Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 91010
Gene name Formin like 3
Gene symbol FMNL3
Synonyms (NCBI Gene)
FHOD3FRL2WBP-3WBP3
Chromosome 12
Chromosome location 12q13.12
Summary The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
497 Show/Hide all (497)
miRTarBase ID miRNA Experiments Reference
MIRT020759 hsa-miR-155-5p Proteomics 18668040
MIRT023798 hsa-miR-1-3p Proteomics 18668040
MIRT047179 hsa-miR-182-5p CLASH 23622248
MIRT046050 hsa-miR-125b-5p CLASH 23622248
MIRT723225 hsa-miR-6838-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27 Show/Hide all (27)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IDA 21834987
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616288 23698 ENSG00000161791
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IVF7
Protein name Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)
Protein function Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganizati
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02181 FH2 561 → 926 Formin Homology 2 Domain Family
PF06367 Drf_FH3 281 → 478 Diaphanous FH3 Domain Family
PF06371 Drf_GBD 26 → 149 Diaphanous GTPase-binding Domain Family
PF06371 Drf_GBD 208 → 278 Diaphanous GTPase-binding Domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in endothelial cells. {ECO:0000269|PubMed:22275430}.
Sequence
Sequence length 1028
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Cytoskeleton in muscle cells RHO GTPases Activate Formins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Cervical cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (34)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 36124068 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomegaly Cardiomegaly Pubtator 30442288 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy BEFREE 29686099, 30442288
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Dilated cardiomyopathy Pubtator 28296976 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Hypertrophic Hypertrophic cardiomyopathy Pubtator 23255317, 30442288, 33586461, 38051749, 39971408 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy, Familial Idiopathic Cardiomyopathy BEFREE 24088304
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular disease Pubtator 33586461 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Chronic Periodontitis Periodontitis Pubtator 24347629 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 25758200, 30228782
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 30228782 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only