR-3136-3p	CLIP-seq
MIRT1998071	hsa-miR-3677-5p	CLIP-seq
MIRT1998072	hsa-miR-3934	CLIP-seq
MIRT1998073	hsa-miR-4468	CLIP-seq
MIRT1998074	hsa-miR-4489	CLIP-seq
MIRT1998075	hsa-miR-4677-5p	CLIP-seq
MIRT1998076	hsa-miR-4679	CLIP-seq
MIRT1998077	hsa-miR-663b	CLIP-seq
MIRT2535670	hsa-miR-1343	CLIP-seq
MIRT2535671	hsa-miR-151-3p	CLIP-seq
MIRT2535672	hsa-miR-1976	CLIP-seq
MIRT2535673	hsa-miR-204	CLIP-seq
MIRT2535674	hsa-miR-211	CLIP-seq
MIRT2535675	hsa-miR-2114	CLIP-seq
MIRT1005845	hsa-miR-214	CLIP-seq
MIRT2535676	hsa-miR-3064-3p	CLIP-seq
MIRT2535677	hsa-miR-3192	CLIP-seq
MIRT1005846	hsa-miR-3619-5p	CLIP-seq
MIRT2535678	hsa-miR-3659	CLIP-seq
MIRT2535679	hsa-miR-3667-3p	CLIP-seq
MIRT1998072	hsa-miR-3934	CLIP-seq
MIRT1005847	hsa-miR-4291	CLIP-seq
MIRT2535680	hsa-miR-4300	CLIP-seq
MIRT2535681	hsa-miR-4463	CLIP-seq
MIRT2535682	hsa-miR-4499	CLIP-seq
MIRT2535683	hsa-miR-4513	CLIP-seq
MIRT1005848	hsa-miR-4519	CLIP-seq
MIRT2535684	hsa-miR-4658	CLIP-seq
MIRT2535685	hsa-miR-4691-5p	CLIP-seq
MIRT2535686	hsa-miR-4755-5p	CLIP-seq
MIRT2535687	hsa-miR-496	CLIP-seq
MIRT1005849	hsa-miR-505	CLIP-seq
MIRT2535688	hsa-miR-554	CLIP-seq
MIRT2535689	hsa-miR-574-5p	CLIP-seq
MIRT2535690	hsa-miR-623	CLIP-seq
MIRT1005850	hsa-miR-761	CLIP-seq
MIRT2535691	hsa-miR-885-3p	CLIP-seq
MIRT2535692	hsa-miR-920	CLIP-seq
MIRT1005851	hsa-miR-922	CLIP-seq
MIRT2535670	hsa-miR-1343	CLIP-seq
MIRT2535671	hsa-miR-151-3p	CLIP-seq
MIRT2535672	hsa-miR-1976	CLIP-seq
MIRT2535673	hsa-miR-204	CLIP-seq
MIRT2535674	hsa-miR-211	CLIP-seq
MIRT2535675	hsa-miR-2114	CLIP-seq
MIRT2535676	hsa-miR-3064-3p	CLIP-seq
MIRT2535677	hsa-miR-3192	CLIP-seq
MIRT2535679	hsa-miR-3667-3p	CLIP-seq
MIRT1998072	hsa-miR-3934	CLIP-seq
MIRT2535680	hsa-miR-4300	CLIP-seq
MIRT2535681	hsa-miR-4463	CLIP-seq
MIRT2535682	hsa-miR-4499	CLIP-seq
MIRT2535683	hsa-miR-4513	CLIP-seq
MIRT2535685	hsa-miR-4691-5p	CLIP-seq
MIRT2535686	hsa-miR-4755-5p	CLIP-seq
MIRT2535687	hsa-miR-496	CLIP-seq
MIRT2535688	hsa-miR-554	CLIP-seq
MIRT2535690	hsa-miR-623	CLIP-seq
MIRT2535692	hsa-miR-920	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0001510	Process	RNA methylation	IDA	30626973
GO:0001510	Process	RNA methylation	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	21903422, 28514442, 30021884, 32296183, 32707033, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008649	Function	RRNA methyltransferase activity	IEA
GO:0008650	Function	RRNA (uridine-2'-O-)-methyltransferase activity	IBA
GO:0016435	Function	RRNA (guanine) methyltransferase activity	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0030688	Component	Preribosome, small subunit precursor	IEA
GO:0031167	Process	RRNA methylation	IBA
GO:0031167	Process	RRNA methylation	IEA
GO:0032259	Process	Methylation	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0062105	Function	RNA 2'-O-methyltransferase activity	IDA	30626973
GO:0062105	Function	RNA 2'-O-methyltransferase activity	IEA

Other IDs

• MIM: 618411
• HGNC: 17136
• e!Ensembl: ENSG00000108592

Protein

• UniProt ID: Q8IY81
• Protein name: pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)
• Protein function: RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. ; (Microbial infection) In case of infection b
• PDB: 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8IR1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01728	FtsJ	24 → 200	FtsJ-like methyltransferase	Family
  PF07780	Spb1_C	601 → 840	Spb1 C-terminal domain	Domain
  PF11861	DUF3381	231 → 400	Domain of unknown function (DUF3381)	Family

• Sequence:

  MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQ
  VAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAP
  NVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQA
  TKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEG
  YAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVL
  GRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEE
  EEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGM
  FSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAG
  VRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIED
  DADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSG
  TEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKH
  RILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVG
  KKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVA
  QLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQ
  KKKHKRK

• Sequence length: 847

Pathways

Reactome Pathway:

Major pathway of rRNA processing in the nucleolus and cytosol

Related Genes

No strongly related genes found yet for FTSJ3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FTSJ3.